3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges

Pharmaceutical Research, Journal Year: 2018, Volume and Issue: 35(9)

Published: July 11, 2018

Growing demand for customized pharmaceutics and medical devices makes the impact of additive manufacturing increased rapidly in recent years. The 3D printing has become one most revolutionary powerful tool serving as a technology precise individually developed dosage forms, tissue engineering disease modeling. current achievements include multifunctional drug delivery systems with accelerated release characteristic, adjustable personalized implants phantoms corresponding to specific patient anatomy well cell-based materials regenerative medicine. This review summarizes newest challenges field pharmaceutical biomedical research that have been published since 2015. Currently techniques are briefly described while comprehensive analysis extrusion-based methods intensively investigated is provided. issue printlets attributes, i.e. shape size regard forms manufacturing. undeniable benefits highlighted, however critical view resulting from limitations also included. regulatory pointed well.

Language: Английский

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3D bioprinting of tissues and organs for regenerative medicine

Advanced Drug Delivery Reviews, Journal Year: 2018, Volume and Issue: 132, P. 296 - 332

Published: July 1, 2018

Language: Английский

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Nanomaterial‐Enabled Wearable Sensors for Healthcare

Advanced Healthcare Materials, Journal Year: 2017, Volume and Issue: 7(1)

Published: Nov. 30, 2017

Abstract Highly sensitive wearable sensors that can be conformably attached to human skin or integrated with textiles monitor the physiological parameters of body surrounding environment have garnered tremendous interest. Owing large surface area and outstanding material properties, nanomaterials are promising building blocks for sensors. Recent advances in nanomaterial‐enabled including temperature, electrophysiological, strain, tactile, electrochemical, environmental presented this review. Integration multiple multimodal sensing integration other components into systems summarized. Representative applications healthcare, continuous health monitoring, daily sports activity tracking, multifunctional electronic highlighted. Finally, challenges, opportunities, future perspectives field discussed.

Language: Английский

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Recent Advances in Biomaterials for 3D Printing and Tissue Engineering

Journal of Functional Biomaterials, Journal Year: 2018, Volume and Issue: 9(1), P. 22 - 22

Published: March 1, 2018

Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering. The applications of 3D the field regenerative medicine and engineering are limited by variety biomaterials that can be used this technology. Many researchers have developed novel compositions to enable their use methods. advantages fabricating using numerous, including ability create complex geometries, porosities, co-culture multiple cells, incorporate growth factors. In review, recently-developed different tissues discussed. Biomaterials categorized into ceramics, polymers, composites. Due nature methods, most ceramics combined with polymers enhance printability. Polymer-based printed mostly extrusion-based broader range medicine. goal is fabricate functional viable organs and, achieve this, methods need researched.

Language: Английский

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Recent Advances in Bioink Design for 3D Bioprinting of Tissues and Organs

Frontiers in Bioengineering and Biotechnology, Journal Year: 2017, Volume and Issue: 5

Published: April 5, 2017

There is a growing demand for alternative fabrication approaches to develop tissues and organs as conventional techniques are not capable of fabricating constructs with required structural, mechanical biological complexity. 3D bioprinting offers great potential fabricate highly complex precise control structure, mechanics matter (i.e., cells extracellular matrix components). an additive manufacturing approach that utilizes "bioink" devices scaffolds in layer-by-layer manner. allows printing cell suspension into tissue construct or without scaffold support. The most common bioinks cell-laden hydrogels, decellulerized ECM (dECM)-based solutions, suspensions. In this mini review, brief description comparison the methods, including extrusion-based, droplet-based, laser-based bioprinting, particular focus on bioink design requirements presented. We also present current state-of-the-art challenges future directions.

Language: Английский

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4D Biofabrication Using Shape‐Morphing Hydrogels

Advanced Materials, Journal Year: 2017, Volume and Issue: 29(46)

Published: Oct. 12, 2017

Abstract Despite the tremendous potential of bioprinting techniques toward fabrication highly complex biological structures and flourishing progress in 3D bioprinting, most critical challenge current approaches is printing hollow tubular structures. In this work, an advanced 4D biofabrication approach, based on shape‐morphing biopolymer hydrogels, developed for self‐folding tubes with unprecedented control over their diameters architectures at high resolution. The versatility approach demonstrated by employing two different biopolymers (alginate hyaluronic acid) mouse bone marrow stromal cells. Harnessing postprinting parameters allows attaining average internal tube as low 20 µm, which not yet achievable other existing bioprinting/biofabrication comparable to smallest blood vessels. proposed process does pose any negative effect viability printed cells, self‐folded hydrogel‐based support cell survival least 7 d without decrease viability. Consequently, presented strategy production dynamically reconfigurable tunable functionality responsiveness, governed selection suitable materials

Language: Английский

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4D printing of polymeric materials for tissue and organ regeneration

Materials Today, Journal Year: 2017, Volume and Issue: 20(10), P. 577 - 591

Published: July 8, 2017

Four dimensional (4D) printing is an emerging technology with great capacity for fabricating complex, stimuli-responsive 3D structures, providing potential tissue and organ engineering applications. Although the 4D concept was first highlighted in 2013, extensive research has rapidly developed, along more-in-depth understanding assertions regarding definition of 4D. In this review, we begin by establishing criteria printing, followed summary state-of-the-art technological advances field. Both transformation-preprogrammed shape memory polymers are intensively surveyed. Afterwards will explore discuss applications regeneration, such as developing synthetic tissues implantable scaffolds, well future perspectives conclusions.

Language: Английский

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Fundamentals and Applications of Photo-Cross-Linking in Bioprinting

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(19), P. 10662 - 10694

Published: April 17, 2020

This review provides a detailed overview of the rapidly advancing field biofabrication, particularly with regards to use photo-cross-linking (i.e., light-based) techniques. The major emphasis this is on fundamentals and key criteria identified for successful design implementation photo-cross-linked bioinks bioresins in extrusion-based lithography-based bioprinting. general mechanisms associated (e.g., free-radical chain polymerization, thiol–ene, photomediated redox) natural synthetic materials are described inform bioink bioresin design, which includes selection polymers, functional group modifications, photoinitiators, light sources that enable facile cytocompatible photo-cross-linking. Depending material bioprinting technique interest, we describe specific or properties must be achieved ensure optimal printability utility. Finally, examples current state-of-the-art applications light-based vitro tissue models, engineering, regenerative medicine provided further motivate future opportunities within landscape facilitated light.

Language: Английский

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Four-dimensional bioprinting: Current developments and applications in bone tissue engineering

Acta Biomaterialia, Journal Year: 2019, Volume and Issue: 101, P. 26 - 42

Published: Oct. 28, 2019

Four-dimensional (4D) bioprinting, in which the concept of time is integrated with three-dimensional (3D) bioprinting as fourth dimension, has currently emerged next-generation solution tissue engineering it presents possibility constructing complex, functional structures. 4D can be used to fabricate dynamic 3D-patterned biological architectures that will change their shapes under various stimuli by employing stimuli-responsive materials. The transformation and maturation printed cell-laden constructs over are also regarded providing unprecedented potential for bone engineering. shape memory properties structures cater need personalized defect repair procedures promote osteogenic differentiation stem cells. In this review, we introduce application different biomaterials a series strategies based on Furthermore, discuss engineering, well current challenges future perspectives. STATEMENTS OF SIGNIFICANCE: have demonstrated technologies, integrate within traditional 3D technology dimension facilitate fabrications architectures. These could go through or via using strategies. Moreover, summarizing applications field these emerging technologies fulfill unaddressed medical requirements. further discussions about perspectives give us more inspirations widespread biomedical field.

Language: Английский

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Current Biomedical Applications of 3D Printing and Additive Manufacturing

Applied Sciences, Journal Year: 2019, Volume and Issue: 9(8), P. 1713 - 1713

Published: April 25, 2019

Additive manufacturing (AM) has emerged over the past four decades as a cost-effective, on-demand modality for fabrication of geometrically complex objects. The ability to design and print virtually any object shape using diverse array materials, such metals, polymers, ceramics bioinks, allowed adoption this technology biomedical applications in both research clinical settings. Current advancements tissue engineering regeneration, therapeutic delivery, medical device operative management planning ensure that AM will continue play an increasingly important role future healthcare. In review, we outline current common techniques materials.

Language: Английский

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