Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Electrospinning
is
a
significant
manufacturing
strategy
to
create
micro/nanofiber
platforms
that
can
be
considered
biomedical
scaffold
for
tissue
engineering
repair
and
regeneration.
In
recent
years
researchers
have
continuously
broadened
the
equipment
design
materials
development
of
electrospinning
nanofiber
(ENPs),
which
evolved
from
single‐needle
multi‐needle
creating
3D
ENPs,
diversify
their
application
including
drugs/cell/growth
factors
release,
anti‐bacterial
anti‐inflammatory,
hemostasis,
wound
healing,
Herein,
multifunctional
ENPs
with
bioactive
polymer
fabricated
via
in
terms
novel
material
design,
construction
various
structures,
requirements
different
regeneration
are
reviewed.
Furthermore,
this
review
delves
into
advancements
facilitated
by
highlighting
effectiveness
versatility
across
types
such
as
bone,
cartilage,
tendons,
cardiac
tissue,
nerves.
The
discussion
comprehensively
addresses
ongoing
challenges
selection,
biodegradation
mechanisms,
bioactivation
strategies,
techniques
specific
applications.
Moreover,
outlines
potential
future
research
avenues
aimed
at
enhancing
ENPs‐based
approaches
engineering.
This
in‐depth
analysis
aims
provide
nuanced
insights
technical
recommendations
propel
field
forward
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(34)
Published: Sept. 22, 2023
Additive
manufacturing
(AM),
which
is
based
on
the
principle
of
layer-by-layer
shaping
and
stacking
discrete
materials,
has
shown
significant
benefits
in
fabrication
complicated
implants
for
tissue
engineering
(TE).
However,
many
native
tissues
exhibit
anisotropic
heterogenous
constructs
with
diverse
components
functions.
Consequently,
replication
biomimetic
using
conventional
AM
processes
a
single
material
challenging.
Multimaterial
3D
4D
bioprinting
(with
time
as
fourth
dimension)
emerged
promising
solution
constructing
multifunctional
that
can
mimic
host
microenvironment
better
than
single-material
alternatives.
Notably,
4D-printed
multimaterial
architectures
provide
time-dependent
programmable
dynamic
promote
cell
activity
regeneration
response
to
external
stimuli.
This
paper
first
presents
typical
design
strategies
TE
applications.
Subsequently,
latest
are
discussed,
along
their
advantages
challenges.
In
particular,
potential
smart
highlighted.
Furthermore,
this
review
provides
insights
into
how
facilitate
realization
next-generation
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2023,
Volume and Issue:
142, P. 105848 - 105848
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(34)
Published: June 11, 2024
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
severe
trauma,
surgical
resection,
degenerative
disease,
congenital
malformation
pose
significant
clinical
challenges.
Bone
tissue
engineering
(BTE)
holds
immense
potential
in
treating
these
defects,
without
incurring
prevalent
complications
associated
with
conventional
autologous
or
allogeneic
grafts.
3D
printing
technology
enables
control
over
architectural
structures
at
multiple
length
scales
has
been
extensively
employed
to
process
biomimetic
scaffolds
for
BTE.
In
contrast
inert
grafts,
next-generation
smart
possess
a
remarkable
ability
mimic
the
dynamic
nature
native
extracellular
matrix
(ECM),
thereby
facilitating
regeneration.
Additionally,
they
can
generate
tailored
controllable
therapeutic
effects,
such
as
antibacterial
antitumor
properties,
response
exogenous
and/or
endogenous
stimuli.
This
review
provides
comprehensive
assessment
progress
3D-printed
BTE
applications.
It
begins
an
introduction
physiology,
followed
by
overview
technologies
utilized
scaffolds.
Notable
advances
various
stimuli-responsive
strategies,
efficacy,
applications
are
discussed.
Finally,
highlights
existing
challenges
development
implementation
scaffolds,
well
emerging
this
field.
International Journal of Extreme Manufacturing,
Journal Year:
2024,
Volume and Issue:
6(4), P. 045003 - 045003
Published: March 29, 2024
Abstract
Zinc
(Zn)
is
considered
a
promising
biodegradable
metal
for
implant
applications
due
to
its
appropriate
degradability
and
favorable
osteogenesis
properties.
In
this
work,
laser
powder
bed
fusion
(LPBF)
additive
manufacturing
was
employed
fabricate
pure
Zn
with
heterogeneous
microstructure
exceptional
strength-ductility
synergy.
An
optimized
processing
window
of
LPBF
established
printing
samples
relative
densities
greater
than
99%
using
power
range
80
∼
90
W
scanning
speed
900
mm
s
−1
.
The
sample
printed
at
exhibited
hierarchical
consisting
millimeter-scale
molten
pool
boundaries,
micrometer-scale
bimodal
grains,
nanometer-scale
pre-existing
dislocations,
rapid
cooling
rates
significant
thermal
gradients
formed
in
the
pools.
highest
ductility
∼12.1%
among
all
reported
LPBF-printed
date
appreciable
ultimate
tensile
strength
(∼128.7
MPa).
Such
superior
synergy
can
be
attributed
presence
multiple
deformation
mechanisms
that
are
primarily
governed
by
deformation-induced
hardening
resulting
from
alternative
arrangement
grains
dislocations.
Additionally,
continuous
strain
facilitated
through
interactions
between
twins,
dislocations
as
accumulated,
further
contributing
These
findings
provide
valuable
insights
into
behavior
underlying
mechanical
properties
alloys
applications.
International Journal of Extreme Manufacturing,
Journal Year:
2023,
Volume and Issue:
6(1), P. 015101 - 015101
Published: Oct. 10, 2023
Highlights
High-energy
ball
milling
was
proposed
to
construct
oxygen
vacancy
defects.
Scaffold
with
individualized
shape
and
porous
structure
fabricated
by
selective
laser
sintering.
Antibacterial
material
used
adsorb
H
2
O
the
site
of
bacterial
infection.
The
accumulated
could
amplify
Fenton
reaction
efficiency
induce
more
·OH.
scaffold
possessed
matched
mechanical
properties
good
biocompatibility.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 21, 2024
Bone
defects
pose
significant
challenges
in
healthcare,
with
over
2
million
bone
repair
surgeries
performed
globally
each
year.
As
a
burgeoning
force
the
field
of
tissue
engineering,
3D
printing
offers
novel
solutions
to
traditional
transplantation
procedures.
However,
current
3D-printed
scaffolds
still
face
three
critical
material
selection,
methods,
cellular
self-organization
and
co-culture,
significantly
impeding
their
clinical
application.
In
this
comprehensive
review,
we
delve
into
performance
criteria
that
ideal
should
possess,
particular
focus
on
core
faced
by
technology
during
translation.
We
summarize
latest
advancements
non-traditional
materials
advanced
techniques,
emphasizing
importance
integrating
organ-like
technologies
bioprinting.
This
combined
approach
enables
more
precise
simulation
natural
structure
function.
Our
aim
writing
review
is
propose
effective
strategies
address
these
promote
translation
for
defect
treatment.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: April 4, 2024
Abstract
Gradient
matters
with
hierarchical
structures
endow
the
natural
world
excellent
integrity
and
diversity.
Currently,
direct
ink
writing
3D
printing
is
attracting
tremendous
interest,
has
been
used
to
explore
fabrication
of
1D
2D
by
adjusting
diameter,
spacing,
angle
between
filaments.
However,
it
difficult
generate
complex
gradient
owing
inherent
limitations
existing
methods
in
terms
available
dimension,
resolution,
shape
fidelity.
Here,
we
report
a
filament
diameter-adjustable
strategy
that
enables
conventional
extrusion
printers
produce
1D,
2D,
tunable
heterogeneous
continuously
varying
volume
deposited
on
trajectory.
In
detail,
develop
diameter-programmable
filaments
customizing
velocity
height.
To
achieve
high
fidelity,
specially
add
supporting
layers
at
needed
locations.
Finally,
showcase
multi-disciplinary
applications
our
creating
horizontal,
radial,
axial
structures,
letter-embedded
metastructures,
tissue-mimicking
scaffolds,
flexible
electronics,
time-driven
devices.
By
showing
potential
this
strategy,
anticipate
could
be
easily
extended
variety
filament-based
additive
manufacturing
technologies
facilitate
development
functionally
graded
structures.
