Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 14, 2024
The
integration
of
photoacoustic
imaging
(PAI)
and
photothermal
therapy
(PTT)
within
the
second
near-infrared
(NIR-II)
window,
offering
a
combination
high-resolution
precise
non-invasive
thermal
ablation,
presents
an
attractive
opportunity
for
cancer
treatment.
Despite
significant
promise,
development
this
noninvasive
phototheranostic
nanomedicines
encounters
challenges
that
stem
from
tumor
thermotolerance
limited
therapeutic
efficacy.
In
contribution,
we
designed
amphiphilic
semiconducting
polymer
brush
(SPB)
featuring
thermosensitive
carbon
monoxide
(CO)
donor
(TDF-CO)
NIR-II
PAI-assisted
gas-augmented
deep-tissue
PTT.
TDF-CO
nanoparticles
(NPs)
exhibited
powerful
conversion
efficiency
(43.1%)
capacity
to
trigger
CO
release
after
photoirradiation.
Notably,
liberated
not
only
acts
on
mitochondria,
leading
mitochondrial
dysfunction
promoting
cellular
apoptosis
but
also
hinders
overexpression
heat
shock
proteins
(HSPs),
enhancing
tumor's
thermosensitivity
This
dual
action
accelerates
achieving
synergistic
effect
in
Intravenous
administration
NPs
4T1
tumor-bearing
mice
demonstrated
bright
PAI
signals
remarkable
ablation
under
1064
nm
laser
irradiation,
underscoring
potential
CO-mediated
photothermal/gas
therapy.
We
envision
tailor-made
multifunctional
light-triggered
SPB
provides
feasible
approach
amplify
performance
PTT
advancing
future
phototheranostics.
Small,
Journal Year:
2024,
Volume and Issue:
20(44)
Published: July 6, 2024
Abstract
Sonodynamic
therapy
(SDT),
featuring
noninvasive,
deeper
penetration,
low
cost,
and
repeatability,
is
a
promising
approach
for
deep‐seated
tumors.
However,
the
general
or
only
utilization
of
SDT
shows
efficiency
unsatisfactory
treatment
outcomes
due
to
complicated
tumor
microenvironment
(TME)
process.
To
circumvent
issues,
three
feasible
approaches
enhancing
SDT‐based
therapeutic
effects,
including
sonosensitizer
optimization,
strategies
conquering
hypoxia
TME,
combinational
are
summarized,
with
particular
focus
on
combination
other
modalities,
chemodynamic
therapy,
photodynamic
photothermal
chemotherapy,
starvation
gas
immunotherapy.
In
end,
current
challenges
in
tumors
discussed
enhanced
effects
provided.
It
envisioned
that
this
review
will
provide
new
insight
into
strategic
design
high‐efficiency
sonosensitizer‐derived
nanotheranostics,
thereby
augmenting
accelerating
potential
clinical
transformation.
Smart Molecules,
Journal Year:
2024,
Volume and Issue:
2(3)
Published: July 4, 2024
Abstract
Prostate‐specific
membrane
antigen
(PSMA)
is
known
to
be
overexpressed
in
prostate
cancer
(PCa).
The
development
of
precise
and
rapid
imaging
technologies
monitor
PSMA
crucial
for
early
diagnosis
therapy.
Fluorescence
the
second
near‐infrared
window
(NIR‐II)
has
emerged
as
a
powerful
tool
real‐time
tracking
vivo
visualization,
offering
high
sensitivity
resolution.
However,
there
lack
stable,
bright
easy‐to‐implement
NIR‐II
fluorescent
probes
targeting.
Herein,
we
presented
PSMA‐targeting
probe
FC‐PSMA
based
on
π‐conjugated
crossbreeding
dyed
strategy
that
affords
stability,
large
extinction
coefficient,
good
brightness.
As
demonstrated,
displayed
fluorescence
quantum
yield
fetal
bovine
serum
(FBS).
Following
intravenous
injection
FC‐PSMA,
tumor‐to‐normal
ratio
intensity
steadily
increased
over
time,
reaching
peak
at
48
h
(tumor‐to‐leg
=
12.16
±
0.90).
This
advancement
enables
identification
PC
through
imaging,
facilitating
high‐performance
guidance
resection
surgery.
Nanoprobes
with
NIR-II
fluorescence
and
a
large
Stokes
shift
are
highly
desirable
for
high-quality
bioimaging
applications.
However,
designing
fluorescent
nanoprobes
the
desired
photophysical
properties
based
on
small
organic
molecules
remains
significant
challenge.
Herein,
we
report
naphthalimide
(NMI)-based
molecule,
NMI-BF2,
by
further
enhancing
electron
affinity
of
NMI
through
incorporation
boron
difluoride
formazanate.
NMI-BF2
exhibits
sufficient
quantum
yield
(QY)
0.53%,
263
nm,
excellent
photostability.
For
biological
applications,
is
coassembled
fetal
bovine
serum
(FBS)
to
prepare
biocompatible
nanoprobe,
NMI-BF2/FBS,
which
maintains
good
QY
0.21%
photothermal
conversion
efficiency
32.5%.
In
vitro
in
vivo
studies
verified
that
NMI-BF2/FBS
nanoprobe
shows
an
antitumor
therapeutic
effect,
guided
photoacoustic
imaging.
