Advances of medical nanorobots for future cancer treatments

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: July 14, 2023

Early detection and diagnosis of many cancers is very challenging. Late stage a cancer always leads to high mortality rates. It imperative develop novel more sensitive effective therapeutic methods for treatments. The development new treatments has become crucial aspect medical advancements. Nanobots, as one the most promising applications nanomedicines, are at forefront multidisciplinary research. With progress nanotechnology, nanobots enable assembly deployment functional molecular/nanosized machines increasingly being utilized in treatment. In recent years, various practical have transitioned from theory practice, vitro experiments vivo applications. this paper, we review analyze advancements treatments, with particular emphasis on their key fundamental features drug delivery, tumor sensing diagnosis, targeted therapy, minimally invasive surgery, other comprehensive At same time, discuss challenges potential research opportunities revolutionizing future, expected sophisticated capable performing multiple functions tasks, ultimately becoming true nanosubmarines bloodstream.

Language: Английский

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Innovative Robotic Technologies and Artificial Intelligence in Pharmacy and Medicine: Paving the Way for the Future of Health Care—A Review

Big Data and Cognitive Computing, Journal Year: 2023, Volume and Issue: 7(3), P. 147 - 147

Published: Aug. 30, 2023

The future of innovative robotic technologies and artificial intelligence (AI) in pharmacy medicine is promising, with the potential to revolutionize various aspects health care. These advances aim increase efficiency, improve patient outcomes, reduce costs while addressing pressing challenges such as personalized need for more effective therapies. This review examines major robotics AI pharmaceutical medical fields, analyzing advantages, obstacles, implications In addition, prominent organizations research institutions leading way these technological advancements are highlighted, showcasing their pioneering efforts creating utilizing state-of-the-art solutions medicine. By thoroughly current state care exploring possibilities further progress, this work aims provide readers a comprehensive understanding transformative power evolution healthcare sector. Striking balance between embracing technology preserving human touch, investing R&D, establishing regulatory frameworks within ethical guidelines will shape systems. seamless integration systems benefit patients providers.

Language: Английский

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Recent advances in defined hydrogels in organoid research

Bioactive Materials, Journal Year: 2023, Volume and Issue: 28, P. 386 - 401

Published: June 16, 2023

Organoids are in vitro model systems that mimic the complexity of organs with multicellular structures and functions, which provide great potential for biomedical tissue engineering. However, their current formation heavily relies on using complex animal-derived extracellular matrices (ECM), such as Matrigel. These often poorly defined chemical components exhibit limited tunability reproducibility. Recently, biochemical biophysical properties hydrogels can be precisely tuned, offering broader opportunities to support development maturation organoids. In this review, fundamental ECM vivo critical strategies design organoid culture summarized. Two typically derived from natural synthetic polymers applicability improve organoids presented. The representative applications incorporating into highlighted. Finally, some challenges future perspectives also discussed developing advanced technologies toward supporting research.

Language: Английский

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A translational framework to DELIVER nanomedicines to the clinic

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Language: Английский

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Photoinhibiting via simultaneous photoabsorption and free-radical reaction for high-fidelity light-based bioprinting

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 27, 2023

Light-based 3D bioprinting is now employed widely to fabricate geometrically complex constructs for various biomedical applications. However, the inherent light scattering defect creates significant challenges in patterning dilute hydrogels form high-fidelity structures with fine-scale features. Herein, we introduce a photoinhibiting approach that can effectively suppress effect via mechanism of simultaneous photoabsorption and free-radical reaction. This biocompatible significantly improves printing resolution (~1.2 - ~2.1 pixels depending on swelling) shape fidelity (geometric error less than 5%), while minimising costly trial-and-error procedures. The capability using different demonstrated by manufacturing scaffolds featuring intricate multi-sized channels thin-walled networks. Importantly, cellularised gyroid (HepG2) are fabricated successfully, exhibiting high cell proliferation functionality. strategy established this study promotes printability operability light-based systems, allowing numerous new applications tissue engineering.

Language: Английский

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Deployable extrusion bioprinting of compartmental tumoroids with cancer associated fibroblasts for immune cell interactions

Biofabrication, Journal Year: 2023, Volume and Issue: 15(2), P. 025005 - 025005

Published: Jan. 10, 2023

Realizing the translational impacts of three-dimensional (3D) bioprinting for cancer research necessitates innovation in workflows which integrate affordability, user-friendliness, and biological relevance. Herein, we demonstrate 'BioArm', a simple, yet highly effective extrusion platform, can be folded into carry-on pack, rapidly deployed between bio-facilities. BioArm enabled reconstruction compartmental tumoroids with cancer-associated fibroblasts (CAFs), forming shell each tumoroid. The 3D printed core-shell showedde novosynthesized extracellular matrices, enhanced cellular proliferation compared to tumour alone spheroid culture. Further, thein vivophenotypes CAFs normally lost after conventional 2D co-culture re-emerged bioprinted model. Embedding an immune cell-laden collagen matrix permitted tracking interaction cells tumoroids, subsequent simulated immunotherapy treatments. Our deployable workflow could significantly widen accessibility replicating multi-compartmental architectures microenvironment, developing strategies drug testing future.

Language: Английский

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Converging bioprinting and organoids to better recapitulate the tumor microenvironment

Trends in biotechnology, Journal Year: 2023, Volume and Issue: 42(5), P. 648 - 663

Published: Dec. 9, 2023

Bioprinting shows excellent potential for preclinical tumor modeling, with significant advantages over 2D cell cultures in replicating the microenvironment (TME). Recently, use of organoids bioprinting models has emerged as a groundbreaking approach to simulate volumetric tissues. This synergetic fabrication method leverages spatial and geometric control assemble heterogeneous TME components, while maintain collective behaviors. In this review, we provide landscape latest progress on convergence 3D organoids. Furthermore, discuss incorporate organ-on-a-chip improve biomimicry predictability therapeutic performance. Lastly, address challenges personalized medicine predictive clinical integration.

Language: Английский

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3D bioprinting strategy for engineering vascularized tissue models

International Journal of Bioprinting, Journal Year: 2023, Volume and Issue: 9(5), P. 748 - 748

Published: May 9, 2023

Leveraging three-dimensional (3D) bioprinting in the fields of tissue engineering and regenerative medicine has rapidly accelerated progress toward development living constructs biomedical devices. Ongoing vigorous research pursued 3D vitro models to replicate key aspects human physiology by incorporating relevant cell populations adequate environmental cues. Given their advantages being able intimately mimic heterogeneity complexity native counterparts, hold promise as alternatives conventional cultures or animal for translational application model physiology/pathology drug screening. Research highlighted importance models, a sophisticated biomanufacturing strategy is vitally required. In particular, vascularization critical prolonged survival functional maturation engineered tissues, which remained one major challenges establishment physiologically models. To this end, can efficiently generate solid reproducible vascularized with high architectural compositional similarity leading improve structural tissue-specific functionality. Multiple strategies have been developed vascularize tissues spatially controlled patterning vascular precursors generating readily perfusable structures. This review presents an overview advanced development. We present elements rebuilding vasculature 3D-bioprinted discuss recent achievements using bioprinting. Finally, we delineate current future outlooks bioprinting-based

Language: Английский

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3D-printing-assisted synthesis of paclitaxel-loaded niosomes functionalized by cross-linked gelatin/alginate composite: Large-scale synthesis and in-vitro anti-cancer evaluation

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124697 - 124697

Published: May 6, 2023

Language: Английский

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Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 19, 2024

Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical and mechanical nature of native tissues are needed for advanced models development disease. Biomedical research has heavily relied on use animal-derived biomaterials, which is now impeding their translational potential convoluting biological insights gleaned from in vitro tissue models. Natural hydrogels have long served as a convenient effective cell culture tool, but advances materials chemistry fabrication techniques present promising new avenues creating xenogenic-free ECM substitutes appropriate organotypic microphysiological systems. However, significant challenges remain synthetic matrices approximate structural sophistication, complexity, dynamic functionality tissues. This review summarizes key properties ECM, discusses recent approaches used to systematically decouple tune these matrices. The importance mechanics, such viscoelasticity plasticity, also discussed, particularly within context organoid engineered Emerging design strategies mimic reviewed, multi-network hydrogels, supramolecular chemistry, assembled monomers.

Language: Английский

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