Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
97(1), P. 565 - 573
Published: Dec. 27, 2024
The
surge
of
lateral
flow
immunoassays
(LFAs)
stimulates
researchers
to
explore
the
novel
vibrant
aggregation-induced
emission
luminogen
(AIEgen)-doped
nanoparticles
improve
accuracy
and
reliability
LFAs.
However,
loading
amount
AIEgens
currently
used
for
LFA
in
microspheres
is
limited
due
their
symmetrical
large
conjugated
skeleton
structure,
which
significantly
reduces
fluorescence
brightness
signal
reporter
LFA.
Herein,
an
ionic
with
a
donor–acceptor
type
was
developed
as
C-reactive
protein
(CRP).
Ionic
are
unable
enter
hydrophobic
cavity
polystyrene
(PS)
because
low
nature.
By
altering
extended
alkyl
chains,
it
possible
increase
hydrophobicity,
thereby
potentially
increasing
capacity
within
PS.
Notably,
fluorescent
(denoted
AIETPANPs)
formed
by
embedding
(E)-4-(4-(diphenylamino)styryl)-1-octadecylpyridin-1-ium
iodide
(TPA)
PS
showed
orange-red
have
high
quantum
yield.
Anti-CRP
antibody
(mAb1)
could
be
effectively
surface
AIETPANPs
amino-carboxyl
reaction,
resulting
AIETPANPs-mAb1.
AIETPANPs-mAb1
exhibited
at
613
nm,
point
detectable
naked
eye
minimal
background
interference.
entire
analysis
accomplished
just
10
min,
achieving
limit
detection
4.06
ng/mL
CRP.
AIETPANPs-mAb1-based
demonstrates
excellent
stability
specificity
fully
meets
requirements
clinical
diagnosis.
Advanced Energy Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 26, 2025
Abstract
Developing
cost‐effective
hydrogen
evolution
reactions
(HER)
catalysts
to
replace
Pt/C
in
alkaline
seawater
media
remains
a
critical
challenge.
Therefore,
the
osmium‐osmium
phosphide
(Os‐OsP
2
)
catalyst
is
reported
with
heterogeneous
junction
through
ultrafast
(20
s)
microwave
quasi‐solid
approach
for
seawater‐splitting
under
industrial‐grade
current
density.
Experimental
and
theoretical
analysis
reveal
that
Os‐OsP₂
interface
optimizes
electronic
structure:
osmium
(Os)
sites
accelerate
water
dissociation
by
lowering
d‐band
center,
while
OsP₂
promotes
desorption
via
interfacial
spillover,
collectively
reducing
HER
energy
barrier.
In
addition,
requires
only
1.74
V
reach
1
A
cm
−2
owns
high
price
activity
anion
exchange
membrane
electrolyzer,
surpassing
commercial
23%
efficiency
identical
conditions.
Furthermore,
it
exhibits
robust
across
wide
pH
range
exceptional
durability
over
100
h
seawater.
Economic
evaluation
highlights
its
superior
cost
(85.6
dollar⁻¹),
90‐fold
higher
than
Pt/C,
production
costs
($0.86
GGE⁻¹)
undercutting
U.S.
DOE
target.
This
study
provides
feasible
guidance
development
of
high‐performance,
scalable
from
The
integration
of
chemical
catalysts
and
biocatalysts
into
catalytic
cascade
reactions
has
garnered
significant
attention
in
recent
years.
However,
its
practical
application
been
limited
due
to
several
challenges,
including
the
fragility
enzymes,
inadequate
carrier
loading
capacity,
poor
efficiency.
In
this
study,
two
types
Fe-ion-coordinated
covalent
organic
frameworks
(Fe-COFs)
were
synthesized
one
pot
by
facilely
changing
COF
monomers.
They
have
similar
topologies
but
different
electronic
structures
on
sites.
These
Fe-COFs
demonstrated
excellent
peroxidase
activity
without
interference
oxidase
activity,
making
them
suitable
for
immobilization
glucose
(GOx).
It
is
proved
that
both
could
achieve
a
high
GOx
capacity
over
0.9
mg/mgCOF.
general
applicability
as
carriers
construction
systems
was
confirmed.
Among
them,
Fe-COF1
constructed
2,2'-bipyridine-5,5'-diformaldehyde
(Bpy)
1,3,6,8-tetrakis(p-aminophenyl)-pyrene
(Tpy)
optimized
more
toward
quantitative
colorimetric
determination
trace
glucose.
Building
upon
this,
nanoenzyme-based
sensor
compatible
with
smartphone
biological
developed,
facilitating
efficient
convenient
quantification.
strong
linear
relationship
within
concentration
range
10-1000
μM,
limit
detection
(LoD)
1.4
μM.
Additionally,
it
retained
90%
after
10
repeated
tests,
proving
efficacy
sensitively
detecting
serum
samples.
This
work
expands
applications
biocascade
based
COFs
sensing
medical
diagnostics.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
97(1), P. 565 - 573
Published: Dec. 27, 2024
The
surge
of
lateral
flow
immunoassays
(LFAs)
stimulates
researchers
to
explore
the
novel
vibrant
aggregation-induced
emission
luminogen
(AIEgen)-doped
nanoparticles
improve
accuracy
and
reliability
LFAs.
However,
loading
amount
AIEgens
currently
used
for
LFA
in
microspheres
is
limited
due
their
symmetrical
large
conjugated
skeleton
structure,
which
significantly
reduces
fluorescence
brightness
signal
reporter
LFA.
Herein,
an
ionic
with
a
donor–acceptor
type
was
developed
as
C-reactive
protein
(CRP).
Ionic
are
unable
enter
hydrophobic
cavity
polystyrene
(PS)
because
low
nature.
By
altering
extended
alkyl
chains,
it
possible
increase
hydrophobicity,
thereby
potentially
increasing
capacity
within
PS.
Notably,
fluorescent
(denoted
AIETPANPs)
formed
by
embedding
(E)-4-(4-(diphenylamino)styryl)-1-octadecylpyridin-1-ium
iodide
(TPA)
PS
showed
orange-red
have
high
quantum
yield.
Anti-CRP
antibody
(mAb1)
could
be
effectively
surface
AIETPANPs
amino-carboxyl
reaction,
resulting
AIETPANPs-mAb1.
AIETPANPs-mAb1
exhibited
at
613
nm,
point
detectable
naked
eye
minimal
background
interference.
entire
analysis
accomplished
just
10
min,
achieving
limit
detection
4.06
ng/mL
CRP.
AIETPANPs-mAb1-based
demonstrates
excellent
stability
specificity
fully
meets
requirements
clinical
diagnosis.
