Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Microneedle
patches
have
emerged
as
a
promising
approach
for
diabetic
wound
healing
by
enabling
the
targeted
delivery
of
therapeutic
agents
such
stem
cells
and
their
derived
exosomes,
well
localized
bioactive
moieties.
These
offer
non-invasive
efficient
method
administering
payloads
directly
to
site
wound,
bypassing
systemic
circulation
minimizing
potential
side
effects.
The
holds
immense
promoting
tissue
regeneration
accelerating
in
patients.
Similarly,
cell-derived
which
are
known
regenerative
anti-inflammatory
properties,
can
enhance
process.
Furthermore,
microneedle
enable
precise
controlled
release
moieties,
growth
factors
cytokines,
site,
creating
conducive
microenvironment
repair
regeneration.
challenges
associated
with
multifaceted.
Biocompatibility
issues,
variability
skin
characteristics
among
patients,
regulatory
hurdles,
scalability,
cost
considerations,
long-term
stability,
patient
acceptance
compliance
all
present
significant
barriers
widespread
adoption
optimization
technology
clinical
practice.
Overcoming
these
will
require
collaborative
efforts
from
various
stakeholders
advance
field
address
critical
gaps
research
development.
Ongoing
focuses
on
enhancing
biocompatibility
mechanical
properties
materials,
developing
customizable
technologies
personalized
treatment
approaches,
integrating
advanced
functionalities
sensors
real-time
monitoring,
improving
engagement
adherence
through
education
support
mechanisms.
advancements
improve
management
providing
tailored
therapies
that
promote
faster
reduce
complications.
This
review
explores
current
landscape
context
management,
highlighting
both
need
be
addressed
future
perspectives
this
innovative
modality.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(39), P. 26733 - 26750
Published: Sept. 6, 2024
Rescuing
or
compensating
mitochondrial
function
represents
a
promising
therapeutic
avenue
for
radiation-induced
chronic
wounds.
Adult
stem
cell
efficacies
are
primarily
dependent
on
the
paracrine
secretion
of
mitochondria-containing
extracellular
vesicles
(EVs).
However,
effective
strategies
addressing
quantity
mitochondria
and
mitochondria-delivery
system
lacking.
Thus,
in
this
study,
we
aimed
to
design
an
hydrogel
microneedle
patch
(MNP)
loaded
with
cell-derived
mitochondria-rich
EVs
gradually
release
deliver
into
wound
tissues
boost
healing.
We,
first,
used
metformin
enhance
biogenesis
thereby
increasing
(termed
"Met-EVs")
adipose-derived
cells.
To
verify
effects
Met-EVs,
established
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
Diabetic
wounds
are
highly
susceptible
to
bacterial
infection,
which
can
lead
the
formation
of
biofilms,
making
diabetic
wound
healing
a
major
challenge.
In
this
study,
composited
microneedle
that
incorporated
drug-loaded
conjugated
polymer
nanoparticles
and
basic
fibroblast
growth
factor
was
prepared
eliminate
biofilms
promote
vascular
regeneration.
This
released
minocycline
under
near-infrared
(NIR)
light,
effectively
penetrating
biofilms.
The
photothermal
properties
polymers,
combined
with
antibacterial
action
minocycline,
contribute
eradication
elimination
drug-resistant
bacteria.
Moreover,
it
regulated
microenvironment
by
reducing
level
oxidative
stress,
as
well
production
inflammatory
factors
at
site.
Meanwhile,
boosted
cell
migration
promoted
angiogenesis
accelerate
healing.
for
biofilm
represents
promising
approach
promoting
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Diabetic
foot
ulcer
typically
undergoes
a
delayed
wound‐healing
process
owing
to
the
disordered
microenvironment,
including
persistent
inflammation,
long‐term
hypoxia,
and
excessive
fibrosis,
eventually
leading
severe
disabilities
other
poor
outcomes.
However,
current
strategies
cannot
meet
dynamic
demands
during
process.
Herein,
reactive
oxygen
species
(ROS)–responsive
oxygen‐generating
microneedle
platform,
consisting
of
sericin‐based
glucose‐responsive
hydrogel
loaded
with
verteporfin,
for
effective
diabetic
wound
healing
is
proposed.
Under
highly
oxidative
functionalized
sericin
protein
depletes
overproduced
ROS
generate
oxygen,
which
can
not
only
alleviate
hypoxic
microenvironment
promote
angiogenesis
by
activating
extracellular
signal‐regulated
kinase
Heme
Oxygenase‐1
pathways
but
also
decrease
expression
proinflammatory
cytokines.
Moreover,
hyperglycaemic
condition
triggers
gradual
dissociation
this
platform
promotes
release
verteporfin
enhance
scarless
re‐epithelization
via
inhibiting
yes‐associated
signal.
This
versatile
system
integrates
advantageous
features
inflammation
alleviation,
promotion,
scar
inhibition
capabilities,
accelerates
repair
in
vivo,
offers
novel
approach
self‐supply
remodeling.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(8), P. 4771 - 4790
Published: July 10, 2024
Microneedles
are
a
novel
drug
delivery
system
that
offers
advantages
such
as
safety,
painlessness,
minimally
invasive
administration,
simplicity
of
use,
and
controllable
delivery.
As
type
polymer
microneedle
with
three-dimensional
network
structure,
hydrogel
microneedles
(HMNs)
possess
excellent
biocompatibility
biodegradability
encapsulate
various
therapeutic
drugs
while
maintaining
activity,
thus
attracting
significant
attention.
Recently,
they
have
been
widely
employed
to
promote
wound
healing
demonstrated
favorable
effects.
Although
there
reviews
about
HMNs,
few
them
focus
on
management.
Herein,
we
present
comprehensive
overview
the
design
preparation
methods
particular
emphasis
their
application
status
in
healing,
including
acute
infected
diabetic
scarless
healing.
Finally,
examine
limitations
HMNs
management
provide
suggestions
for
future
research
directions.
Islet
transplantation
has
now
become
a
promising
treatment
for
insulin-deficient
diabetes
mellitus.
Compared
to
traditional
treatments,
cell
therapy
can
restore
endogenous
insulin
supplementation,
but
its
large-scale
clinical
application
is
impeded
by
donor
shortages,
immune
rejection,
and
unsuitable
sites.
To
overcome
these
challenges,
an
increasing
number
of
studies
have
attempted
transplant
hydrogel-encapsulated
islet
cells
treat
diabetes.
This
review
mainly
focuses
on
the
strategy
pancreatic
diabetic
therapy,
including
different
sources
encapsulated
in
hydrogels,
encapsulation
methods,
hydrogel
types,
series
accessorial
manners
improve
outcomes.
In
addition,
formation
challenges
as
well
prospects
are
also
presented.
