International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136780 - 136780
Published: Oct. 1, 2024
Language: Английский
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154855 - 154855
Published: Aug. 14, 2024
Language: Английский
Citations
26
Nano Letters, Journal Year: 2024, Volume and Issue: 24(31), P. 9494 - 9504
Published: July 26, 2024
Chronic diabetic wound patients usually show high glucose levels and systemic immune disorder, resulting in reactive oxygen species (ROS) cell dysfunction, prolonged inflammation, delayed healing. Herein, we prepared an antioxidant immunomodulatory polymer vesicle for treatment. This is self-assembled from poly(ε-caprolactone)36-block-poly[lysine4-stat-(lysine-mannose)22-stat-tyrosine)16] ([PCL36-b-P[Lys4-stat-(Lys-Man)22-stat-Tyr16]). Polytyrosine polypeptide that can scavenge ROS. d-Mannose was introduced to afford functions by promoting macrophage transformation Treg activation through inhibitory cytokines. The mice treated with vesicles showed 23.7% higher a 91.3% M2/M1 ratio than those PBS. Animal tests confirmed this accelerated healing achieved complete of S. aureus-infected wounds within 8 days. Overall, the first scavenging ROS regulating homeostasis, opening new avenues effective
Language: Английский
Citations
12
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(30), P. 38989 - 39004
Published: July 22, 2024
Implant-associated infections and excessive immune responses are two major postsurgical issues for successful implantation. However, conventional strategies including antibiotic treatment inflammatory regulation always compromised due to the comodification of various biochemical agents instances functional interference. It is imperative provide implant surfaces with satisfactory antibacterial anti-inflammatory properties. Here, a dual-effect nanostructured polyetheretherketone (PEEK) surface (NP@PDA/Zn) bionic mechano-bactericidal nanopillars immobilized immunomodulatory Zn2+ designed. The constructed hybrid display remarkable performance against Gram-negative Gram-positive strains through synergy physical chemical bactericidal effects imposed by Zn2+. Meanwhile, immunoregulatory property evaluated investigation macrophage polarization both in vitro vivo, results reveal that NP@PDA/Zn could downregulate expression M1-related cytokines decrease M1 recruitment lower response. Notably, exhibited exceptional biocompatibility discerning biocidal activity between bacterial mammalian cells antioxidant effectively scavenges ROS, minimizing potential cytotoxicity. Taken together, presents convenient promising strategy combining synergistic without any mutual interference, which can support development multifunctional implant-associated materials.
Language: Английский
Citations
9
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 354, P. 123298 - 123298
Published: Jan. 23, 2025
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379
Published: Feb. 1, 2025
Language: Английский
Citations
1
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract Harnessing cross‐species regenerative cues to direct human potential is increasingly recognized as an excellent strategy in medicine, particularly for addressing the challenges of impaired wound healing aging populations. The skin mucus Andrias davidianus plays a critical role self‐protection and tissue repair, yet fundamental factors mechanisms involved remain elusive. Here, this work presents evidence that glycosaminoglycans (GAGs) derived from secretion (SAGs) serve potent mediators angiogenesis inflammatory remodeling, facilitating efficient diabetic wounds. Mechanistic studies reveal SAGs promote macrophage polarization toward anti‐inflammatory pro‐regenerative phenotype (CD206 + /Arg1 ) via glucolipid metabolic reprogramming. This process suppresses excessive inflammation enhances expression VEGF IL‐10 create facilitative microenvironment regeneration. Additionally, develops SAGs‐GelMA composite microspheres address multiple stages healing, including rapid hemostasis, exudate control, activation endogenous processes. engineered approach significantly improves scarless wounds by recruitment reparative macrophages. findings offer new insights into highlight therapeutic application repair.
Language: Английский
Citations
1
Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2818 - 2818
Published: Oct. 5, 2024
Hydrogels have emerged as promising candidates for biomedical applications, especially in the treatment of skin wounds, a result their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration smart-response features into hydrogels allows dynamic responses to different external or internal stimuli. Therefore, this paper reviews design smart-responsive microenvironments field wound therapy. First, three typical chronic difficult-to-heal wounds key mechanisms affecting healing therapeutic measures are outlined. Strategies construction stimulus-responsive (e.g., pH, ROS, enzymes, glucose) temperature, light, electricity, magnetic fields) highlighted from perspective microenvironment vitro environment, constitutive relationships between material design, intelligent response, revealed. Finally, discusses severe challenges faced by during repair provides an outlook on combination artificial intelligence give scientific direction creating using hydrogel dressings that respond stimuli clinic.
Language: Английский
Citations
8
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 98 - 109
Published: Aug. 28, 2024
Language: Английский
Citations
5
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 37 - 53
Published: Nov. 17, 2024
Language: Английский
Citations
5
Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123076 - 123076
Published: Dec. 31, 2024
Language: Английский
Citations
5