Self-assembled nanodrug based on ferroptosis inducer and sonosensitizer for enhanced sonodynamic-triggered multimodal synergistic therapy of prostate cancer

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: 208, P. 114656 - 114656

Published: Feb. 3, 2025

Language: Английский

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Z-scheme promoted interfacial charge transfer on Cu/In-porphyrin MOFs/CdIn2S4 heterostructure for efficient photocatalytic H2 evolution

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 354, P. 129220 - 129220

Published: Aug. 14, 2024

Language: Английский

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Recent progress of porphyrin metal-organic frameworks for combined photodynamic therapy and hypoxia-activated chemotherapy

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(93), P. 13641 - 13652

Published: Jan. 1, 2024

Hypoxia limits the phototherapeutic efficacy of porphyrin-based nMOFs; loading with hypoxia-activated drug TPZ enhances combined PDT and chemotherapy effects.

Language: Английский

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Acid‐Responsive Nanoregulators Elicit Hydrogen Sulfide‐Mediated Tumor Oxygenation and Selective Sonosensitization for Hypoxic Tumors

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Oxygen (O 2 ) tension within a tumor is considered hallmark of sonodynamic therapy (SDT). Herein, multifunctional nanoregulators, CMCS‐Au‐SrS (CAS), are reported, which assembled by carboxymethyl chitosan(CMCS) tethered gold nanoclusters (Au NCs) as sonosensitizers and sulfurate donors strontium sulfide nanoparticles (SrS NPs), to evoke selective SDT in hypoxic tumors. CAS possess tumor‐acidity responsiveness form large‐size aggregated Au NCs with shortened bandgap so that effectively induce powerful reactive oxygen species generation. On the other hand, acidity triggers degradation SrS NPs release hydrogen (H S), evoking oxygenation overcome hypoxia. This junction accelerated sonosensiting ability boosts amplified efficacy. More importantly, specific glycolysis induced acidification leads selectively accumulated cancer cells, further guaranteeing execution advanced therapeutic manners. Additionally, doping Nd 3+ endows second near‐infrared fluorescence facilitate vivo tracing property good tissue penetration (up 6 mm). strategy may play pioneering role develop theranostic reagents improved enrichment capacity enhanced hypoxia

Language: Английский

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Thienylquinoline-Based Ionic Iridium(III) Complexes as Highly Efficient Sonosensitizers for Sonodynamic Therapy

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123547 - 123547

Published: Jan. 1, 2025

Language: Английский

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Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO₃ Piezoelectric Nanomaterials in Tumor Treatment

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.

Language: Английский

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Recent Advances in Glutathione Depletion-Enhanced Porphyrin-Based nMOFs for Photodynamic Therapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 244 - 244

Published: Feb. 12, 2025

Photodynamic therapy has established itself as a clinical treatment for certain superficial cancers by converting oxygen into cytotoxic singlet to eradicate cancer cells. Porphyrin-based nanoscale metal-organic frameworks have emerged promising photosensitive platforms due their ability prevent the hydrophobic aggregation quenching of porphyrin molecules and enhance accumulation at tumor site, thereby becoming focal point in photodynamic materials research. However, elevated levels glutathione other reductive substances within cells can alleviate oxidative stress induced from process, thus protecting intracellular biomolecular structures damage. Consequently, it is crucial design functionalized nanoplatforms that integrate depletion with porphyrin-based significantly boost efficacy. Moreover, excess disrupt structure frameworks, which not only increases capacity generate upon light exposure but also aids recovery fluorescence imaging capabilities. Additionally, this specificity minimizes photosensitizing harm normal tissues. This review compiles recent advancements developing enhanced phototherapy through depletion. It aims promote further application provide valuable insights preclinical applications. By highlighting strategies improve therapeutic outcomes while maintaining safety profiles, summary seeks advance development more effective targeted treatments.

Language: Английский

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Charge separation engineering modulates self-oxygenating nano-heterojunctions to induce ferroptosis for sonodynamic-immunotherapy of tumors

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160713 - 160713

Published: Feb. 1, 2025

Language: Английский

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Synergistic polyphenol–amino acid nanoparticles: a new strategy for reactive oxygen species management

RSC Advances, Journal Year: 2025, Volume and Issue: 15(7), P. 5117 - 5123

Published: Jan. 1, 2025

Polyphenols exhibit strong antioxidant, and anti-inflammatory but are limited by chemical instability low bioavailability. To address these challenges, we developed polyphenol-amino acid conjugates that self-assemble into stable nanospheres, enhancing their stability These nanoparticles demonstrate significantly improved ROS scavenging efficiency promote cell proliferation in vitro. The incorporation of amino acids enhances biocompatibility facilitates effective elimination. offer a multifaceted therapeutic strategy to mitigate oxidative stress, overcoming traditional antioxidant limitations through advanced nanotechnology. This approach contributes the development next-generation wound care solutions with enhanced efficacy safety profiles.

Language: Английский

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Editing Benzotrithiophene-Based Covalent Organic Frameworks for Developing New Sonosensitizers

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Recent insights into covalent organic frameworks (COFs) provide an opportunity for developing new sonosensitizers with the advantages of both small molecules and inorganic nanoagents. Herein, we synthesize two benzotrithiophene-based imine-linked COFs (BTT-DPh-COF BTT-DPy-COF) through density-functional-theory-guided structure editing. The tailored donor-acceptor (D-A) structures optimize band position endow them good intrinsic sonodynamic activity, which can efficiently kill cancer cells, showing excellent therapeutic effect. Particularly, because enhanced D-A effect that promotes charge separation transfer behavior, BTT-DPy-COF exhibits superior ultrasound-triggered reactive oxygen species (ROS) generation capability than BTT-DPh-COF. Therefore, these studies highlight great potential elaborate editing configurations as suitable candidates advanced sonosensitizers.

Language: Английский

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