The
management
of
diabetic
wounds
faces
significant
challenges
due
to
the
excessive
activation
reactive
oxygen
species
(ROS),
dysregulation
inflammatory
response,
and
impaired
angiogenesis.
A
substantial
body
evidence
suggests
that
aforementioned
diverse
factors
contributing
delayed
healing
may
be
associated
with
autophagy.
Impaired
autophagy
leads
endothelial
fibroblast
dysfunction
impedes
macrophage
phenotypic
transformation.
This
disruption
hinders
angiogenesis
extracellular
matrix
deposition,
ultimately
culminating
in
wound
healing.
Therefore,
biomaterials
possessing
regulatory
functions
hold
potential
for
clinical
applications
enhancing
wounds.
hybrid
multifunctional
hydrogel
(GelMa@SIS-Qu)
has
been
developed,
comprising
methacrylamide
gelatin
(GelMa),
a
small
intestine
submucosal
acellular
(SIS),
quercetin
nanoparticles,
which
demonstrates
capability
promote
promotion
not
only
reduces
ROS
levels
cells
enhances
their
antioxidant
activity
but
also
mitigates
ROS-induced
cell
apoptosis,
thereby
promoting
Furthermore,
facilitates
transformation
macrophages
from
M1
phenotype
M2
phenotype.
study
investigates
distinctive
mechanisms
GelMa@SIS-Qu
proposes
promising
therapeutic
strategy
treating
diabetes-related
Clinical and Translational Medicine,
Journal Year:
2022,
Volume and Issue:
12(11)
Published: Nov. 1, 2022
Abstract
Hydrogels
are
promising
and
widely
utilized
in
the
biomedical
field.
In
recent
years,
anti‐inflammatory
function
of
hydrogel
dressings
has
been
significantly
improved,
addressing
many
clinical
challenges
presented
ongoing
endeavours
to
promote
wound
healing.
Wound
healing
is
a
cascaded
highly
complex
process,
especially
chronic
wounds,
such
as
diabetic
severe
burn
which
adverse
endogenous
or
exogenous
factors
can
interfere
with
inflammatory
regulation,
leading
disruption
process.
Although
insufficient
inflammation
uncommon,
excessive
infiltration
an
almost
universal
feature
impedes
histological
repair
predictable
biological
step
chronological
order.
Therefore,
resolving
essential.
past
5
extensive
research
conducted
on
address
healing,
specifically
by
efficiently
scavenging
free
radicals,
sequestering
chemokines
promoting
M
1
‐to‐M
2
polarization
macrophages,
thereby
regulating
this
study,
we
introduced
novel
demonstrated
innovative
methods
for
their
preparation
application
achieve
enhanced
addition,
summarize
most
important
properties
required
discuss
our
analysis
potential
yet
be
addressed.
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Aug. 22, 2023
The
treatment
of
chronic
and
non-healing
wounds
in
diabetic
patients
remains
a
major
medical
problem.
Recent
reports
have
shown
that
hydrogel
wound
dressings
might
be
an
effective
strategy
for
treating
due
to
their
excellent
hydrophilicity,
good
drug-loading
ability
sustained
drug
release
properties.
As
typical
example,
hyaluronic
acid
dressing
(Healoderm)
has
been
demonstrated
clinical
trials
improve
wound-healing
efficiency
healing
rates
foot
ulcers.
However,
the
degradation
behavior
clinically-used
cannot
adjusted
according
microenvironment.
Due
intricacy
wounds,
antibiotics
other
medications
are
frequently
combined
with
practice,
although
these
easily
hindered
by
hostile
environment.
In
this
case,
scientists
created
responsive-hydrogel
based
on
microenvironment
features
(such
as
high
glucose
low
pH)
or
external
stimuli
light
magnetic
field)
achieve
controllable
release,
gel
degradation,
improvements
order
overcome
issues.
These
anticipated
play
significant
role
therapeutic
dressings.
Here,
we
review
recent
advances
towards
healing,
focus
structure
design,
principle
responsiveness,
degradation.
Last
but
not
least,
advantages
limitations
responsive-hydrogels
applications
will
also
discussed.
We
hope
contribute
furthering
progress
hydrogels
improved
practical
application.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
18, P. 100508 - 100508
Published: Nov. 30, 2022
Poor
wound
healing
after
diabetes
mellitus
remains
a
challenging
problem,
and
its
pathophysiological
mechanisms
have
not
yet
been
fully
elucidated.
Persistent
bleeding,
disturbed
regulation
of
inflammation,
blocked
cell
proliferation,
susceptible
infection
impaired
tissue
remodeling
are
the
main
features
diabetic
healing.
Conventional
dressings,
including
gauze,
films
bandages,
limited
function.
They
generally
act
as
physical
barriers
absorbers
exudates,
which
fail
to
meet
requirements
whol
process.
Wounds
in
patients
typically
heal
slowly
due
hyperglycemia
within
bed.
Once
bacterial
cells
develop
into
biofilms,
wounds
will
exhibit
robust
drug
resistance.
Recently,
application
stimuli-responsive
hydrogels,
also
known
"smart
hydrogels",
for
has
attracted
particular
attention.
The
basic
feature
this
system
is
capacities
change
mechanical
properties,
swelling
ability,
hydrophilicity,
permeability
biologically
active
molecules,
etc.,
response
various
stimuli,
temperature,
potential
hydrogen
(pH),
protease
other
biological
factors.
Smart
hydrogels
can
improve
therapeutic
efficacy
limit
total
toxicity
according
characteristics
wounds.
In
review,
we
summarized
mechanism
It
hoped
that
work
provide
some
inspiration
suggestions
research
field.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 13, 2023
Abstract
The
healing
of
diabetic
wounds
is
hindered
by
various
factors,
including
bacterial
infection,
macrophage
dysfunction,
excess
proinflammatory
cytokines,
high
levels
reactive
oxygen
species,
and
sustained
hypoxia.
These
factors
collectively
impede
cellular
behaviors
the
process.
Consequently,
this
review
presents
intelligent
hydrogels
equipped
with
multifunctional
capacities,
which
enable
them
to
dynamically
respond
microenvironment
accelerate
wound
in
ways,
stimuli
‐responsiveness,
injectable
self‐healing,
shape
‐memory,
conductive
real‐time
monitoring
properties.
relationship
between
multiple
functions
also
discussed.
Based
on
wounds,
antibacterial,
anti‐inflammatory,
immunomodulatory,
antioxidant,
pro‐angiogenic
strategies
are
combined
hydrogels.
application
repair
systematically
discussed,
aiming
provide
guidelines
for
fabricating
exploring
role
therapeutic
processes.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: May 6, 2024
Abstract
Diabetic
foot
ulcers
(DFUs),
a
serious
and
increasingly
common
chronic
issue
among
diabetics,
often
do
not
respond
well
to
generalized
treatment
strategies.
Hypoxia
the
overexpression
of
reactive
oxygen
species
(ROS),
resulting
in
inflammatory
dysregulation
subsequent
imbalance
macrophage
phenotypes,
are
critical
factors
contributing
prolonged
non‐healing
DFU
wounds.
These
two
issues
interact
continuous,
problematic
cycle.
Presently,
there
is
lack
comprehensive
strategies
aimed
at
addressing
both
these
simultaneously
interrupt
this
detrimental
Herein,
an
immunomodulatory
hydrogel
(PHG2)
developed
for
reshaping
hostile
microenvironment.
The
engineered
PHG2
only
removes
excess
internally‐produced
ROS
but
also
generates
O
2
,
with
its
efficiency
further
boosted
by
local
hyperthermia
(42.5
°C)
activated
near‐infrared
light.
Through
vitro
vivo
studies,
along
transcriptomic
assessment,
it
confirmed
that
disrupts
feedback
loop
between
inflammation
while
lowering
M1/M2
ratio.
Such
discoveries
contribute
significant
enhancement
healing
process
injuries
undergo
gradual
increase
movement,
covering
wounds
from
back,
mouth,
foot.
Ultimately,
method
provides
easy,
safe,
highly
effective
solution
treating
DFUs.
Gels,
Journal Year:
2023,
Volume and Issue:
9(2), P. 138 - 138
Published: Feb. 6, 2023
Wound
healing
is
a
long-term
and
complex
biological
process
that
involves
multiple
hemostasis,
inflammation,
proliferation,
remodeling
stages.
In
order
to
realize
comprehensive
systematic
wound
management,
appropriate
treatment
bio-adhesives
are
urgently
needed.
Hydrogel
have
excellent
properties
show
unique
remarkable
advantages
in
the
field
of
management.
This
review
begins
with
detailed
description
design
criteria
functionalities
ideal
hydrogel
for
healing.
Then,
recent
advances
polysaccharide-based
multifunctional
bio-adhesives,
which
involve
chitosan,
hyaluronic
acid,
alginate,
cellulose,
dextran,
konjac
glucomannan,
chondroitin
sulfate,
other
polysaccharides,
comprehensively
discussed.
Finally,
current
challenges
future
research
directions
proposed
stimulate
further
exploration
by
researchers.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(10)
Published: Jan. 1, 2023
Abstract
Diabetic
foot
ulcer
(DFU)
is
one
of
the
most
common
complications
diabetes,
bringing
physical
and
mental
challenges
for
patients
due
to
lack
efficient
curative
therapy.
Despite
considerable
advances
in
pharmacological
surgical
approaches,
clinical
trials
DFU
remain
disappointing
local
overactive
excessive
inflammation.
Immunomodulatory
hydrogels
has
significant
advantages
overcome
challenge
DFUs
Here,
recent
fabrication
regenerative
utilization
functional
altering
immune
microenvironment
are
comprehensively
reviewed.
The
pathological
features
healing
processes
DFUs,
followed
by
summarizing
physicochemical
properties
essential
design
immunomodulation
briefly
introduced.
Then,
potential
immuno‐therapeutic
modalities
emerging
trends
used
treat
via
multitherapeutic
approaches
enhanced
efficacy
safety
discussed.
Taken
together,
linking
structural
their
functions
therapy
with
a
particular
focus
on
immunomodulatory
stimuli,
this
review
can
promote
further
designing
advanced
resulting
improved
diabetic
wound
repair
through
translation
into
setting
near
future.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(21)
Published: April 6, 2023
Diabetic
complications
can
be
ameliorated
by
inhibiting
excessive
oxidative
stress
with
antioxidants.
To
enhance
therapeutic
intervention,
it
is
crucial
to
develop
intelligent
scaffolds
for
efficient
delivery
of
antioxidants
diabetic
wounds.
This
study
introduces
reversible
boronic
bonds
create
an
antioxidant
hydrogel
scaffold.
modifies
gelatin
methacryloyl
(GelMA)
4-carboxyphenyboronic
acid
(CPBA)
synthesize
a
derivative
GelMA
(GelMA-CPBA),
and
then
photo
cross-links
GelMA-CPBA
(−)-epigallocatechin-3-gallate
(EGCG)
form
GelMA-CPBA/EGCG
(GMPE)
hydrogel.
The
GMPE
responds
changes
in
glucose
levels,
more
EGCG
released
as
level
increases
due
the
dissociation
ester
bonds.
shows
good
biocompatibility
biodegradability,
its
mechanical
property
similar
that
skin
tissue.
Both
vitro
vivo
results
demonstrate
effectively
eliminate
reactive
oxygen
species
(ROS),
reduce
inflammation,
promote
angiogenesis,
thereby
improve
collagen
deposition
tissue
remodeling
during
wound
healing.
strategy
offers
new
insight
into
glucose-responsive
scaffolds,
this
responsive
antioxidan
scaffold
holds
great
potential
treatment
chronic
