Metal-based immunogenic cell death inducers for cancer immunotherapy DOI Creative Commons
Jun Zou, Meng Rui Chang, Nikita A. Kuznetsov

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Immunogenic cell death (ICD) has attracted enormous attention over the past decade due to its unique characteristics in cancer and role activating innate adaptive immune responses against tumours. Many efforts have been dedicated screening, identifying discovering ICD inducers, resulting validation of several based on metal complexes. In this review, we provide a comprehensive summary current metal-based their molecular mechanisms for triggering initiation subsequent protective antitumour responses, along with considerations validating both vitro vivo. We also aim offer insights into future development complexes enhanced ICD-inducing properties applications potentiating immunity.

Language: Английский

Simultaneous Activation of Pyroptosis and cGAS‐STING Pathway with Epigenetic/ Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy DOI Open Access

Feixiang Ding,

Junyan Liu, Kelong Ai

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(7)

Published: Oct. 5, 2023

Promoting innate immunity through pyroptosis induction or the cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) pathway activation has emerged as a potent approach to counteract immunosuppressive tumor microenvironment and elicit systemic antitumor immunity. However, current inducers STING agonists often suffer from limitations including instability, unpredictable side effects, inadequate intracellular expression gasdermin STING. Here, tumor-specific nanotheranostic platform that combines photodynamic therapy (PDT) with epigenetic simultaneously activate cGAS-STING in light-controlled manner is constructed. This involves development oxidation-sensitive nanoparticles (NP1) loaded photosensitizer TBE, along decitabine nanomicelles (NP2). NP2 enables restoration E (GSDME) expression, while NP1-mediated PDT facilitates release DNA fragments damaged mitochondria potentiate pathway, promotes caspase-3 cleave upregulated GSDME into pore-forming GSDME-N terminal. Subsequently, released inflammatory cytokines facilitate maturation antigen-presentation cells, triggering T cell-mediated Overall, this study presents an elaborate strategy for simultaneous photoactivation enabling targeted photoimmunotherapy immunotolerant tumors. innovative holds significant promise overcoming associated existing therapeutic modalities represents valuable avenue future clinical applications.

Language: Английский

Citations

48
Near-infrared boron–dipyrrin (BODIPY) nanomaterials: Molecular design and anti-tumor therapeutics DOI
Yaojun Li,

Minling Jiang,

Miaomiao Yan

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215718 - 215718

Published: Feb. 18, 2024

Language: Английский

Citations

31
Encapsulation of Ru(II) Polypyridine Complexes for Tumor-Targeted Anticancer Therapy DOI Creative Commons
Johannes Karges

BME Frontiers, Journal Year: 2023, Volume and Issue: 4

Published: Jan. 1, 2023

Ru(II) polypyridine complexes have attracted much attention as anticancer agents because of their unique photophysical, photochemical, and biological properties. Despite promising therapeutic profile, the vast majority compounds are associated with poor water solubility cancer selectivity. Among different strategies employed to overcome these pharmacological limitations, many research efforts been devoted physical or covalent encapsulation into nanoparticles. This article highlights recent developments in design, preparation, physicochemical properties complex-loaded nanoparticles for potential application therapy.

Language: Английский

Citations

28
Platinum-based drugs in cancer treatment: Expanding horizons and overcoming resistance DOI
Mona Shahlaei,

Shaahin Mohammadzadeh Asl,

Atefe Derakhshani

et al.

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1301, P. 137366 - 137366

Published: Dec. 19, 2023

Language: Английский

Citations

25
Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy DOI Creative Commons

Renming Fan,

Ruizhuo Lin,

Shuo Zhang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(4), P. 1742 - 1758

Published: Dec. 16, 2023

Mitochondrial membrane remodeling can trigger the release of mitochondrial DNA (mtDNA), leading to activation cellular oxidative stress and immune responses. While role in promoting inflammation hepatocytes is well-established, its effects on tumors have remained unclear. In this study, we designed a novel Pt(IV) complex, OAP2, which composed oxaliplatin (Oxa) acetaminophen (APAP), enhance anti-tumor amplify response. Our findings demonstrate that OAP2 induces nuclear damage, resulting production DNA. Additionally, downregulates expression Sam50, promote mtDNA secretion, double-stranded accumulation ultimately synergistically activating intracellular cGAS-STING pathway. The induced by overcomes limitations Oxa STING pathway simultaneously promotes gasdermin-D-mediated cell pyroptosis. also dendritic maturation enhances quantity efficacy cytotoxic T cells, thereby inhibiting cancer proliferation metastasis. Briefly, our study introduces first small-molecule inhibitor regulates for active immunotherapy research, may provide creative idea targeting organelle therapy.

Language: Английский

Citations

24
A NIR‐Light‐Activated and Lysosomal‐Targeted Pt(II) Metallacycle for Highly Potent Evoking of Immunogenic Cell Death that Potentiates Cancer Immunotherapy of Deep‐Seated Tumors DOI

Chonglu Li,

Le Tu, Yuling Xu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(37)

Published: May 22, 2024

Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8

Language: Английский

Citations

14
Rhenium(I) coordinated carbon nitride as type II immunogenic cell death inducers for enhancing photoimmunotherapy against triple-negative breast cancer DOI

Fangmian Wei,

Jinzhe Liang,

Zhushuang Tan

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 150154 - 150154

Published: March 2, 2024

Language: Английский

Citations

12
Self‐Carrier Nanoparticles for Delivery of Paclitaxel and IDO Inhibitor to Boost Antitumor Chemo‐Immunotherapy DOI
Zixuan Li,

Qing Pei,

Min Zhao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)

Published: March 21, 2024

Abstract The combination of chemotherapy and immunotherapy holds great potential in clinical treatment advanced cancers. Whereas, the therapeutic outcome chemotherapeutic immune regulator is suboptimal due to their poor tumor availability severe off‐target toxicity. Herein, self‐carrier nanoparticles (PSMT NPs) integrating a paclitaxel (PTX) prodrug indoleamine 2,3‐dioxygenase 1 (IDO) inhibitor (1‐methyl‐tryptophan, 1MT) for tumor‐specific chemo‐immunotherapy constructed. After internalization by cancer cells, PSMT NPs can respond endogenous redox stimulus, release PTX 1MT. released not only promote cell apoptosis via intervention mitosis but also initiate immunogenic death facilitate recruitment activation tumor‐infiltrating cytotoxic T lymphocytes. concomitant 1MT inhibit IDO activity exhaust regulatory thereby synergistically activating exhibit potentiated antitumor output toward triple‐negative breast negligible systemic This facile versatile nanoplatform provides promising strategy cooperatively activate immunity chemo‐immunotherapy.

Language: Английский

Citations

12
Nanoparticles destabilizing the cell membranes triggered by NIR light for cancer imaging and photo-immunotherapy DOI Creative Commons
Dongsheng Tang,

Minhui Cui,

Bin Wang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 17, 2024

Abstract Cationic polymers have great potential for cancer therapy due to their unique interactions with cells. However, clinical application remains limited by high toxicity. Here we show a cell membrane-targeting cationic polymer antineoplastic activity (P mt ) and second near-infrared (NIR-II) fluorescent biodegradable photosensitizer Bodipy units reactive oxygen species (ROS) responsive thioketal bonds ). Subsequently, these two can self-assemble into nanoparticles (denoted mt-NP which could further accumulate at the tumor destroy membranes through electrostatic interactions, resulting in membrane destabilization. Meanwhile, produces ROS induce damage membranes, proteins, DNAs kill cells concertedly, finally lysis death. This work highlights use of light spatially temporarily control photodynamic therapy, photo-immunotherapy, NIR-II fluorescence bio-imaging.

Language: Английский

Citations

12
A Bodipy‐Based Aggregation‐Induced Emission Nanoagent for Sonodynamic Antibacterial Studies DOI
Yanchao Xu, Dongsheng Tang, Lei‐Jiao Li

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: March 22, 2024

Abstract Sonodynamic therapy (SDT) has demonstrated significant potential in addressing multidrug‐resistant bacterial infections due to its noninvasive nature and independence from antibiotics light sources. However, the majority of current sonosensitizers exhibit aggregation‐caused quenching (ACQ), leading low reactive oxygen species (ROS) generation efficiency. Herein, a novel nonplanar structured sonodynamic (4,4‐difluoro‐4‐boron‐3a,4‐diaza‐indandiene) BODIPY derivative, BODN, with aggregation‐induced emission (AIE) properties, rapid substantial ROS by ultrasound is introduced. The BODN co‐assembled commercial amphiphilic polymer, mDSPE‐PEG 2000 , forming nanoparticles (BODN‐NP). Under conditions, BODN‐NP demonstrates potent antimicrobial activity improves inflammatory response promote healing wounds infected both Staphylococcus aureus methicillin‐resistant . This work expands use AIE materials provides new perspectives for innovative solutions against infections.

Language: Английский

Citations

9