International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130237 - 130237
Published: Feb. 17, 2024
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 22, 2024
Abstract Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis amplify efficacy sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine copper, ultrasound-activated piezo-hot carriers transfer easily copper polydopamine. It boosts reactive oxygen species production piezoelectrics, facilitates interconversion between Cu2 + Cu promote hydroxyl radical generation via -catalyzed reactions. Finally, elevated cause membrane structure loosening DNA damage. Transcriptomics metabolomics analysis reveal that intracellular overload restricts tricarboxylic acid cycle, promoting cuproptosis-like death. Therefore, polyetherketoneketone scaffold engineered designed shows excellent antibacterial performance ultrasound stimulation promotes angiogenesis osteogenesis on-demand vivo.
Language: Английский
Citations
62
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)
Published: June 11, 2024
The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.
Language: Английский
Citations
60
Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(9), P. 3051 - 3076
Published: Jan. 1, 2023
This review offers systematic considerations of material design principles and fabrication techniques for biomimetic skin tissue engineering scaffolds.
Language: Английский
Citations
45
Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 237 - 237
Published: April 2, 2024
Large bone defects are the leading contributor to disability worldwide, affecting approximately 1.71 billion people. Conventional graft treatments show several disadvantages that negatively impact their therapeutic outcomes and limit clinical practice. Therefore, much effort has been made devise new more effective approaches. In this context, tissue engineering (BTE), involving use of biomaterials which able mimic natural architecture bone, emerged as a key strategy for regeneration large defects. However, although different types have developed investigated, date, none them completely fulfill requirements an ideal implantable material. in recent years, field nanotechnology application nanomaterials regenerative medicine gained significant attention from researchers. Nanotechnology revolutionized BTE due possibility generating nanoengineered particles overcome current limitations strategies, including reduced cell proliferation differentiation, inadequate mechanical strength biomaterials, poor production extrinsic factors necessary efficient osteogenesis. review, we report on latest vitro vivo studies BTE, focusing effects nanoparticles properties cells regeneration.
Language: Английский
Citations
29
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154434 - 154434
Published: July 31, 2024
Language: Английский
Citations
28
Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 88 - 88
Published: Feb. 1, 2025
This research paper explores the development of AI-optimized lattice structures for biomechanics scaffold design, aiming to enhance bone implant functionality by utilizing advanced human–AI systems. The primary objective is create that mimic mechanical properties natural and improve bioactivity biocompatibility, adapting patient-specific needs. We employed polylactic acid (PLA), calcium hydroxyapatite (cHAP), reduced graphene oxide (rGO) as base materials, leveraging their synergistic properties. scaffolds were intricately designed using nTopology software (nTop 5.12) fabricated via 3D printing techniques, optimizing biomechanical load-bearing cellular integration. study’s findings highlight a notable enhancement in scaffolds, with Gyroid design demonstrating 20% higher energy-absorption capacity than traditional designs. Thermal chemical analysis revealed 15% increase thermal stability composites, enhancing resilience under physiological conditions. However, identified minor inconsistencies filament diameter during printing, which could affect uniformity. These underscore potential integrating AI-driven material composites revolutionizing orthopedic technologies.
Language: Английский
Citations
2
ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6502 - 6519
Published: Feb. 14, 2025
Functionally graded scaffolds (FGSs) designed for bone tissue regeneration exhibit three-dimensional (3D) constructs with spatially varying pores, mirroring the natural structure, aiming to offer temporary support and a conducive environment cells during in defect sites. While existing research on FGSs has primarily focused altering pore architecture tuning biomechanical properties improved regeneration, limited exploration exists 3D multiscale porosity closely mimic bone. In this study, we fabricated investigated macropores radially longitudinally, along micropores within struts. Utilizing nonsolvent-induced phase separation integrated printing, printed poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) composite both uniform FG geometries. Two HA content variations (10 20 wt %) were employed assess their impact scaffold properties. Rheological analysis of polymer suspensions gauged viscosity shear stress. Thermogravimetric (thermal gravimetric analysis) determined PCL decomposition final scaffold. Morphological properties, including porosity, size, distribution, evaluated using microcomputed tomography (micro-CT), while field-emission scanning electron microscopy imaged surface cross-sectional morphology. Mechanical tests (compression tension) assessed strength. vitro assays MC3T3-E1 preosteoblast measured cell viability alkaline phosphatase enzyme activity 10% 20% content. Results confirmed that achieved levels provided sufficient strength supported effective proliferation. Cell culture results demonstrated promoted osteogenesis slow proliferation, whereas proliferation cells. Overall, structural, compositional, biological characterization indicated provide suitable environments functionally morphology potentially offering favorable response.
Language: Английский
Citations
2
Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)
Published: March 3, 2025
Abstract Bone tissue relies on the intricate interplay between blood vessels and nerve fibers, both are essential for many physiological pathological processes of skeletal system. Blood provide necessary oxygen nutrients to bone tissues, remove metabolic waste. Concomitantly, fibers precede during growth, promote vascularization, influence cells by secreting neurotransmitters stimulate osteogenesis. Despite critical roles components, current biomaterials generally focus enhancing intraosseous vessel repair, while often neglecting contribution nerves. Understanding distribution main functions in is crucial developing effective engineering. This review first explores anatomy highlighting their vital embryonic development, metabolism, repair. It covers innovative regeneration strategies directed at accelerating intrabony neurovascular system over past 10 years. The issues covered included material properties (stiffness, surface topography, pore structures, conductivity, piezoelectricity) acellular biological factors [neurotrophins, peptides, ribonucleic acids (RNAs), inorganic ions, exosomes]. Major challenges encountered neurovascularized materials clinical translation have also been highlighted. Furthermore, discusses future research directions potential developments aimed producing repair that more accurately mimic natural healing tissue. will serve as a valuable reference researchers clinicians novel into practice. By bridging gap experimental practical application, these advancements transform treatment defects significantly improve quality life patients with bone-related conditions.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)
Published: March 11, 2023
Abstract Nanostructured biomaterials that replicate natural bone architecture are expected to facilitate regeneration. Here, nanohydroxyapatite (nHAp) with vinyl surface modification is acquired by silicon‐based coupling agent and photointegrated methacrylic anhydride‐modified gelatin manufacture a chemically integrated 3D‐printed hybrid scaffold (75.6 wt% solid content). This nanostructured procedure significantly increases its storage modulus 19.43‐fold (79.2 kPa) construct more stable mechanical structure. Furthermore, biofunctional hydrogel biomimetic extracellular matrix anchored onto the filament of (HGel‐ g ‐nHAp) polyphenol‐mediated multiple chemical reactions, which contributes initiate early osteogenesis angiogenesis recruiting endogenous stem cells in situ. Significant ectopic mineral deposition also observed subcutaneously implanted nude mice enhancement 25.3‐fold after 30 days. Meanwhile, HGel‐ ‐nHAp realizes substantial reconstruction rabbit cranial defect model, achieving 61.3% breaking load strength 73.1% volume fractions comparison cranium 15 weeks implantation. optical integration strategy modified nHAp provides prospective structural design for regenerative scaffold.
Language: Английский
Citations
30
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 172, P. 16 - 37
Published: Oct. 4, 2023
Bone scaffolds play a crucial role in bone tissue engineering by providing mechanical support for the growth of new while enduring static and fatigue loads. Although polymers possess favourable characteristics such as adjustable degradation rate, tissue-compatible stiffness, ease fabrication, low toxicity, their relatively strength has limited use load-bearing applications. While numerous studies have focused on assessing polymeric scaffolds, little research been conducted properties. The current review presents comprehensive study behaviour scaffolds. failure is discussed impact material properties, topological features, loading conditions, environmental factors are also examined. present provides insight into damage evolution within drawing comparisons to observed natural bone. Additionally, effect polymer microstructure, incorporating reinforcing materials, introduction hydrodynamic/corrosive body fluids life discussed. Understanding these parameters enhancing resistance holds promise expanding application clinical settings structural biomaterials. STATEMENT OF SIGNIFICANCE: Polymers promising advantages engineering, including rates, compatibility with native toxicity. However, hindered prior addressed performance lacking. This explores this gap, addressing characteristics, mechanisms, influence like factors. It examines reinforcement pore architectures, fluids, ingrowth effects behaviour. A significant emphasis placed understanding progression comparing it
Language: Английский
Citations
28