Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
26, P. 413 - 424
Published: March 20, 2023
Bone
bionics
and
structural
engineering
have
sparked
a
broad
interest
in
optimizing
artificial
scaffolds
for
better
bone
regeneration.
However,
the
mechanism
behind
scaffold
pore
morphology-regulated
regeneration
remains
unclear,
making
structure
design
of
repair
challenging.
To
address
this
issue,
we
carefully
assessed
diverse
cell
behaviors
mesenchymal
stem
cells
(BMSCs)
on
β-tricalcium
phosphate
(β-TCP)
with
three
representative
morphologies
(i.e.,
cross
column,
diamond,
gyroid
unit,
respectively).
Among
scaffolds,
BMSCs
β-TCP
diamond
unit
(designated
as
D-scaffold)
demonstrated
enhanced
cytoskeletal
forces,
elongated
nucleus,
faster
mobility,
osteogenic
differentiation
potential
(for
example,
alkaline
phosphatase
expression
level
D-scaffold
were
1.5-2
times
higher
than
other
groups).
RNA-sequencing
analysis
signaling
pathway
intervention
revealed
that
Ras
homolog
gene
family
A
(RhoA)/Rho-associated
kinase-2
(ROCK2)
has
in-depth
participated
morphology-mediated
behaviors,
indicating
an
important
role
mechanical
transduction
scaffold-cell
interactions.
Finally,
femoral
condyle
defect
results
showed
could
effectively
promote
endogenous
regeneration,
which
osteogenesis
rate
was
1.2-1.8
groups.
Overall,
work
provides
insights
into
mechanisms
developing
novel
bioadaptive
designs.
Materials Science and Engineering R Reports,
Journal Year:
2021,
Volume and Issue:
145, P. 100596 - 100596
Published: April 2, 2021
Additive
manufacturing
(AM),
also
known
as
three-dimensional
(3D)
printing,
has
boomed
over
the
last
30
years,
and
its
use
accelerated
during
5
years.
AM
is
a
materials-oriented
technology,
printing
resolution
versus
scalability/speed
trade-off
exists
among
various
types
of
materials,
including
polymers,
metals,
ceramics,
glasses,
composite
materials.
Four-dimensional
(4D)
together
with
versatile
transformation
systems,
drives
researchers
to
achieve
utilize
high
dimensional
AM.
Multiple
perspectives
structural
materials
have
been
raised
illustrated
in
this
review,
multi-material
(MMa-AM),
multi-modulus
(MMo-AM),
multi-scale
(MSc-AM),
multi-system
(MSy-AM),
multi-dimensional
(MD-AM),
multi-function
(MF-AM).
The
rapid
tremendous
development
methods
offers
great
potential
for
applications,
such
aerospace
field,
biomedical
electronic
devices,
nuclear
industry,
flexible
wearable
soft
sensors,
actuators,
robotics,
jewelry
art
decorations,
land
transportation,
underwater
porous
structures.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
31(5)
Published: Oct. 15, 2020
Additive
manufacturing
(AM)
allows
the
fabrication
of
customized
bone
scaffolds
in
terms
shape,
pore
size,
material
type
and
mechanical
properties.
Combined
with
possibility
to
obtain
a
precise
3D
image
defects
using
computed
tomography
or
magnetic
resonance
imaging,
it
is
now
possible
manufacture
implants
for
patient-specific
regeneration.
This
paper
reviews
state-of-the-art
different
materials
AM
techniques
used
3D-printed
field
tissue
engineering.
Their
advantages
drawbacks
are
highlighted.
For
materials,
specific
criteria,
were
extracted
from
literature
study:
biomimetism
native
bone,
properties,
biodegradability,
ability
be
imaged
(implantation
follow-up
period),
histological
performances
sterilization
process.
can
classified
three
major
categories:
extrusion-based,
powder-based
liquid-base.
price,
ease
use
space
requirement
analyzed.
Different
combinations
materials/AM
appear
most
relevant
depending
on
targeted
clinical
applications
site,
presence
constraints,
temporary
permanent
implant).
Finally,
some
barriers
impeding
translation
human
clinics
identified,
notably
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(1)
Published: Oct. 7, 2021
Abstract
Biomaterials
is
an
exciting
and
dynamic
field,
which
uses
a
collection
of
diverse
materials
to
achieve
desired
biological
responses.
While
there
constant
evolution
innovation
in
with
time,
biomaterials
research
has
been
hampered
by
the
relatively
long
development
period
required.
In
recent
years,
driven
need
accelerate
development,
applications
machine
learning
science
progressed
leaps
bounds.
The
combination
high‐throughput
theoretical
predictions
experiments
(HTE)
shifted
traditional
Edisonian
(trial
error)
paradigm
data‐driven
paradigm.
this
review,
each
type
biomaterial
their
key
properties
use
cases
are
systematically
discussed,
followed
how
can
be
applied
design
process.
discussions
classified
according
various
types
used
including
polymers,
metals,
ceramics,
nanomaterials,
implants
using
additive
manufacturing.
Last,
current
gaps
potential
further
aid
discovery
application
also
discussed.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
151, P. 106391 - 106391
Aggregate,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
ABSTRACT
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
trauma,
surgical
resection,
degenerative
diseases,
congenital
malformations
are
major
clinical
challenges.
Bone
tissue
engineering
has
significant
advantages
in
the
treatment
severe
defects.
Vascularized
scaffolds
gradually
attracting
attention
development
because
their
excellent
biomimetic
properties
efficient
efficiency.
Three‐dimensional
(3D)
printing
technology,
which
can
be
used
to
fabricate
structures
at
different
scales
using
a
wide
range
materials,
been
production
vascularized
scaffolds.
This
review
discusses
research
progress
3D
for
Angiogenesis‐osteogenesis
coupling
regeneration
process
is
first
introduced,
followed
by
summary
technologies,
inks,
bioactive
factors
Notably,
this
focuses
on
structural
design
strategies
Finally,
application
medicine,
as
well
challenges
outlooks
future
development,
described.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2019,
Volume and Issue:
102, P. 103517 - 103517
