Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers DOI Creative Commons
Rosana V. Pinto, Moisés L. Pinto, Christian Serre

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Gas therapy using gasotransmitters is of exponential interest due to the growing recognition gas signaling molecules that can be involved in multiple therapeutic actions. Finding suitable methods for delivering these crucial, and porous materials, notably metal-organic frameworks (MOFs), have shown exceptional potential as carriers, enabling safe controlled local delivery. The challenges translate MOF therapies clinical use require not only validate mechanisms action pathways released but also get a deep understanding into rational design, it requires combination features maximize outcomes. In this perspective, we outline key criteria designing MOFs delivery applications highlight expanding range opportunities materials may offer. Readers insights design develop gasotransmitter with realistic clinic interest.

Language: Английский

Metal–organic frameworks for biological applications DOI
Isabel Abánades Lázaro, Xu Chen,

Mengli Ding

et al.

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: June 27, 2024

Language: Английский

Citations

48
Reproducibility in research into metal-organic frameworks in nanomedicine DOI Creative Commons
Ross S. Forgan

Communications Materials, Journal Year: 2024, Volume and Issue: 5(1)

Published: April 5, 2024

Abstract Metal-organic frameworks (MOFs) are currently widely investigated for a number of potential biomedicinal applications, with particular focus on nanoscale drug delivery. Nanomedicine in general comes specific challenges to ensure reproducibility results, including batch-to-batch variations ostensibly the same nanomaterial, differences synthetic and analytical practices, intrinsic issues vitro culturing assaying, lack availability raw data comparative analysis. This perspective provides an overview context MOFs nanomedicine, covering their preparation The commonly studied UiO-66 is used as exemplar highlight variability characterisation well publication data. Some common roadblocks highlighted, alongside suggestions resources best practice.

Language: Английский

Citations

13
Microgels-Encapsulated Magnesium/Emodin-based metal organic framework nanorods for diabetic bone regeneration DOI Creative Commons
Di Wang, Yajie Wang,

Daiying Song

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150585 - 150585

Published: March 20, 2024

Diabetic bone defect repair is one of the major challenges in clinic, because pathological microenvironments such as hyperglycemia, oxidative stress, and inflammation exist area diabetes mellitus. Although current tissue-engineered has achieved favorable regeneration functional reconstruction, it still unsatisfactory for diabetic only by correcting a single factor. In this study, we develop multifunctional nano-releasing system GelMA/HAMA microgels-encapsulated Mg2+/Emodin (MgEm) nanorods based on MOF design principle (denoted MEGH) reversing microenvironment. For slow-release MEGH microgels, Emodin exert hypoglycemic, antioxidant, anti-inflammatory function, while Mg2+ ions could promote angiogenesis regeneration. Subsequently, combine decalcified matrix with regenerative units BMSCs-loaded microgels (BMSCs@MEGH-D) construction bone. Finally, pre-constructed BMSCs@MEGH-D scaffolds successfully vascularized rabbit skull models due to effective correction The underlying mechanism indicates synergetic efficacy regulate glucose, inflammation, oxygen-related bioprocesses, well osteogenesis-related pathways. Our findings provide promising treatment microenvironment accelerate repair.

Language: Английский

Citations

10
Surface functionalization of metal–organic framework nanoparticle for overcoming biological barrier in cancer therapy DOI Creative Commons
Jun Yong Oh,

Youjung Sim,

Gyeongseok Yang

et al.

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(11), P. 3119 - 3135

Published: Jan. 1, 2024

Surface modification of MOF particle for overcoming biological barriers.

Language: Английский

Citations

9
Applications of Material Institute Lavoisier (MIL) based materials as nano drug delivery carriers in biomedicine DOI
Xuanxuan Wang, Nan Gao,

Jiuhong Zhao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 216040 - 216040

Published: June 20, 2024

Language: Английский

Citations

9
Biomedical Applications of Metal–Organic Frameworks Revisited DOI Creative Commons

Pelin Sezgin,

Ezgi Gulcay-Ozcan, Marija Vučkovski

et al.

Industrial & Engineering Chemistry Research, Journal Year: 2025, Volume and Issue: 64(4), P. 1907 - 1932

Published: Jan. 14, 2025

Metal–organic frameworks (MOFs) have been shown to be great alternatives traditional porous materials in various chemical applications, and they very widely studied for biomedical applications the past decade specifically drug storage. After our review published 2011 [Keskin Kızılel, Ind. Eng. Chem. Res. 2011, 50 (4), 1799–1812, 10.1021/ie101312k], we witnessed a fast growth not only number variety of MOFs but also their usage across broad spectrum fields. With recent integration molecular modeling data science approaches experimental studies, significantly accelerated positioning them as pivotal components regenerative medicine, medical imaging, diagnostics. In this review, visited diverse considering computational efforts on storage delivery, bioimaging, biosensing. We focused underlying mechanisms governing interactions between biological systems discussed both opportunities challenges field highlight potential advanced therapeutics cancer neurological diseases.

Language: Английский

Citations

1
Metal-organic frameworks in oral drug delivery DOI Creative Commons
Aun Raza, Wei Wu

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100951 - 100951

Published: Aug. 23, 2024

Metal-organic frameworks (MOFs) offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination metal ions and organic ligands. This review systematically examines structural properties principles MOFs, setting stage for application in delivery. It discusses various classes including those based on zirconium, iron, zinc, copper, titanium, aluminum, potassium, magnesium, assessing drug-loading capacities, biocompatibility, controlled release mechanisms. The effectiveness MOFs is illustrated case studies that highlight capabilities enhancing solubility, providing protection against harsh gastrointestinal environment, enabling precise release. addresses potential challenges, particularly toxicity concerns associated with calls further research into biocompatibility interactions biological systems. concludes by emphasizing revolutionizing delivery, highlighting critical need comprehensive harness full clinical applications.

Language: Английский

Citations

8
Research Progress of Metal–Organic Frameworks as Drug Delivery Systems DOI

Chenxin Liu,

Chaoying Tian,

Jialing Guo

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(33), P. 43156 - 43170

Published: Aug. 12, 2024

Metal-organic frameworks (MOFs) are composite crystalline materials created through the coordination of metal ions and organic ligands. MOFs have attracted extensive attention in biomedical field based on advantages internal porosity, customizable facile surface modification. This review examines utilization drug delivery systems, focusing research progress from aspects coloading intelligent responsive carriers, biological macromolecule stabilizers, self-driving micro/nanomotors, multifunctional living carriers. In addition, current challenges faces also discussed. The aims to provide a reference for further application as advanced systems.

Language: Английский

Citations

7
MOFs for next-generation cancer therapeutics through a biophysical approach—a review DOI Creative Commons

Leon Bernet Shano,

S. Karthikeyan, L. John Kennedy

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: June 13, 2024

Metal-organic frameworks (MOFs) have emerged as promising nanocarriers for cancer treatment due to their unique properties. Featuring high porosity, extensive surface area, chemical stability, and good biocompatibility, MOFs are ideal efficient drug delivery, targeted therapy, controlled release. They can be designed target specific cellular organelles disrupt metabolic processes in cells. Additionally, functionalization with enzymes mimics catalytic activity, enhancing photodynamic therapy overcoming apoptosis resistance The controllable regular structure of MOFs, along tumor microenvironment responsiveness, make them anticancer drugs. These carriers effectively deliver a wide range drugs improved bioavailability, release rate, delivery efficiency compared alternatives. In this article, we review both experimental computational studies focusing on the interaction between drug, explicating mechanisms stability physiological conditions. Notably, explore relationship MOF its ability damage cells, elucidating why excellent candidates bio-applicability. By understanding problem exploring potential solutions, provides insights into future directions harnessing full ultimately leading therapeutic outcomes treatment.

Language: Английский

Citations

6
Amyloid detection in neurodegenerative diseases using MOFs DOI

Ketan Maru,

Amarendra Singh, Ritambhara Jangir

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(19), P. 4553 - 4573

Published: Jan. 1, 2024

Neurodegenerative diseases (amyloid such as Alzheimer's and Parkinson's), stemming from protein misfolding aggregation, encompass a spectrum of disorders with severe systemic implications. Timely detection is pivotal in managing these owing to their significant impact on organ function high mortality rates. The diverse array amyloid disorders, spanning localized manifestations, underscores the complexity conditions highlights need for advanced methods. Traditional approaches have focused identifying biomarkers using imaging techniques (PET MRI) or invasive procedures. However, recent efforts use metal-organic frameworks (MOFs), versatile class materials known unique properties, revolutionizing disease detection. porosity, customizable structures, biocompatibility MOFs enable integration biomolecules, laying groundwork highly sensitive specific biosensors. These sensors been employed electrochemical photophysical that target species under neurodegenerative conditions. adaptability allows precise quantification proteins, offering potential advancements early diagnosis management. This review article delves into how contribute detecting by categorizing uses based different sensing methods, (EC), electrochemiluminescence (ECL), fluorescence, Förster resonance energy transfer (FRET), up-conversion luminescence (ULRET), photoelectrochemical (PEC) sensing. drawbacks MOF biosensors challenges encountered field are also briefly explored our perspective.

Language: Английский

Citations

5