Mechanism of damage of HIF-1 signaling in chronic diabetic foot ulcers and its related therapeutic perspectives DOI Creative Commons
Dong Mei Zhu, Wuhan Wei, Jingyu Zhang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e24656 - e24656

Published: Jan. 25, 2024

Diabetic foot ulcer (DFU) is a chronic complication of diabetes. Wound healing in patients with DFU generally very slow, high recurrence rate even after the healed. The remains major clinical challenge due to lack understanding its pathogenesis. Given significant impact on patient health and medical costs, enhancing our pathophysiological alterations wound critical. A growing body research has shown that impaired activation HIF-1 pathway diabetics, which weakens mediated responses hypoxia leads down-regulation downstream target genes, leading incurable diabetic ulcers. By analyzing summarizing literature recent years, this review summarizes mechanism signaling damage development DFU, analyzes compares application PHD inhibitors, VHL biomaterials stem cell therapy wounds diabetes, proposes new treatment scheme by participation pathway, provides ideas for DFU.

Language: Английский

Programmed microalgae-gel promotes chronic wound healing in diabetes DOI Creative Commons
Yong Kang, Lingling Xu,

Jinrui Dong

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 3, 2024

Abstract Chronic diabetic wounds are at lifelong risk of developing foot ulcers owing to severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory microenvironment, and the potential for bacterial infection. Here we develop programmed treatment strategy employing live Haematococcus (HEA). By modulating light intensity, HEA can be perform variety functions, such as antibacterial activity, supply, ROS scavenging, immune regulation, suggesting its use in therapy. Under high intensity (658 nm, 0.5 W/cm 2 ), green (GHEA) with efficient photothermal conversion mediate wound surface disinfection. decreasing 0.1 photosynthetic system GHEA continuously produce oxygen, effectively resolving problems hypoxia promoting vascular regeneration. Continuous irradiation induces astaxanthin (AST) accumulation cells, resulting gradual transformation from red hue (RHEA). RHEA scavenges excess ROS, enhances expression intracellular antioxidant enzymes, directs polarization M2 macrophages by secreting AST vesicles via exosomes. The living hydrogel sterilize enhance cell proliferation migration promote neoangiogenesis, which could improve infected healing female mice.

Language: Английский

Citations

98
Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing DOI Creative Commons
Yutong Yang, Jiaxin Wang,

Shengfei Huang

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 11(4)

Published: Jan. 29, 2024

ABSTRACT There is still an urgent need to develop hydrogels with intelligent antibacterial ability achieve on-demand treatment of infected wounds and accelerate wound healing by improving the regeneration microenvironment. We proposed a strategy hydrogel dressing bacteria-responsive self-activating property multiple nanozyme activities remodel microenvironment in order significantly promote healing. Specifically, pH-responsive H2O2 self-supplying composite (MSCO) pH/enzyme-sensitive triblock micelles encapsulated lactate oxidase (PPEL) were prepared composed L-arginine-modified chitosan (CA) phenylboronic acid-modified oxidized dextran (ODP) form cascade platform. The respond multifactorial changes bacterial metabolic biofilm eradication through transformation metabolites, chemodynamic therapy enhanced activity conjunction self-driven nitric oxide (NO) release. showed ‘self-diagnostic’ for Through infection stage self-adaptive oxidative stress relief angiogenesis post-infection stage, it promotes closure, accelerates collagen deposition angiogenesis, completely improves regeneration, which provides new method design dressings.

Language: Английский

Citations

96
Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives DOI Creative Commons

Anthony Ko,

Caizhi Liao

BMEMat, Journal Year: 2023, Volume and Issue: 1(3)

Published: June 30, 2023

Abstract Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings three‐dimensional networks hydrophilic polymers absorb retain large amounts water, have been shown to possess excellent biocompatibility, low toxicity, fluid handling properties. In addition, hydrogels create moist wound environment promotes healing by supporting cell proliferation, migration, angiogenesis. Hydrogels, therefore, emerged as promising for promoting DFU healing. this review, we attempt chart the landscape emerging field hydrogel dressing treatment. We will explicitly review assorted preparation methods well detailed discussion various types deployed study. also crystallize key findings, identify remaining challenges, present an outlook on future development enticing field.

Language: Английский

Citations

66
Intelligent biobased hydrogels for diabetic wound healing: A review DOI
Hanzhang Wang, Liming Zhang

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149493 - 149493

Published: Feb. 10, 2024

Language: Английский

Citations

52
A Multifunctional Hydrogel with Photothermal Antibacterial and AntiOxidant Activity for Smart Monitoring and Promotion of Diabetic Wound Healing DOI
Yue Wang, Kun Liu, Wenying Wei

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 21, 2024

Abstract Persistent oxidative stress and bacterial infection are significant challenges that impede diabetic wound healing. By combining diagnosis treatment, pH variation on the tissue can be monitored in real time, precise treatment carried out promptly to promote In this study, a lipoic acid‐modified chitosa (LAMC) hydrogel is constructed via an amidation reaction, ceria oxide‐molybdenum disulfide nanoparticles with polydopamine layer (C@M@P), along carbon quantum dots (CDs) synthesized by hydrothermal method, loaded into hydrogel, thus developing diagnostic therapeutic (LAMC/CD‐C@M@P). incorporating CDs, exhibits high sensitivity reversibility under ultraviolet light. Furthermore, images of hydrogels collected using smartphones converted signals, providing means for early detection infection. Notably, LAMC/CD‐C@M@P excellent photothermal antibacterial capability against Staphylococcus aureus Escherichia coli remarkable antioxidant anti‐inflammatory abilities alleviate reactive oxygen species relieve inflammation response. summary, multifunctional offers great potential as innovative dressing platform, representing advancement chronic management.

Language: Английский

Citations

49
Tannic acid-functionalized 3D porous nanofiber sponge for antibiotic-free wound healing with enhanced hemostasis, antibacterial, and antioxidant properties DOI Creative Commons
Zihang Huang, Donghui Wang, Steffan Møller Sønderskov

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 13, 2023

Developing an antibiotic-free wound dressing with effective hemostasis and antibacterial antioxidant capacity is highly desirable. In this work, a three-dimensional (3D) chitosan/polyvinyl alcohol-tannic acid porous nanofiber sponge (3D-TA) was prepared via electrospinning. Compared two-dimensional (2D) fiber membrane, the unique fluffy 3D-TA had high porosity, water absorption retention ability, hemostatic capacity. Furthermore, 3D functionalized by tannic (TA) endow without loading antibiotics. addition, composite sponges have shown biocompatibility against L929 cells. The in vivo experiment shows enable to accelerate healing. This newly hold great potential as dressings for future clinical application.

Language: Английский

Citations

43
Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound DOI

Weilin Meng,

Ze Lin,

Xuan Cheng

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Feb. 2, 2024

Abstract For various chronic wounds, bacterial infection is one of the important reasons that hinder their healing. Ion‐crosslinked antibacterial hydrogel dressings based on Ag + , Cu 2+ and Zn have made progress in clinical application. However, toxicity released metal ions cannot be ignored. Therefore, how to ensure performance dressing while reducing amount a major challenge for fabrication ion hydrogel. In this study, general method proposed design cationic ion‐crosslinked thiourea groups. Taking formed by mixing modified hyaluronic acid (H‐ANCSN) with (HA‐NCSN/Ag hydrogel) as an example, characteristics application potential kind are thoroughly explored. Due strong chelation groups, HA‐NCSN/Ag can gel at low concentration achieve long‐term slow release stable balance biocompatible properties. Moreover, dynamic thiourea‐Ag crosslinking also endowed property “gelation encapsulation first, injection cover wound when necessary”. Then, mangiferin self‐assembled nanoparticles loaded into radical oxygen species scavenger.

Language: Английский

Citations

34
The Unprecedented Biodegradable Polyzwitterion: A Removal‐Free Patch for Accelerating Infected Diabetic Wound Healing DOI
Zhuoya Wang, Danyang Chen, Hongying Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 12, 2024

Zwitterionic polymers have emerged as an important class of biomaterials to construct wound dressings and antifouling coatings over the past decade due their excellent hydrophilicity. However, all reported zwitterionic are nondegradable because noncleavable carbon─carbon bonding backbones, must be removed periodically after treatment avoid hypoxia in wound, thus leading potential secondary injury. In this work, a biodegradable polyzwitterion patch is fabricated for first time by ring-opening polymerization carboxybetaine dithiolane (CBDS), which self-crosslinked via inter-amide hydrogen bonds dipole-dipole interactions on side chains. The unprecedented polyCBDS (PCBDS) demonstrates enough ductility owing intermolecular physical fully cover irregular wounds, also showing biodegradability performance resulted from existence disulfide groups. Besides, PCBDS degradation-induced released CBDS owns potent antioxidant antibacterial activities. This used diabetic dressing, inhibiting bacterial adhesion external surface, its degradation products can exactly kill bacteria scavenge excessive reactive oxygen species (ROS) at site regulate local microenvironment, including regulation cytokine express macrophage polarization, accelerating infected repair, avoiding

Language: Английский

Citations

27
Stimuli‐Responsive Hydrogels for Antibacterial Applications DOI
Zhe Hao, Xiyan Li, Ruizhong Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Language: Английский

Citations

24
Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries DOI Open Access
Anna Michalicha, Anna Belcarz, Dimitrios A. Giannakoudakis

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 278 - 278

Published: Jan. 5, 2024

Effective wound treatment has become one of the most important challenges for healthcare as it continues to be leading causes death worldwide. Therefore, care technologies significantly evolved in order provide a holistic approach based on various designs functional dressings. Among them, hydrogels have been widely used due their biocompatibility and similarity extracellular matrix. The hydrogel formula offers control an optimal moisture level its ability absorb excess fluid from or release needed. Additionally, can successfully integrated with plethora biologically active components (e.g., nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing performance resulting composite healing applications. In this review, the-state-of-the-art discoveries related stimuli-responsive hydrogel-based dressings summarized, taking into account antimicrobial, anti-inflammatory, antioxidant, hemostatic properties, well other effects re-epithelialization, vascularization, restoration tissue) use.

Language: Английский

Citations

22