Shape/properties collaborative intelligent manufacturing of artificial bone scaffold: structural design and additive manufacturing process DOI
Pei Feng, Lingxi Liu, Feng Yang

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 17(1), P. 012005 - 012005

Published: Nov. 8, 2024

Abstract Artificial bone graft stands out for avoiding limited source of autograft as well susceptibility to infection allograft, which makes it a current research hotspot in the field defect repair. However, traditional design and manufacturing method cannot fabricate scaffold that mimics complicated bone-like shape with interconnected porous structure multiple properties akin human natural bone. Additive manufacturing, can achieve implant’s tailored external contour controllable fabrication internal microporous structure, is able form almost any designed via layer-by-layer process. As additive promising building artificial scaffold, only combining excellent structural appropriate process produce ideal biological mechanical properties. In this article, we sum up analyze state art methods realize shape/properties collaborative intelligent manufacturing. Scaffold be mainly classified into based on unit cells whole while basic 3D bioprinting are recommended suitable fabrication. The challenges future perspectives manufactured also discussed.

Language: Английский

Multimaterial 3D and 4D Bioprinting of Heterogenous Constructs for Tissue Engineering DOI
Annan Chen, Wanying Wang, Zhengyi Mao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(34)

Published: Sept. 22, 2023

Additive manufacturing (AM), which is based on the principle of layer-by-layer shaping and stacking discrete materials, has shown significant benefits in fabrication complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components functions. Consequently, replication biomimetic using conventional AM processes a single material challenging. Multimaterial 3D 4D bioprinting (with time as fourth dimension) emerged promising solution constructing multifunctional that can mimic host microenvironment better than single-material alternatives. Notably, 4D-printed multimaterial architectures provide time-dependent programmable dynamic promote cell activity regeneration response to external stimuli. This paper first presents typical design strategies TE applications. Subsequently, latest are discussed, along their advantages challenges. In particular, potential smart highlighted. Furthermore, this review provides insights into how facilitate realization next-generation

Language: Английский

Citations

71
3D printed TPMS structural PLA/GO scaffold: Process parameter optimization, porous structure, mechanical and biological properties DOI
Wang Guo,

Yanjuan Yang,

Chao Liu

et al.

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2023, Volume and Issue: 142, P. 105848 - 105848

Published: April 18, 2023

Language: Английский

Citations

68
Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration DOI

Xun Yuan,

Wei Zhu, Zhongyuan Yang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: June 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Language: Английский

Citations

66
Role of heterogenous microstructure and deformation behavior in achieving superior strength-ductility synergy in zinc fabricated via laser powder bed fusion DOI Creative Commons

Zhi Dong,

Changjun Han, Yanzhe Zhao

et al.

International Journal of Extreme Manufacturing, Journal Year: 2024, Volume and Issue: 6(4), P. 045003 - 045003

Published: March 29, 2024

Abstract Zinc (Zn) is considered a promising biodegradable metal for implant applications due to its appropriate degradability and favorable osteogenesis properties. In this work, laser powder bed fusion (LPBF) additive manufacturing was employed fabricate pure Zn with heterogeneous microstructure exceptional strength-ductility synergy. An optimized processing window of LPBF established printing samples relative densities greater than 99% using power range 80 ∼ 90 W scanning speed 900 mm s −1 . The sample printed at exhibited hierarchical consisting millimeter-scale molten pool boundaries, micrometer-scale bimodal grains, nanometer-scale pre-existing dislocations, rapid cooling rates significant thermal gradients formed in the pools. highest ductility ∼12.1% among all reported LPBF-printed date appreciable ultimate tensile strength (∼128.7 MPa). Such superior synergy can be attributed presence multiple deformation mechanisms that are primarily governed by deformation-induced hardening resulting from alternative arrangement grains dislocations. Additionally, continuous strain facilitated through interactions between twins, dislocations as accumulated, further contributing These findings provide valuable insights into behavior underlying mechanical properties alloys applications.

Language: Английский

Citations

59
Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection DOI Creative Commons
Cijun Shuai,

Xiaoxin Shi,

Feng Yang

et al.

International Journal of Extreme Manufacturing, Journal Year: 2023, Volume and Issue: 6(1), P. 015101 - 015101

Published: Oct. 10, 2023

Highlights High-energy ball milling was proposed to construct oxygen vacancy defects. Scaffold with individualized shape and porous structure fabricated by selective laser sintering. Antibacterial material used adsorb H 2 O the site of bacterial infection. The accumulated could amplify Fenton reaction efficiency induce more ·OH. scaffold possessed matched mechanical properties good biocompatibility.

Language: Английский

Citations

55
Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity DOI
Cijun Shuai,

Xiaoxin Shi,

Kai Wang

et al.

Bio-Design and Manufacturing, Journal Year: 2024, Volume and Issue: 7(2), P. 105 - 120

Published: Feb. 27, 2024

Language: Английский

Citations

47
Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids DOI Creative Commons
Xiangyu Zhao, Na Li, Ziqi Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 21, 2024

Bone defects pose significant challenges in healthcare, with over 2 million bone repair surgeries performed globally each year. As a burgeoning force the field of tissue engineering, 3D printing offers novel solutions to traditional transplantation procedures. However, current 3D-printed scaffolds still face three critical material selection, methods, cellular self-organization and co-culture, significantly impeding their clinical application. In this comprehensive review, we delve into performance criteria that ideal should possess, particular focus on core faced by technology during translation. We summarize latest advancements non-traditional materials advanced techniques, emphasizing importance integrating organ-like technologies bioprinting. This combined approach enables more precise simulation natural structure function. Our aim writing review is propose effective strategies address these promote translation for defect treatment.

Language: Английский

Citations

23
Gradient matters via filament diameter-adjustable 3D printing DOI Creative Commons
Huawei Qu, Chongjian Gao, Kaizheng Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 4, 2024

Abstract Gradient matters with hierarchical structures endow the natural world excellent integrity and diversity. Currently, direct ink writing 3D printing is attracting tremendous interest, has been used to explore fabrication of 1D 2D by adjusting diameter, spacing, angle between filaments. However, it difficult generate complex gradient owing inherent limitations existing methods in terms available dimension, resolution, shape fidelity. Here, we report a filament diameter-adjustable strategy that enables conventional extrusion printers produce 1D, 2D, tunable heterogeneous continuously varying volume deposited on trajectory. In detail, develop diameter-programmable filaments customizing velocity height. To achieve high fidelity, specially add supporting layers at needed locations. Finally, showcase multi-disciplinary applications our creating horizontal, radial, axial structures, letter-embedded metastructures, tissue-mimicking scaffolds, flexible electronics, time-driven devices. By showing potential this strategy, anticipate could be easily extended variety filament-based additive manufacturing technologies facilitate development functionally graded structures.

Language: Английский

Citations

22
Chitosan microporous foam filled 3D printed polylactic acid-pearl macroporous scaffold: Dual-scale porous structure, biological and mechanical properties DOI
Wang Guo,

Ziying Peng,

Ning Deng

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140508 - 140508

Published: Jan. 1, 2025

Language: Английский

Citations

5
Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications DOI Open Access
Yong Pan, Han Zhao, Wenyong Huang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.

Language: Английский

Citations

3