Porphyrin-based nanoscale metal–organic framework nanocarriers entrapping platinum nanoparticles and S-nitrosoglutathione for sonodynamic therapy in hypoxic tumors

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Sonodynamic therapy (SDT), which employs acoustic energy to generate reactive oxygen species (ROS), has emerged as a promising strategy for tumor treatment.

Language: Английский

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Nitric oxide-based multi-synergistic nanomedicine: an emerging therapeutic for anticancer

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 4, 2024

Gas therapy has emerged as a promising approach for treating cancer, with gases like NO, H2S, and CO showing positive effects. Among these, NO is considered key gas molecule significant potential in stopping cancer progression. However, due to its high reactivity short half-life, delivering directly tumors crucial enhancing treatment. NO-driven nanomedicines (NONs) have been developed effectively deliver donors tumors, great progress recent years. This review provides an overview of the latest advancements NO-based nanotherapeutics. It discusses types used current research, mechanisms action behind different delivery systems also explores combining other treatments enhanced therapy. Finally, it examines future prospects challenges using NONs clinical settings

Language: Английский

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Engineered Biomimetic Cancer Cell Membrane Nanosystems Trigger Gas‐Immunometabolic Therapy for Spinal‐Metastasized Tumors

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Despite great progress in enhancing tumor immunogenicity, conventional gas therapy cannot effectively reverse the immunosuppressive microenvironment (TIME), limiting immunotherapy. The development of therapeutic gases that are responsive and efficiently TIME for precisely targeted gas‐immunometabolic remains a challenge. In this study, novel cancer cell membrane‐encapsulated pH‐responsive nitric oxide (NO)‐releasing biomimetic nanosystem (MP@AL) is prepared. Lactate oxidase (Lox) MP@AL consumed oxygen to promote decomposition lactate, metabolic by‐product glycolysis, generation H 2 O , while L‐arginine (L‐Arg) oxidized by generate (NO). For one thing, NO led mitochondrial dysfunction cells reduce consumption efficiency Lox lactate decomposition, thus reversing lactate‐induced TIME; another, triggered immunogenic death, activated anti‐tumor immune response long‐term memory, ensured favorable effect synergistic interaction with PD‐L1 antibody inhibiting growth recurrence. Therefore, dual closed‐loop immunogenicity remodeling established. Overall, work will provide new ideas remodel enhance

Language: Английский

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Coordination catalysis of metals and polydopamine enables controlled release of CO from MnCO by enhancing oxidative stress and the thermal effect

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(16), P. 5196 - 5209

Published: Jan. 1, 2024

Coordination catalysis of Zn/Mn and polydopamine enhanced intracellular oxidative stress thermal effect, thus facilitated release CO from MnCO.

Language: Английский

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Facile fabrications of poly (acrylic acid)-mesoporous zinc phosphate/polydopamine Janus nanoparticles as a biosafe photothermal therapy agent and a pH/NIR-responsive drug carrier

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 328 - 339

Published: Aug. 23, 2024

Language: Английский

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Automatic metabolism modulator for glycolytic intervention‐induced cascade cancer therapy

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Effective intervention in glycolytic metabolism is a promising way to inhibit tumor malignant invasion. However, the inherent hypoxia environment and unitary regulating model subsequently compromise its therapeutic efficacy. Herein, facile design an automatic modulator (auto‐MMOD) developed by loading glucose oxidase (GOx) DNA‐templated silver nanoclusters (DNA‐AgNCs) into pH‐responsive zeolitic imidazolate frameworks‐8 (ZIF‐8) nanocarrier, which can activate cascaded metal ion‐killing effect during GOx‐regulated glycolysis metabolism. When acidic lysosome microenvironment induces ZIF‐8 decomposition, released GOx effectively consume generate H 2 O , thus inhibiting Adenosine Triphosphate synthesis accelerating starvation. Moreover, Ag + response disturb bioenergy proliferation, further enhances tumor‐killing hypoxic microenvironments. This study achieves effective suppression vitro vivo integrating ion therapy intervention, establish strategy for nano‐theranostics.

Language: Английский

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Mechanical shear flow regulates the malignancy of colorectal cancer cells

The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 40(7), P. 650 - 659

Published: May 17, 2024

Colorectal cancer (CRC) is notable for its high mortality and metastatic characteristics. The shear force generated by bloodstream provides mechanical signals regulating multiple responses of cells, including dispersing in blood vessels. We, therefore, studied the effect flow on circulating CRC cells present study. cell line SW620 was subjected to 12.5 dynes/cm

Language: Английский

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Peptide hydrogel based electrochemical biosensor for simultaneous monitoring of H2O2 and NO released from three-dimensional cultured breast cancer cells

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(9)

Published: Aug. 7, 2024

Language: Английский

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Charge Regulated pH/NIR Dual Responsive Nanoplatforms Centered on Cuproptosis for Enhanced Cancer Theranostics

Biomaterials, Journal Year: 2024, Volume and Issue: unknown, P. 122907 - 122907

Published: Oct. 1, 2024

Language: Английский

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Bionanoparticles with In Situ Nitric Oxide Release for Precise Modulation of ER‐TRPV1 Ion Channels in Multimodal Killing of Glioblastoma

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Glioblastoma (GBM) with highly immunosuppressive tumor microenvironment is a significant factor contributing to its treatment resistance and low survival rate. The activation of the transient receptor potential vanilloid 1 (TRPV1) ion channel, which overexpressed on endoplasmic reticulum (ER) GBM cells, governs control multi-organelle stress pathway branches inhibit expansion. Precise modulation ER-TRPV1 considered an effective strategy for inhibition GBM. As intracellular extracellular second messenger, nitric oxide (•NO) activates TRPV1 channel through nitrosylation cysteine residues. However, short lifespan limited range •NO makes it challenging achieve precise regulation ER-TRPV1. Herein, biomimetic upconversion nanoassembly (M-UCN-T) constructed, encapsulates organic donor coated homologous tumor-targeting cell membrane ER-targeting peptide. In response near-infrared light glutathione, M-UCN-T releases in situ activate channels. This study developed •NO-targeted release nanoplatform stepwise targeting functions, allow ER-TPRV1 •NO. approach induces signaling pathways, ultimately resulting multi-modal killing cells.

Language: Английский

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