Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy DOI Creative Commons

Huan He,

Qin Zhang, Yiming Zhang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 20, 2025

Rheumatoid arthritis (RA) is a common chronic autoimmune condition accompanied by lubrication dysfunction, inflammatory infiltration, and cartilage wear. Long-term improvements in joint lubrication, inflammation elimination, worn repair are crucial for effective RA treatment. Herein, we present an injectable bioadhesive lubricating hydrogel containing dopamine-modified hyaluronic acid (DA-HA) network, sulfonated (SO3−-HA) kartogenin (KGN)-grafted dopamine-hybridized graphene quantum dot-supported Cu single-atom nanozyme (DAGQD@Cu@KGN SAN) designed to restore RA. DA within the networks provides bioadhesion, allowing it persist cavity extended periods. The with SO3− group offer lubricity, reducing friction coefficient alleviating DAGQD@Cu@KGN SAN exhibits excellent superoxide dismutase, catalase, •OH scavenging activities, effectively inhibiting inflammation. KGN sustainably released from hydrogel, recruiting bone marrow mesenchymal stem cells damaged promoting their differentiation into chondrocytes. In vivo experimental results demonstrate that this not only prevents wear tear, providing long-term anti-oxidation anti-inflammatory effects early RA, but also repaired late-stage This bio-adhesive presents potential full-cycle strategy therapy. Injectable hydrogels being explored Arthritis therapy, most existing address specific aspects of pathological microenvironment. Here, authors report wear, effects, repairs

Language: Английский

NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma DOI

Xueyang Fang,

Rui Gong,

Decai Yang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(22), P. 15251 - 15263

Published: May 23, 2024

Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.

Language: Английский

Citations

23
Wearable Biodevices Based on Two-Dimensional Materials: From Flexible Sensors to Smart Integrated Systems DOI Creative Commons
Yingzhi Sun,

Weiyi He,

Can Jiang

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 15, 2025

Abstract The proliferation of wearable biodevices has boosted the development soft, innovative, and multifunctional materials for human health monitoring. integration sensors with intelligent systems is an overwhelming tendency, providing powerful tools remote monitoring personal management. Among many candidates, two-dimensional (2D) stand out due to several exotic mechanical, electrical, optical, chemical properties that can be efficiently integrated into atomic-thin films. While previous reviews on 2D primarily focus conventional configurations like graphene, rapid new opened up novel applications, particularly in smart interaction functionalities. This review aims consolidate recent progress, highlight unique advantages materials, guide future research by discussing existing challenges opportunities applying biodevices. We begin in-depth analysis advantages, sensing mechanisms, potential applications biodevice fabrication. Following this, we systematically discuss state-of-the-art based various physiological signals within body. Special attention given showcasing multi-functionality devices, mainly including self-power supply, diagnosis/treatment, human–machine interaction. Finally, concludes a concise summary prospective solutions concerning utilization advanced

Language: Английский

Citations

9
Charge separation by switching heterojunction system from Type-II to S-scheme for enhanced photocatalytic activity: Environmental detoxification and H2 production DOI
Zaina Algarni, Hakim S. Sultan Aljibori, Abdelfattah Amari

et al.

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 357, P. 130069 - 130069

Published: Oct. 12, 2024

Language: Английский

Citations

15
Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms DOI
Wenqi Wang, Peng Gao,

Hengshuo Gui

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205

Published: Sept. 11, 2024

Language: Английский

Citations

14
A multifunctional cascade enzyme system for enhanced starvation/chemodynamic combination therapy against hypoxic tumors DOI

Zihan Xing,

Linwei Li, Tao Liao

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 666, P. 244 - 258

Published: April 6, 2024

Language: Английский

Citations

9
Coordination engineering of FeCo dual single-atom nanozymes with photothermal-enhanced cascaded catalysis for efficient pancreatic cancer immunotherapy DOI

Wen-kuan Huang,

Zeyuan Zhang,

Jingqi Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154203 - 154203

Published: July 21, 2024

Language: Английский

Citations

8
The effect of nanoparticle agglomeration on the elastic and thermal properties of composites with an interphase DOI

Jing Pan,

Jinghong Liu, Xiaojian Liu

et al.

Mechanics Based Design of Structures and Machines, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Jan. 8, 2025

The interface plays a crucial role in nanoparticle-reinforced composite materials. So this article presents micromechanical model to predict the elastic and thermal properties of composites comprising nanoparticles encapsulated by an interphase. Nanoparticles are easy agglomerate matrix because their large surface area ratio. Therefore, study focuses on effect agglomeration modulus expansion coefficient (CTE). In present study, regions with concentrated particles assumed be spherical shape considered as inclusions. size efficiency factor is introduced reflect influence agglomerated inclusions diameter analysis. effects volume fractions, radius, degree nanoparticles, also thickness interphase studied detail. method used effective reinforced three-phase composites. Analysis shows that has significant reduces composites, but increases Increasing enhances while increasing particle radius Besides, more severe particles, larger will provide theoretical basis for preparation practical application

Language: Английский

Citations

1
Large amplitude vibration characteristic of the sandwich nanocomposite doubly curved shells DOI

Elyas Mohammad-Rezaei Bidgoli,

Mohammad Arefi

Archives of Civil and Mechanical Engineering, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 9, 2025

Language: Английский

Citations

1
Enhancing Peroxidase‐Like Activity and Photothermal Property of Copper Single‐Atom Nanozyme via A Cascade Competition Strategy DOI Open Access

Qiushuang Wu,

Guoan Zheng, Lihua Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract Single‐atom nanozymes (SANs) are promising enzyme‐active catalysts due to their maximum atomic utilization. However, it is still a challenge precisely regulate the single‐atom structure, especially in multimetallic MOFs. Based on Cu‐N 4 structure of Zn Cu 1 , cascade competition strategy mediated by buffer (polydopamine) proposed for first time, which induces one‐step nonthermal reaction remove inactive site and adjust coordination environment. Experimental results theoretical calculations show that nanozyme with 2 O (Cu‐N/O) breaks strong steric restriction, exposed active can better adsorb H making have peroxidase‐like activity. Compared traditional bimetallic (Cu ) monometallic (Cu‐MoF) nanozymes, has stronger catalytic activity photothermal properties, as well good photocatalytic extremely stability. It successfully applied Lateral flow immunoassay achieve three‐mode ultrasensitive detection Escherichia coli O157:H7, test strips after subjected broad‐spectrum sterilization treatment.

Language: Английский

Citations

1
Tumor Microenvironment‐Driven Structural Transformation of Vanadium‐Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy DOI Creative Commons
Hai Zhu, Tinghua Li, Xinhao Peng

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal efficiency and kinetics in the microenvironment (TME). Herein, this study draws inspiration from electronic structure transition metal vanadium, proposing leverage TME specific-features induce structural transformations sheet-like vanadium carbide MXenzymes (TVMz). These trigger cascading reactions that amplify oxidative stress, thereby significantly enhancing multimodal therapy. Specifically, engineered HTVMz, coated with hyaluronic acid, exhibits good stability generates thermal effect under NIR-II laser irradiation. The effect, combined characteristics, facilities transformation into ultra-small oxide nanozymes (VOx). enlarged surface area VOx substantially enhances ROS regeneration amplifies which promotes lysosomal permeability induces endoplasmic reticulum stress. high-valent interacts intracellular glutathione, disrupting redox homeostasis intensifying stress further. amplifications accelerate apoptosis, ferroptosis, suppress HSP90 expression. Consequently, heightened sensitivity HTVMz synergistically cell death via pathways. This presents an innovative strategy therapy by manipulating structures, advancing field

Language: Английский

Citations

1