Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 26, 2024
Abstract
Temporomandibular
joint
osteoarthritis
(TMJ-OA)
is
a
common
disease
often
accompanied
by
pain,
seriously
affecting
physical
and
mental
health
of
patients.
Abnormal
innervation
at
the
osteochondral
junction
has
been
considered
as
predominant
origin
arthralgia,
while
specific
mechanism
mediating
pain
remains
unclear.
To
investigate
underlying
TMJ-OA
an
abnormal
loading
model
was
used
to
induce
pain.
We
found
that
during
development
TMJ-OA,
increased
sympathetic
nerve
subchondral
bone
precedes
sensory
nerves.
Furthermore,
these
two
types
nerves
are
spatially
closely
associated.
Additionally,
it
discovered
activation
neural
signals
promotes
osteoarthritic
in
mice,
whereas
blocking
effectively
alleviates
In
vitro
experiments
also
confirmed
norepinephrine
released
neurons
axonal
growth
neurons.
Moreover,
we
through
releasing
norepinephrine,
regional
were
regulate
local
synergistically
with
other
regulators.
This
study
identified
role
TMJ-OA.
It
sheds
light
on
new
crosstalk
between
peripheral
nerves,
providing
potential
target
for
treating
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: June 2, 2024
Abstract
Hydrogels
are
dynamically
evolving
3D
networks
composed
of
hydrophilic
polymer
scaffolds
with
significant
applications
in
the
healthcare
and
environmental
sectors.
Notably,
protein‐based
hydrogels
mimic
extracellular
matrix,
promoting
cell
adhesion.
Further
enhancing
proliferation
within
these
matrix‐metalloproteinase‐triggered
amino
acid
motifs.
Integration
cell‐friendly
modules
like
peptides
proteins
expands
hydrogel
functionality.
These
exceptional
properties
position
for
diverse
applications,
including
biomedicine,
biosensors,
remediation,
food
industry.
Despite
progress,
there
is
ongoing
research
to
optimize
biomedical
further.
Engineering
novel
favorable
characteristics
crucial
regulating
tissue
architecture
facilitating
ecological
remediation.
This
review
explores
synthesis,
physicochemical
properties,
biological
implications
various
types
their
extensive
biomedicine
It
elaborates
on
potential
bridging
gap
between
advancements
sector
solutions
issues.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 6, 2025
Abstract
Treating
osteoarthritis
(OA)
associated
pain
is
a
challenge
with
the
potential
to
significantly
improve
patients
lives.
Here,
we
report
on
hydrogel
for
extracellular
RNA
scavenging
and
releasing
bevacizumab
block
neurovascularization
at
osteochondral
interface,
thereby
mitigating
OA
disease
progression.
The
formed
by
cross-linking
aldehyde-phenylboronic
acid-modified
sodium
alginate/polyethyleneimine-grafted
protocatechuic
acid
(OSAP/PPCA)
sustained-release
nanoparticles
(BGN@Be),
termed
OSPPB.
dynamic
Schiff
base
bonds
boronic
ester
allow
injectability,
self-healing,
pH/reactive
oxygen
species
dual
responsiveness.
OSPPB
can
inhibit
angiogenesis
neurogenesis
in
vitro.
In
an
vivo
model,
intraarticular
injection
of
accelerates
healing
process
condyles
alleviates
chronic
inhibiting
interface.
injectable
represents
promising
technique
treat
pain.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Periodontitis
is
a
chronic
inflammatory
condition
affecting
the
periodontal
tissue.
This
worsens
in
diabetic
patients
due
to
oxidative
stress
and
inflammation.
Herein,
we
investigated
treatment
using
bioactive
Zn–V–Si–Ca
glass
nanoparticle
hydrogel
microneedles.
The
microneedles
contain
nanoparticles
codoped
with
zinc
vanadium
ions.
They
also
include
gallic
acid
oxidized
methacrylated
hyaluronic
acid.
These
address
bacterial
dysbiosis
periodontitis.
provide
antibacterial
antioxidant
effects.
deliver
therapeutic
agents
directly
into
gingival
enhances
drug
retention
absorption
by
penetrating
mucosal
barrier.
In
vitro
studies
demonstrated
biocompatibility,
excellent
properties,
acceptable
mechanical
properties.
Meanwhile,
microneedle
patches
properties
effective
against
Gram-negative
pathogen
as
well
Gram-positive
oral
bacterium.
vivo
experiments
were
performed
rat
model
Results
showed
significant
improvement
alveolar
bone
regeneration.
modulated
microenvironment
effectively.
Ribonucleic
sequencing
revealed
downregulation
of
JAK-STAT
NF-κB
inflammation
signaling
pathways.
work
presents
distinctive
approach
suppressing
response
modulate
immune
responses
for
purpose
treating
periodontitis
early.
Military Medical Research,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: March 3, 2025
Abstract
Bone
tissue
relies
on
the
intricate
interplay
between
blood
vessels
and
nerve
fibers,
both
are
essential
for
many
physiological
pathological
processes
of
skeletal
system.
Blood
provide
necessary
oxygen
nutrients
to
bone
tissues,
remove
metabolic
waste.
Concomitantly,
fibers
precede
during
growth,
promote
vascularization,
influence
cells
by
secreting
neurotransmitters
stimulate
osteogenesis.
Despite
critical
roles
components,
current
biomaterials
generally
focus
enhancing
intraosseous
vessel
repair,
while
often
neglecting
contribution
nerves.
Understanding
distribution
main
functions
in
is
crucial
developing
effective
engineering.
This
review
first
explores
anatomy
highlighting
their
vital
embryonic
development,
metabolism,
repair.
It
covers
innovative
regeneration
strategies
directed
at
accelerating
intrabony
neurovascular
system
over
past
10
years.
The
issues
covered
included
material
properties
(stiffness,
surface
topography,
pore
structures,
conductivity,
piezoelectricity)
acellular
biological
factors
[neurotrophins,
peptides,
ribonucleic
acids
(RNAs),
inorganic
ions,
exosomes].
Major
challenges
encountered
neurovascularized
materials
clinical
translation
have
also
been
highlighted.
Furthermore,
discusses
future
research
directions
potential
developments
aimed
producing
repair
that
more
accurately
mimic
natural
healing
tissue.
will
serve
as
a
valuable
reference
researchers
clinicians
novel
into
practice.
By
bridging
gap
experimental
practical
application,
these
advancements
transform
treatment
defects
significantly
improve
quality
life
patients
with
bone-related
conditions.
International Journal of Oral Science,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 6, 2025
Abstract
Temporomandibular
joint
osteoarthritis
(TMJ-OA)
is
a
common
disease
often
accompanied
by
pain,
seriously
affecting
physical
and
mental
health
of
patients.
Abnormal
innervation
at
the
osteochondral
junction
has
been
considered
as
predominant
origin
arthralgia,
while
specific
mechanism
mediating
pain
remains
unclear.
To
investigate
underlying
TMJ-OA
an
abnormal
loading
model
was
used
to
induce
pain.
We
found
that
during
development
TMJ-OA,
increased
sympathetic
nerve
subchondral
bone
precedes
sensory
nerves.
Furthermore,
these
two
types
nerves
are
spatially
closely
associated.
Additionally,
it
discovered
activation
neural
signals
promotes
osteoarthritic
in
mice,
whereas
blocking
effectively
alleviates
In
vitro
experiments
also
confirmed
norepinephrine
released
neurons
axonal
growth
neurons.
Moreover,
we
through
releasing
norepinephrine,
regional
were
regulate
local
synergistically
with
other
regulators.
This
study
identified
role
TMJ-OA.
It
sheds
light
on
new
crosstalk
between
peripheral
nerves,
providing
potential
target
for
treating
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Direct
ink
writing
(DIW)
is
an
additive
manufacturing
technique
that
has
garnered
notable
interest
due
to
its
precise
and
consistent
printing
of
a
wide
range
materials,
such
as
viscoelastic
hydrogels,
pastes,
complex
composites,
by
adjusting
the
ink's
rheology.
This
material
flexibility
combined
with
ability
print
at
room
temperature
makes
DIW
ideal
for
diverse
applications
scalable
from
small
industrial
levels.
In
recent
years,
conductive
hydrogels
gained
significant
attention
across
various
fields,
ranging
biomedical
scaffolds
flexible
electronics.
Conductive
are
category
which
exhibit
conductivity
in
their
wet
and/or
dry
state.
Precursors
like
polymers,
metallic
nanoparticles,
carbon‐based
materials
can
be
used
induce
electronic
ionic
hydrogels.
review
presents
comprehensive
overview
demonstrating
printability
using
technique.
The
fundamentals
precursors
presented.
Following,
different
pathways
reaching
optimal
hydrogel
properties,
including
mechanical,
conductive,
rheological,
focus
on
synthesis
introduced.
Finally,
emerging
electronics
medicine
highlighted,
anticipated
challenges
advancement
printable
discussed.
The
rapid
increase
in
the
number
of
stimuli-responsive
polymers,
also
known
as
smart
has
significantly
advanced
their
applications
various
fields.
These
polymers
can
respond
to
multiple
stimuli,
such
temperature,
pH,
solvent,
ionic
strength,
light,
and
electrical
magnetic
fields,
making
them
highly
valuable
both
academic
industrial
sectors.
Recent
studies
have
focused
on
developing
hydrogels
with
self-healing
properties
that
autonomously
recover
structural
integrity
mechanical
after
damage.
hydrogels,
formed
through
dynamic
covalent
reactions,
exhibit
superior
biocompatibility,
responsiveness
particularly
pH
changes.
However,
conventional
are
limited
by
weak
brittle
nature.
To
address
this,
ionizable
moieties
within
polyelectrolytes
be
tuned
create
ionically
cross-linked
leveraging
natural
alginate,
chitosan,
hyaluronic
acid,
cellulose.
integration
liquids
into
these
enhances
conductivity,
positioning
significant
agents.
This
review
focuses
emerging
field
ionic-based
explores
potential
dermal
tissue
engineering.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 25, 2024
Hydrogels
are
well-suited
for
biomedical
applications
due
to
their
numerous
advantages,
such
as
excellent
bioactivity,
versatile
physical
and
chemical
properties,
effective
drug
delivery
capabilities.
Recently,
hydrogel
coatings
have
developed
functionalize
bone
implants
which
biologically
inert
cannot
withstand
the
complex
tissue
repair
microenvironment.
These
shown
promise
in
addressing
unique
pressing
medical
needs.
This
review
begins
with
major
functionalized
performance
interfacial
bonding
strategy
of
coatings,
a
focus
on
novel
external
field
response
properties
hydrogel.
Recent
advances
fabrication
strategies
use
treatment
pathologic
regeneration
highlighted.
Finally,
challenges
emerging
trends
evolution
application
physiological
environment-responsive
electric
field-responsive
discussed.
