Small,
Journal Year:
2024,
Volume and Issue:
20(34)
Published: April 21, 2024
Single-atom
enzymes
(SAzymes)
exhibit
great
potential
for
chemodynamic
therapy
(CDT);
while,
general
application
is
still
challenged
by
their
instability
and
unavoidable
side
effects
during
delivery.
Herein,
a
manganese-based
polyoxometalate
single-atom
enzyme
(Mn-POM
SAE)
first
introduced
into
tumor-specific
CDT,
which
exhibits
tumor
microenvironment
(TME)-activated
transition
of
nontoxicity-to-toxicity.
Different
from
traditional
POM
materials,
the
aggregates
low-toxic
Mn-POM
SAE
nanospheres
are
obtained
at
neutral
conditions,
facilitating
efficient
delivery
avoiding
toxicity
problems
in
normal
tissues.
Under
acid
TME
these
degraded
smaller
units
toxic
Mn(II)-PW
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(22), P. 15251 - 15263
Published: May 23, 2024
Glioblastoma
(GBM)
poses
a
significant
therapeutic
challenge
due
to
its
invasive
nature
and
limited
drug
penetration
through
the
blood–brain
barrier
(BBB).
In
response,
here
we
present
an
innovative
biomimetic
approach
involving
development
of
genetically
engineered
exosome
nanocatalysts
(Mn@Bi2Se3@RGE-Exos)
for
efficient
GBM
therapy
via
improving
BBB
enzyme-like
catalytic
activities.
Interestingly,
photothermally
activatable
multiple
reactivity
is
observed
in
such
nanosystem.
Upon
NIR-II
light
irradiation,
Mn@Bi2Se3@RGE-Exos
are
capable
converting
hydrogen
peroxide
into
hydroxyl
radicals,
oxygen,
superoxide
providing
peroxidase
(POD),
oxidase
(OXD),
catalase
(CAT)-like
nanocatalytic
cascade.
This
consequently
leads
strong
oxidative
stresses
damage
cells.
vitro,
vivo,
proteomic
analysis
further
reveal
potential
disruption
cellular
homeostasis,
enhancement
immunological
induction
cancer
cell
ferroptosis,
showcasing
great
promise
anticancer
efficacy
against
with
favorable
biosafety
profile.
Overall,
success
this
study
provides
feasible
strategy
future
design
clinical
stimuli-responsive
medicine,
especially
context
challenging
brain
cancers
like
GBM.
Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 15, 2025
Abstract
The
proliferation
of
wearable
biodevices
has
boosted
the
development
soft,
innovative,
and
multifunctional
materials
for
human
health
monitoring.
integration
sensors
with
intelligent
systems
is
an
overwhelming
tendency,
providing
powerful
tools
remote
monitoring
personal
management.
Among
many
candidates,
two-dimensional
(2D)
stand
out
due
to
several
exotic
mechanical,
electrical,
optical,
chemical
properties
that
can
be
efficiently
integrated
into
atomic-thin
films.
While
previous
reviews
on
2D
primarily
focus
conventional
configurations
like
graphene,
rapid
new
opened
up
novel
applications,
particularly
in
smart
interaction
functionalities.
This
review
aims
consolidate
recent
progress,
highlight
unique
advantages
materials,
guide
future
research
by
discussing
existing
challenges
opportunities
applying
biodevices.
We
begin
in-depth
analysis
advantages,
sensing
mechanisms,
potential
applications
biodevice
fabrication.
Following
this,
we
systematically
discuss
state-of-the-art
based
various
physiological
signals
within
body.
Special
attention
given
showcasing
multi-functionality
devices,
mainly
including
self-power
supply,
diagnosis/treatment,
human–machine
interaction.
Finally,
concludes
a
concise
summary
prospective
solutions
concerning
utilization
advanced
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
MXenzymes,
a
promising
class
of
catalytic
therapeutic
material,
offer
great
potential
for
tumor
treatment,
but
they
encounter
significant
obstacles
due
to
suboptimal
efficiency
and
kinetics
in
the
microenvironment
(TME).
Herein,
this
study
draws
inspiration
from
electronic
structure
transition
metal
vanadium,
proposing
leverage
TME
specific-features
induce
structural
transformations
sheet-like
vanadium
carbide
MXenzymes
(TVMz).
These
trigger
cascading
reactions
that
amplify
oxidative
stress,
thereby
significantly
enhancing
multimodal
therapy.
Specifically,
engineered
HTVMz,
coated
with
hyaluronic
acid,
exhibits
good
stability
generates
thermal
effect
under
NIR-II
laser
irradiation.
The
effect,
combined
characteristics,
facilities
transformation
into
ultra-small
oxide
nanozymes
(VOx).
enlarged
surface
area
VOx
substantially
enhances
ROS
regeneration
amplifies
which
promotes
lysosomal
permeability
induces
endoplasmic
reticulum
stress.
high-valent
interacts
intracellular
glutathione,
disrupting
redox
homeostasis
intensifying
stress
further.
amplifications
accelerate
apoptosis,
ferroptosis,
suppress
HSP90
expression.
Consequently,
heightened
sensitivity
HTVMz
synergistically
cell
death
via
pathways.
This
presents
an
innovative
strategy
therapy
by
manipulating
structures,
advancing
field
