Frontiers in Bioengineering and Biotechnology,
Journal Year:
2020,
Volume and Issue:
8
Published: May 5, 2020
Intelligent
drug
delivery
systems
based
on
nanotechnology
have
been
widely
developed
and
investigated
in
the
field
of
nanomedicine
since
they
were
able
to
maximize
therapeutic
efficacy
minimize
undesirable
adverse
effects.
Among
a
variety
organic
or
inorganic
nanomaterials
available
fabricate
for
cancer
therapy
diagnosis,
poly(D,L-lactic-co-glycolic
acid)
(PLGA)
has
extensively
employed
due
its
biocompatibility
biodegradability.
In
this
paper,
we
review
recent
status
research
application
PLGA-based
(DDSs)
remotely
triggered
tumor
diagnosis.
We
discuss
targeting
strategies
which
provide
DDSs
with
passive,
active
magnetic
tumor-targeting
abilities.
And
employment
further
discussed,
including
ultrasound-triggered,
photo-triggered,
field-triggered,
radiofrequency-triggered
therapy.
Ultrasound-triggered
involves
high
intensity
focused
ultrasound
(HIFU)
treatment,
ultrasound-triggered
chemotherapeutic
release,
ultrasound-enhanced
efficiency
gene
transfection.
Photo-triggered
photodynamic
(PDT),
photothermal
(PTT),
photo-triggered
release.
Additionally,
also
endows
imaging
properties.
Numerous
studies
cited
our
demonstrate
great
potential
as
effective
theranostic
agent
ACS Nano,
Journal Year:
2019,
Volume and Issue:
13(8), P. 8537 - 8565
Published: Aug. 1, 2019
As
a
mussel-inspired
material,
polydopamine
(PDA),
possesses
many
properties,
such
as
simple
preparation
process,
good
biocompatibility,
strong
adhesive
property,
easy
functionalization,
outstanding
photothermal
conversion
efficiency,
and
quenching
effect.
PDA
has
attracted
increasingly
considerable
attention
because
it
provides
versatile
approach
to
functionalize
material
surfaces
for
obtaining
variety
of
multifunctional
nanomaterials.
In
this
review,
recent
significant
research
developments
including
its
synthesis
polymerization
mechanism,
physicochemical
different
nano/microstructures,
diverse
applications
are
summarized
discussed.
For
the
sections
in
surface
modification
biomedicine,
we
mainly
highlight
achievements
past
few
years
(2016–2019).
The
remaining
challenges
future
perspectives
PDA-based
nanoplatforms
discussed
rationally
at
end.
This
timely
overall
review
should
be
desirable
wide
range
scientists
facilitate
further
development
coating
methods
production
materials.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: March 15, 2021
Effective
healing
of
skin
wounds
is
essential
for
our
survival.
Although
has
strong
regenerative
potential,
dysfunctional
and
disfiguring
scars
can
result
from
aberrant
wound
repair.
Skin
scarring
involves
excessive
deposition
misalignment
ECM
(extracellular
matrix),
increased
cellularity,
chronic
inflammation.
Transforming
growth
factor-β
(TGFβ)
signaling
exerts
pleiotropic
effects
on
by
regulating
cell
proliferation,
migration,
production,
the
immune
response.
blocking
TGFβ
reduce
tissue
fibrosis
scarring,
systemic
inhibition
lead
to
significant
side
inhibit
re-epithelization.
In
this
study,
we
develop
a
dressing
material
based
an
integrated
photo-crosslinking
strategy
microcapsule
platform
with
pulsatile
release
TGF-β
inhibitor
achieve
spatiotemporal
specificity
wounds.
The
enhances
closure
while
effectively
suppressing
scar
formation
in
murine
large
animal
preclinical
models.
Our
study
presents
scarless
Progress in Biomaterials,
Journal Year:
2020,
Volume and Issue:
9(4), P. 153 - 174
Published: Oct. 15, 2020
Abstract
Polymeric
microparticles
(MPs)
are
recognized
as
very
popular
carriers
to
increase
the
bioavailability
and
bio-distribution
of
both
lipophilic
hydrophilic
drugs.
Among
different
kinds
polymers,
poly-(lactic-
co
-glycolic
acid)
(PLGA)
is
one
most
accepted
materials
for
this
purpose,
because
its
biodegradability
(due
presence
ester
linkages
that
degraded
by
hydrolysis
in
aqueous
environments)
safety
(PLGA
a
Food
Drug
Administration
(FDA)-approved
compound).
Moreover,
depends
on
number
glycolide
units
present
structure,
indeed,
lower
glycol
content
results
an
increased
degradation
time
conversely
higher
monomer
unit
decreased
time.
Due
feature,
it
possible
design
fabricate
MPs
with
programmable
time-controlled
drug
release.
Many
approaches
procedures
can
be
used
prepare
MPs.
The
chosen
fabrication
methodology
influences
size,
stability,
entrapment
efficiency,
release
kinetics.
For
example,
drugs
chemotherapeutic
agents
(doxorubicin),
anti-inflammatory
non-steroidal
(indomethacin),
nutraceuticals
(curcumin)
were
successfully
encapsulated
prepared
single
emulsion
technique,
while
water-soluble
compounds,
such
aptamer,
peptides
proteins,
involved
use
double
systems
provide
compartment
prevent
molecular
degradation.
purpose
review
overview
about
preparation
characterization
drug-loaded
PLGA
obtained
single,
microfluidic
techniques,
their
current
applications
pharmaceutical
industry.
Graphic
abstract
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(51)
Published: Sept. 24, 2020
Abstract
Transient
electronics
refers
to
an
emerging
class
of
advanced
technology,
defined
by
ability
chemically
or
physically
dissolve,
disintegrate,
and
degrade
in
actively
passively
controlled
fashions
leave
environmentally
physiologically
harmless
by‐products
environments,
particularly
bio‐fluids
aqueous
solutions.
The
unusual
properties
that
are
opposite
operational
modes
conventional
for
a
nearly
infinite
time
frame
offer
unprecedented
opportunities
research
areas
eco‐friendly
electronics,
temporary
biomedical
implants,
data‐secure
hardware
systems,
others.
This
review
highlights
the
developments
transient
including
materials,
manufacturing
strategies,
electronic
components,
kinetics,
along
with
various
potential
applications.
Regenerative Biomaterials,
Journal Year:
2020,
Volume and Issue:
7(3), P. 233 - 245
Published: May 9, 2020
Abstract
Biomaterials
as
bone
substitutes
are
always
considered
foreign
bodies
that
can
trigger
host
immune
responses.
Traditional
designing
principles
have
been
aimed
at
minimizing
the
reactions
by
fabricating
inert
biomaterials.
However,
clinical
evidence
revealed
those
methods
still
limitations
and
many
of
which
were
only
feasible
in
laboratory.
Currently,
osteoimmunology,
very
pioneering
concept
is
drawing
more
attention—it
does
not
simply
regard
response
an
obstacle
during
healing
but
emphasizes
intimate
relationship
skeletal
system,
includes
diverse
cells,
cytokines,
signaling
pathways.
Properties
biomaterials
like
topography,
wettability,
surface
charge,
release
mediators,
ions
other
bioactive
molecules
impose
effects
on
responses
to
interfere
with
system.
Based
formation
mechanisms,
change
from
evasive
reprogramming.
Here,
we
discuss
osteoimmunomodulatory
new
modification
strategies—adjusting
properties
induce
a
favorable
osteoimmune
environment.
Such
strategies
showed
potential
benefit
development
materials
lay
solid
foundation
for
future
application.
ACS Applied Materials & Interfaces,
Journal Year:
2019,
Volume and Issue:
12(3), P. 3279 - 3300
Published: Dec. 24, 2019
Among
the
different
synthetic
polymers
developed
for
biomedical
applications,
poly(lactic-co-glycolic
acid)
(PLGA)
has
attracted
considerable
attention
because
of
its
excellent
biocompatibility
and
biodegradability.
Nanocomposites
based
on
PLGA
metal-based
nanostructures
(MNSs)
have
been
employed
extensively
as
an
efficient
strategy
to
improve
structural
functional
properties
polymer.
The
MNSs
used
impart
new
PLGA,
such
antimicrobial
labeling.
In
present
review,
strategies
available
fabrication
MNS/PLGA
nanocomposites
their
applications
in
field
will
be
discussed,
beginning
with
a
description
preparation
routes,
activity,
cytotoxicity
concerns
nanocomposites.
these
nanocomposites,
carriers
scaffolds
tissue
regeneration
other
therapies
are
subsequently
reviewed.
addition,
potential
advantages
using
treatment
illnesses
analyzed
vitro
vivo
studies,
support
future
research
field.
