As Aggregation‐Induced Emission Meets with Noncovalent Conformational Locks: Subtly Regulating NIR‐II Molecules for Multimodal Imaging‐Navigated Synergistic Therapies DOI
Jiangao Li,

Niu Niu,

Deliang Wang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)

Published: Sept. 21, 2024

Abstract Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near‐infrared (NIR‐II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation‐induced emission (AIE) formulation able to boost multiple photophysical properties efficient phototheranostics. The introduction NoCLs skeleton conformation‐locking feature center architecture indeed elevates structural planarity rigidity, which simultaneously promotes capacity bathochromic‐shifts wavelength centered NIR‐II region. Meanwhile, AIE tendency mainly originated from flexibly propeller‐like geometry at ends eventually endows molecule satisfactory intensity aggregates. Consequently, utilizing optimized molecule, unprecedented performance on fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photothermal‐chemo synergistic therapy demonstrated precise tumor diagnosis complete ablation.

Language: Английский

Spacer Twisting Strategy to Realize Ultrabright Near-Infrared II Polymer Nanoparticles for Fluorescence Imaging-Guided Tumor Phototheranostics DOI
Yifan Wu, Han Yu,

Chunbin Li

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(41), P. 28178 - 28188

Published: Oct. 3, 2024

Conjugated polymers are becoming popular near-infrared II (NIR-II) phototheranostic agents (PTAs) due to their numerous advantages, such as high photostability, large molar extinction coefficients, and excellent photothermal properties. However, the strong π-π interactions between chains of conjugated resulted in generally low NIR-II emission quantum yields (QY). Therefore, synthesis with QY is an interesting but challenging task. Herein, we proposed a spacer twisting strategy realize ultrabright polymer nanoparticles for fluorescence imaging-guided tumor phototheranostics. Theoretical calculations indicated that PY-IT has largest dihedral angle largely π-conjugated skeleton spacer, which can effectively inhibit intermolecular stacking, resulting improved 16.5% nanoparticles. In addition, NPs perform imaging treatment tumors. The work presents some valuable guides achieving polymeric PTAs QY.

Language: Английский

Citations

5
Highly efficient NIR-II photothermal conversion from a 2,2′-biquinoline-4,4′-dicarboxylate-based photochromic complex DOI
Ning-Ning Zhang,

Ya-Tong Liu,

Li Li

et al.

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(15), P. 4867 - 4875

Published: Jan. 1, 2024

A novel electron-transfer photochromic complex based on BCA exhibits efficient NIR-II photothermal conversion with a high PCE (84.5%).

Language: Английский

Citations

4
Synchronously Manipulating the D−A Interaction and Planarity in Semiconducting Polymers to Achieve 84.7% Photothermal Conversion Efficiency for NIR‐II Imaging‐Guided Tumor Therapy DOI

Xiankun Hu,

Qian Jia, Qiyu Fang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: July 18, 2024

Abstract Exploiting photothermal agents with second‐near‐infrared (NIR‐II, 1000−1700 nm) emission and a high conversion efficiency (PCE) is an appealing challenging task. Herein, by simultaneously tailoring the D−A interaction planarity in fluorophores, two donor‐acceptor (D−A) −type semiconducting polymers (SPs), T‐BTP B‐BTP, are constructed. Compared T‐BTP, B‐BTP shows increased intramolecular interactions improved molecular planarity, leading to bathochromic‐shift absorption, NIR‐II emission, PCE. Notably, NPs achieve remarkable PCE of 84.7%, which among highest PCEs SPs fluorescence imaging‐guided therapy (PTT). Because these promising features, successfully used vascular imaging cancer therapy. This study provides valuable guidelines for development high‐performance SPs.

Language: Английский

Citations

4
Macrophage membrane enveloped on double-locked nanoplatform with right-side-out orientation to improving precise theranostic for atherosclerosis DOI
Jie Liu,

Zhigui He,

Xian Qin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 800 - 817

Published: Feb. 18, 2025

Language: Английский

Citations

0
High‐Efficiency Organic Semiconducting Small Molecule for Deep‐Tissue Phototheranostics: Single 1064 nm Laser Triggered NIR‐IIb Fluorescence Imaging Guided Type‐I Photodynamic/Photothermal Combination Therapy DOI Open Access
Qi Wang, Jiawei Liu,

Linqiang Yang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Organic semiconducting small molecules that simultaneously possess NIR‐IIb (1500–1700 nm) fluorescence imaging (FLI), hypoxia‐tolerant photodynamic therapy (PDT) as well photothermal (PTT) abilities activated by a single NIR‐II (1000‐1700 light can achieve high‐performance deep‐tissue phototheranostics, but have not gain much attention. Herein, novel organic molecule (DTT) with an absorption maximum at 844 nm and emission 944 in its monomer state is synthesized through delicate molecular design. Surprisingly, the spectrum of DTT extend into region. Subsequently, phototheranostic nanoparticles (DTT NPs) dramatically red‐shifted absorption/emission peak (1029/1128 are skillfully developed based on J ‐aggregation strategy, which show greatly high molar absorptivity Upon 1064 excitation, resolution FLI be achieved whole‐body vessels, cerebral vasculatures, tumors living mice treated NPs. Moreover, NPs also produce type‐I reactive oxygen species hyperthermia under laser irradiation for oxygen‐less‐dependent PDT PTT combination therapy, eventually achieving efficient antitumor effects. This work provides facile strategy designing high‐efficiency phototheranostics.

Language: Английский

Citations

0
A CYP2J2‐Activated Photosensitizer with In Situ Enzyme Anchoring Induces Pyroptosis in Cancer Therapy DOI Open Access
Xiang Xia,

Ran Wang,

Yingqi Hu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Abstract In photodynamic therapy, traditional photosensitizers exhibit limited tumor retention and targeting efficiency, posing significant challenges to achieving precision efficacy. this study, a photosensitizer is developed based on hemicyanine dye, known as Icy‐P, which features cationic structure that naturally targets mitochondria. Icy‐P contains CYP2J2 recognition receptors at its active sites, enabling precise of cells. Positioning ethyl carbamate adjacent the group initiates cascade reaction upon recognition, resulting in formation quinone intermediate, undergoes 1,4‐addition reaction. This facilitates binding an enzyme, leading prolonged time. The vivo residence time within cells ranges between 48 h 7 d. Furthermore, generates reactive oxygen species light exposure, mitochondrial damage, caspase‐1 activation, gasdermin D cleavage. These events ultimately induce pyroptosis, thereby enhancing efficacy cancer therapy.

Language: Английский

Citations

0
Pyrrolopyrrole Cyanine-Based Polymer with Superior Multifunctionality for Boosting Cancer Phototheranostics DOI
Xue Meng, Yingnan Xu, Yuan Zhang

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1431 - 1439

Published: March 19, 2025

Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize series semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g–1 cm–1), excellent performance, bright NIR-II fluorescence, PA imaging signals, making it among the highest-performing in these properties. A tumor-targeting agent was developed by coencapsulating heat shock protein (HSP) inhibitor camouflaging M1 macrophage membranes. The integration enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, synergistic effect mPTT under low-power 808 nm laser irradiation, combined HSP inhibition, resulted significant suppression. This work offers valuable insights designing advanced agents.

Language: Английский

Citations

0
GSH-Triggered Nitric Oxide Release from Polyurethane Nanocarriers for Gas-Photothermal Synergistic Therapy of Bacterial-Infected Wounds DOI

Yuyue Xiong,

Shuai Yang,

Yaodong Di

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Wound bacterial infections pose a significant challenge to global public health. Nitric oxide (NO), an endogenous gaseous molecule, shows great potential in antibacterial therapy. However, efficient NO delivery remains critical challenge. Photothermal therapy (PTT) offers noninvasive and highly localized treatment for infections. Leveraging the advantages of both approaches, this study developed polymer-based nanocarrier achieve synergistic PTT. For first time, amphiphilic polyurethane PEG-PNU-PEG containing dinitrate donors were synthesized, which further self-assembled into polymeric nanomicelles loaded with NIR emitting conjugated polymer. In microenvironment, elevated glutathione (GSH) triggered release. Simultaneously, polymer enabled effective photothermal therapy, promoting release gas Experimental results demonstrated that PTT effectively eradicated bacteria, eliminating 69.93% ± 2.79% S. aureus biofilm, > 4.5-fold improvement compared alone (14.8% 2.92%). The vitro assay showed inhibition rate exceeding 99.0%, while vivo studies on infected skin wounds revealed clearance 95.0% 1.95%. Furthermore, system suppressed inflammatory cytokines, promoted collagen deposition, accelerated regeneration, providing strategy broad-spectrum wound healing.

Language: Английский

Citations

0
Win–Win Integration of Genetically Engineered Cellular Nanovesicles with High‐Absorbing Multimodal Phototheranostic Molecules for Boosted Cancer Photo‐Immunotherapy DOI Open Access
Xue Li, Xinwen Ou, Zeng‐Ming Yang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Photo-immunotherapy is one of the most promising cancer treatment strategies. As immunotherapeutic agents, immune checkpoint blockade antibodies against programmed cell death protein 1 (PD-1) or ligand (PD-L1) exhibit substantial potential, but have to face non-specific distribution and subsequent immune-related adverse events. Meanwhile, high-performance phototheranostic agents concurrently possessing multiple modalities high light-harvesting capacity are really attractive highly desired as touching modules. Herein, a win-win strategy that integrates molecule design targeted module preparation developed construct high-powered photo-immunotherapy systems. Specifically, agent (AOTTIT) displaying typical aggregation-induced fluorescence extending second near-infrared II window, well outstanding reactive oxygen species heat production first obtained via ingenious design. Notably, AOTTIT exhibits record molar extinction coefficient among reported organic multimodal molecules. PD-1 genetically engineered membrane-derived nanovesicles (PD-1/CMNVs) prepared both nanocarriers camouflage nanoparticles, yielding multifunctional photo-immunotherapeutic (CMNPs/PD-1) with tumor-specific active homologous targeting ability. The distinct suppression primary metastatic lung tumors after only once tumor substantiated synergistically strengthened efficiency this strategy.

Language: Английский

Citations

0
Side-Chain Engineering of NIR-II-Emissive Aggregation-Induced Emission Luminogens to Boost Photodynamic and Photothermal Antimicrobial Therapy DOI
Yongcheng Chen, Dan Li, Xiaohui Chen

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

The development of antibiotic resistance has made multidrug-resistant bacterial and fungal infections one the most serious health problems worldwide. Photothermal therapy (PTT) photodynamic (PDT) have received increasing attention in antimicrobial fields due to their precision treatment less susceptibility inducing resistance. In particular, developing second near-infrared (NIR-II, 1000-1700 nm)-emissive semiconducting polymers for phototheranostics is highly desirable but remains challenging lack rational molecular design guidelines. Herein, a precise side-chain engineering strategy based on donor-acceptor (D-A)-type semiconductor developed phototherapy. By subtle regulation flexibility, series NIR-II-emissive polymer aggregation-induced-emission (AIE) luminogens (AIEgens) are constructed. optimal PIDT(He)TBT bearing flexible side chains shows physicochemical properties, including highest mass extinction coefficient, best AIE property, red-shifted absorption/emission spectra, photothermal effects. then encapsulated into nanoparticles endow them with water solubility, excellent photostability, enhanced type-I performance terms fluorescence-guided PDT PTT been demonstrated both vitro vivo. This work brings useful insights designing AIEgens efficient phototheranostics.

Language: Английский

Citations

0