Frontiers in Bioengineering and Biotechnology,
Journal Year:
2021,
Volume and Issue:
9
Published: Sept. 20, 2021
Wound
healing
is
a
common
physiological
process
which
consists
of
sequence
molecular
and
cellular
events
that
occur
following
the
onset
tissue
lesion
in
order
to
reconstitute
barrier
between
body
external
environment.
The
inherent
properties
hydrogels
allow
damaged
heal
by
supporting
hydrated
environment
has
long
been
explored
wound
management
aid
autolytic
debridement.
However,
chronic
non-healing
wounds
require
added
therapeutic
features
can
be
achieved
incorporation
biomolecules
cells
promote
faster
better
outcomes.
In
recent
decades,
numerous
have
developed
modified
match
time
scale
for
distinct
stages
healing.
This
review
will
discuss
effects
various
types
on
pathophysiology,
as
well
ideal
characteristics
healing,
crosslinking
mechanism,
fabrication
techniques
design
considerations
hydrogel
engineering.
Finally,
several
challenges
related
adopting
future
perspectives
are
discussed.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(12), P. 6376 - 6376
Published: June 15, 2021
Poly(2-hydroxyethyl
methacrylate)
(pHEMA)
as
a
biomaterial
with
excellent
biocompatibility
and
cytocompatibility
elicits
minimal
immunological
response
from
host
tissue
making
it
desirable
for
different
biomedical
applications.
This
article
seeks
to
provide
an
in-depth
overview
of
the
properties
applications
pHEMA
bone
regeneration,
wound
healing,
cancer
therapy
(stimuli
non-stimuli
responsive
systems),
ophthalmic
(contact
lenses
ocular
drug
delivery).
As
this
polymer
has
been
widely
applied
in
applications,
specific
consideration
devoted
field.
Pure
does
not
possess
antimicrobial
site
where
device
is
employed
may
be
susceptible
microbial
infections.
Therefore,
strategies
such
use
silver
nanoparticles,
antibiotics,
agents
can
utilized
protect
against
besides
delivery
were
covered.
With
continuous
research
advancement
science
technology,
outlook
promising
will
most
certainly
more
near
future.
The
aim
review
was
bring
together
state-of-the-art
on
their
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
18, P. 100508 - 100508
Published: Nov. 30, 2022
Poor
wound
healing
after
diabetes
mellitus
remains
a
challenging
problem,
and
its
pathophysiological
mechanisms
have
not
yet
been
fully
elucidated.
Persistent
bleeding,
disturbed
regulation
of
inflammation,
blocked
cell
proliferation,
susceptible
infection
impaired
tissue
remodeling
are
the
main
features
diabetic
healing.
Conventional
dressings,
including
gauze,
films
bandages,
limited
function.
They
generally
act
as
physical
barriers
absorbers
exudates,
which
fail
to
meet
requirements
whol
process.
Wounds
in
patients
typically
heal
slowly
due
hyperglycemia
within
bed.
Once
bacterial
cells
develop
into
biofilms,
wounds
will
exhibit
robust
drug
resistance.
Recently,
application
stimuli-responsive
hydrogels,
also
known
"smart
hydrogels",
for
has
attracted
particular
attention.
The
basic
feature
this
system
is
capacities
change
mechanical
properties,
swelling
ability,
hydrophilicity,
permeability
biologically
active
molecules,
etc.,
response
various
stimuli,
temperature,
potential
hydrogen
(pH),
protease
other
biological
factors.
Smart
hydrogels
can
improve
therapeutic
efficacy
limit
total
toxicity
according
characteristics
wounds.
In
review,
we
summarized
mechanism
It
hoped
that
work
provide
some
inspiration
suggestions
research
field.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2021,
Volume and Issue:
9
Published: Sept. 20, 2021
Wound
healing
is
a
common
physiological
process
which
consists
of
sequence
molecular
and
cellular
events
that
occur
following
the
onset
tissue
lesion
in
order
to
reconstitute
barrier
between
body
external
environment.
The
inherent
properties
hydrogels
allow
damaged
heal
by
supporting
hydrated
environment
has
long
been
explored
wound
management
aid
autolytic
debridement.
However,
chronic
non-healing
wounds
require
added
therapeutic
features
can
be
achieved
incorporation
biomolecules
cells
promote
faster
better
outcomes.
In
recent
decades,
numerous
have
developed
modified
match
time
scale
for
distinct
stages
healing.
This
review
will
discuss
effects
various
types
on
pathophysiology,
as
well
ideal
characteristics
healing,
crosslinking
mechanism,
fabrication
techniques
design
considerations
hydrogel
engineering.
Finally,
several
challenges
related
adopting
future
perspectives
are
discussed.
