Current roles of metals in arming sonodynamic cancer therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 521, P. 216169 - 216169

Published: Aug. 24, 2024

Language: Английский

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Photoactivation of cGAS-STING Pathway and Pyroptosis by Endoplasmic Reticulum-Targeting Ruthenium(II) Complex for Cancer Immunotherapy

Inorganic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A cholic acid-modified ruthenium( ii ) (Ru1) photosensitizer was synthesized. Ru1 induced pyroptosis and sequentially engaged the downstream proteins p-TBK1 p-IRF3 within STING pathway, thus promoting elicitation of tumor immune responses.

Language: Английский

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Recent progress in noble metal-based single-atom nanozymes for biomedical applications

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111731 - 111731

Published: Sept. 1, 2024

Language: Английский

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Mitoxantrone Combined with Engineered TRAIL‐Nanovesicles for Enhanced Cancer Immunotherapy Via Converting Apoptosis into Pyroptosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 24, 2024

Pyroptosis, a highly inflammatory form of programmed cell death, has emerged as promising target for cancer immunotherapy. However, in the context pyroptosis execution, while both caspase-3 and GSDME are essential, it is noteworthy that frequently under-expressed cold tumors. To overcome this limitation, engineered cellular nanovesicles (NVs) presenting TRAIL on their membranes (NV

Language: Английский

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Near Infrared‐Fluorescent Dinuclear Iridium(III) Nanoparticles for Immunogenic Sonodynamic Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: July 31, 2024

Abstract Dinuclear iridium(III) complexes activated by light‐inducible spatiotemporal control are emerging as promising candidates for cancer therapy. However, broader applications of current light‐activated dinuclear limited the ineffective tissue penetration and undesirable feedback on guidance activation. Here, an ultrasound (US) triggered near infrared‐fluorescent nanoparticle, NanoIr, is first reported to precisely spatiotemporally inhibit tumor growth. It demonstrated that reactive oxygen species can be generated NanoIr upon exposure US irradiation (NanoIr + US), thereby inducing immunogenic cell death. When combined with cisplatin, elicits synergistic effects in patient‐derived xenograft mice models ovarian cancer. This work provides a design nanoparticles sonodynamic

Language: Английский

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A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

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Integrin‐Targeted, Activatable Nanophototherapeutics for Immune Modulation: Enhancing Photoimmunotherapy Efficacy in Prostate Cancer Through Macrophage Reprogramming

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

ABSTRACT Prostate cancer is an epithelial malignancy with a high incidence among elderly men. Photochemistry‐based dye photodrugs (known as photosensitizers) offer promising clinical approach for treating tumors. These agents work by inducing immunogenic cell death (ICD), which activates antitumor immune response. This favored owing to its minimal invasiveness, low toxicity, and efficiency. However, the immunosuppressive microenvironment of characteristics “cold” tumors significantly restricts efficacy photodrugs. Developing advanced nanocarrier system deliver agonists efficient drug delivery tumor lesion sites reshape crucial in practice. Therefore, this study, we designed integrin‐targeted, activatable nano photodrug co‐assembly agonist (RPST@IMQ) enhancing photoimmunotherapy prostate via reprogramming tumor‐associated macrophages. The active‐targeted nanosystem enhanced dosage at site through systemic administration. High doses glutathione cleaved disulfide bonds RPST@IMQ, releasing imiquimod (IMQ). Under photoirradiation, generated significant singlet oxygen eliminate cells, thereby ICD activate responses. Simultaneously, released IMQ reprograms M2‐type macrophages (TAMs) into M1‐type TAMs tumor‐killing capabilities, converting “hot” conversion enhances therapeutic against primary distant vivo. study offers new insights development innovative, smart, enhance anticancer outcomes.

Language: Английский

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Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO₃ Piezoelectric Nanomaterials in Tumor Treatment

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.

Language: Английский

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A Dual Stimuli-Responsive Nanoimmunomodulator for Antitumor Synergy of Macrophages and T Cells

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Only a minority of patients benefit from current T-cell-focused adaptive immunotherapies, underscoring the need to engage innate immune cells, particularly macrophages, for multilayered tumor control. However, high-efficacy therapeutics capable orchestrating multiple cells remain scarce. Herein, dual stimuli-responsive nanoimmunomodulator (6EPP@si) that caters specifically microenvironment (TME) is presented antitumor synergy macrophages and T cells. Using functional polymer-based carrier, we co-deliver endoplasmic reticulum (ER)-localized photosensitizer 6E small interfering RNA targeting CD47 (siCD47) into breast tumors. Within acidic high-glutathione TME, 6EPP@si undergoes self-lysosome escape nanocleavage precise, on-demand drug release. Consequently, siCD47 released cytoplasm enables potent silencing, while ER-targeted induces immunogenic cell death through reactive oxygen species-based ER stress, triggering release damage-associated molecular patterns, including calreticulin surface translocation. enhances macrophage phagocytosis by modulating both antiphagocytic prophagocytic signals also promotes antigen presentation activate In orthotopic spontaneous lung metastatic models, this combined approach demonstrates robust effects effective antimetastatic immunity, offering meaningful strategy simultaneously enhancing cancer immunotherapy.

Language: Английский

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Charge separation engineering modulates self-oxygenating nano-heterojunctions to induce ferroptosis for sonodynamic-immunotherapy of tumors

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160713 - 160713

Published: Feb. 1, 2025

Language: Английский

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