Drug Development Research,
Journal Year:
2024,
Volume and Issue:
85(8)
Published: Dec. 1, 2024
ABSTRACT
The
development
of
anticancer
drugs
that
target
different
organelles
has
received
extensive
attention
due
to
the
characteristics
cancer
recurrence,
metastasis,
and
drug
resistance.
endoplasmic
reticulum
(ER)
is
an
important
structure
within
cell
primarily
responsible
for
protein
synthesis,
folding,
modification,
transport
plays
a
crucial
role
in
function
health.
ER
stress
activation
induces
apoptosis.
New
with
mechanisms
selectivity
can
be
designed
because
redox
activity,
composition
diversity,
metal
complexes
regulation.
Over
past
few
decades,
dozens
have
killed
cells
through
stress,
showing
powerful
tumor‐suppressive
effects.
This
review
summarizes
progress
research
on
metallic
induce
over
years,
which
expected
bring
more
breakthroughs
field
medicine
life
science.
Small Methods,
Journal Year:
2024,
Volume and Issue:
8(11)
Published: Sept. 25, 2024
Abstract
Despite
the
advent
of
various
medical
interventions
for
cancer
treatment,
disease
continues
to
pose
a
formidable
global
health
challenge,
necessitating
development
new
therapeutic
approaches
more
effective
treatment
outcomes.
Photodynamic
therapy
(PDT),
which
utilizes
light
activate
photosensitizer
produce
cytotoxic
reactive
oxygen
species
(ROS)
eradicating
cells,
has
emerged
as
promising
approach
due
its
high
spatiotemporal
precision
and
minimal
invasiveness.
However,
widespread
clinical
use
PDT
faces
several
challenges,
including
inefficient
production
ROS
in
hypoxic
tumor
microenvironment,
limited
penetration
depth
biological
tissues,
inadequate
accumulation
photosensitizers
at
site.
Over
past
decade,
there
been
increasing
interest
utilization
photofunctional
transition
metal
complexes
applications
their
intriguing
photophysical
photochemical
properties.
This
review
provides
an
overview
current
design
strategies
used
innovative
phototherapeutics,
aiming
address
limitations
associated
with
achieve
The
challenges
future
perspectives
on
translation
are
also
discussed.
Smart Molecules,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
Abstract
The
clinical
approval
of
platinum‐based
drugs
has
prompted
the
development
novel
metallo‐complexes
during
last
several
decades,
while
severe
problems,
especially
for
poor
water
solubility,
drug
resistance
and
toxicity
in
patients,
greatly
hindered
trials
curative
efficacy.
To
address
these
issues,
concept
metallo‐prodrugs
been
proposed
oncology.
Some
stimuli‐activable
provide
new
insights
designing
preparing
site‐specific
prodrugs
with
maximized
therapeutic
efficacy
negligible
unfavorable
by‐effects.
In
this
review,
recent
progress
past
20
years
overviewed,
where
endogenous
exogenous
stimuli
have
involved.
Typical
examples
smart
are
discussed
regarding
to
their
molecular
structure,
activation
mechanism,
promising
biomedical
applications.
end,
challenges
future
perspectives
discussed.
Inorganic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
In
this
work,
novel
zinc(
ii
)
phthalocyanine
nanoparticles
(ZnPcNPs)
have
been
developed
and
verified
to
be
a
promising
PTT/PDT
agent
with
high
photoconversion
efficiency
of
30.01%
under
660
nm
NIR-I
laser
exposure.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Immunogenic
cell
death
(ICD)
has
attracted
enormous
attention
over
the
past
decade
due
to
its
unique
characteristics
in
cancer
and
role
activating
innate
adaptive
immune
responses
against
tumours.
Many
efforts
have
been
dedicated
screening,
identifying
discovering
ICD
inducers,
resulting
validation
of
several
based
on
metal
complexes.
In
this
review,
we
provide
a
comprehensive
summary
current
metal-based
their
molecular
mechanisms
for
triggering
initiation
subsequent
protective
antitumour
responses,
along
with
considerations
validating
both
vitro
vivo.
We
also
aim
offer
insights
into
future
development
complexes
enhanced
ICD-inducing
properties
applications
potentiating
immunity.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
In
recent
years,
cancer
has
emerged
as
a
major
global
health
threat,
ranking
among
the
top
causes
of
mortality.
While
treatments
such
surgery,
immunotherapy,
radiation
therapy,
and
chemotherapy
remain
widely
used,
photodynamic
therapy
been
gaining
significant
interest.
Most
photosensitizing
agents
employed
in
clinical
settings
are
derived
from
tetrapyrrolic
frameworks,
including
porphyrins,
chlorins,
phthalocyanines.
Although
these
compounds
have
demonstrated
therapeutic
effectiveness,
they
suffer
critical
drawbacks,
limited
solubility
water
inadequate
(photo)stability.
To
address
issues,
herein,
formulation
previously
reported
promising
photosensitizer
tetrakis(4-carboxyphenyl)
porphyrin
into
carbon
dots
is
reported.
The
were
found
with
enhanced
aqueous
solubility,
high
(photo)stability,
greater
singlet
oxygen
quantum
yield
overcoming
limitations
molecular
photosensitizer.
being
nontoxic
dark,
induced
phototherapeutic
effect
breast
cells
multicellular
tumor
spheroids.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
15(2), P. 852 - 875
Published: Nov. 23, 2024
Cancer
immunotherapy
is
currently
a
very
promising
therapeutic
strategy
for
treating
tumors.
However,
its
effectiveness
restricted
by
insufficient
antigenicity
and
an
immunosuppressive
tumor
microenvironment
(ITME).
Pyroptosis,
unique
form
of
programmed
cell
death
(PCD),
causes
cells
to
swell
rupture,
releasing
pro-inflammatory
factors
that
can
enhance
immunogenicity
remodel
the
ITME.
Nanomaterials,
with
their
distinct
advantages
different
techniques,
are
increasingly
popular,
nanomaterial-based
delivery
systems
demonstrate
significant
potential
potentiate,
enable,
augment
pyroptosis.
This
review
summarizes
discusses
emerging
field
nanomaterials-induced
pyroptosis,
focusing
on
mechanisms
pyroptosis
pathways
strategies
activate
or
specific
Additionally,
we
provide
perspectives
development
this
field,
aiming
accelerate
further
clinical
transition.
