The Precise Synthesis of Ultradense Bottlebrush Polymers Unearths Unique Trends in Lyotropic Ordering DOI
Timea Kolozsvary,

Phillip Kohl,

Tianyu Li

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 147(1), P. 889 - 897

Published: Dec. 24, 2024

Biomacromolecular networks with multiscale fibrillar structures are characterized by exceptional mechanical properties, making them attractive architectures for synthetic materials. However, there is a dearth of polymeric building blocks capable forming similarly structured networks. Bottlebrush polymers (BBPs) anisotropic graft the potential to mimic and replace biomacromolecules such as tropocollagen fabrication networks; however, longstanding limitation BBPs has been lack rigidity necessary access lyotropic ordering that underpins formation collagenous While correlation between BBP grafting density well established, approaches rigidify increased underdeveloped. To address this gap in capability, we report synthesis novel macroinitiators provide well-defined an unprecedentedly high density. A suite light scattering techniques used correlate macromolecular architecture demonstrate first time poly(norbornene) exhibit long-range result their rodlike character. Specifically, newly reported ultradensely grafted structures, preparable on multigram scale, form hexagonal arrays while conventional do not, despite showing spatial correlations. These results implicate central role entanglement solution phase assembly new fundamental insight broadly relevant performance BBP-derived materials, spanning biomedical research photonic materials thermal management technologies. Furthermore, these liquid crystalline structural template explore untapped bottom-up semiflexible ultimately intended modular route hierarchically biomimetic

Language: Английский

Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances DOI Creative Commons
Mohammad Mizanur Rahman Khan, Md. Mahamudul Hasan Rumon

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 88 - 88

Published: Jan. 23, 2025

There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive

Language: Английский

Citations

2
Octyl succinic anhydride-modified chitosan/oxidized sodium alginate Schiff base hydrogel loaded with terbinafine hydrochloride: pH-responsive, self-repairing, antifungal properties DOI
Chengze Liu,

Yawen Zhong,

Yifei Xiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140431 - 140431

Published: Jan. 28, 2025

Language: Английский

Citations

1
Vascularised organoids: Recent advances and applications in cancer research DOI Creative Commons
Rui Zhou, Dagmar Brislinger, Julia Fuchs

et al.

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

Language: Английский

Citations

1
Ionically-crosslinked carboxymethyl chitosan scaffolds by additive manufacturing for antimicrobial wound dressing applications DOI Creative Commons

Lorenzo García,

Simona Braccini, Elia Pagliarini

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 346, P. 122640 - 122640

Published: Aug. 22, 2024

Chitosan chemical functionalization is a powerful tool to provide novel materials for additive manufacturing strategies. The main aim of this study was the employment computer-aided wet spinning (CAWS) first time design and fabricate carboxymethyl chitosan (CMCS) scaffolds. For purpose, synthesis derivative with high degree O-substitution (1.07) water soluble in large pH range allowed fabrication scaffolds 3D interconnected porous structure. In particular, developed were composed CMCS fibers small diameter (< 60 μm) hollow structure due fast non solvent-induced coagulation. Zn

Language: Английский

Citations

5
Recent Innovations in Interfacial Strategies for DLP 3D Printing Process Optimization DOI
Lei Wu, Yanlin Song

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Three-dimensional (3D) printing, also known as additive manufacturing, is capable of transforming computer-aided designs into intricate structures directly and on demand. This technology has garnered significant attention in recent years. Among the various approaches, digital light processing (DLP) 3D which utilizes polymers or prepolymers ink, emerged leading new technology, driven by high demand across diverse fields such customized production, healthcare, education, art design. DLP printing employs cured slices molding units recognized for its potential to achieve both speed resolution. Recent insights process highlight inherent interface transformations between liquid solid states. review summarizes key aspects process, speed, precision, material diversity optimization, from view interfacial interactions phases are influenced resin formation, curing surfaces source properties. These include those at resin-UV pattern interface, structure-curing surface resin-curing resin-cured structure each contributing unique characteristics printed results. Finally, this addresses current challenges limitations providing valuable future improvements guiding innovations field.

Language: Английский

Citations

5
Selenium Nanozyme-Crosslinked Composite Hydrogel for Promoting Cartilage Regeneration in Osteoarthritis Via an Integrated ‘Outside-In’ and ‘Inside-Out’ Strategy DOI
Wenyan Gao, Shaochun Li, Ya Miao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
AG73-GelMA/AlgMA hydrogels provide a stable microenvironment for the generation of pancreatic progenitor organoids DOI Creative Commons
Jian Wan,

Yang Xu,

T. Y. Qi

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 27, 2025

Patient specific induced pluripotent stem cells (iPSCs) derived β represent an effective means for disease modeling and autologous diabetes cell replacement therapy. In this study, AG73-5%gelatin methacryloyl (GelMA) /2% alginate methacrylate (AlgMA) hydrogel was employed to generate pancreatic progenitor (PP) organoids improve cell-derived (SC-β) differentiation protocol. The laminin-derived homolog AG73, which mimics certain cell‒matrix interactions, facilitates AKT signaling pathway activation promote PDX1+/NKX6.1+ PP organoid formation effectively modulates subsequent epithelial–mesenchymal transition (EMT) in the endocrine lineage. 5%GelMA/2%AlgMA physiological stiffness of pancreas, providing optimal mechanical stress spatial structure differentiation. Syndecan-4 (SDC4)-ITGAV complex plays a pivotal role early stages development by facilitating SOX9+/PDX1+ bipotent PPs. Our findings demonstrate that AG73-GelMA/AlgMA hydrogel-derived SC-β exhibit enhanced insulin secretion accelerated hyperglycemia reversal vivo. This study presents cost-effective, stable, efficient alternative comprehensive 3D culture vitro mitigating uncertainties associated with conventional methods.

Language: Английский

Citations

0
Advances in bioinspired polymer hydrogel systems with biomedical functionalities DOI Creative Commons
Kazuhíko Ishihara

Science and Technology of Advanced Materials, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 3, 2025

The concepts of bioinspiration and biomimetics that seek to elucidate the morphology functions living organisms specific reactions within cells, extraction important elements from these design functional molecules high-performance materials are becoming more widespread. This review summarizes progress in research on hydrogels inspired by stimuli-responsiveness cell functions. For application a self-regulated release system insulin regulate blood glucose levels, various polymer have been designed using bioactive such as enzymes lectins sense concentrations. In addition, fully synthetic glucose-responsive hydrogel, complex having phenylboronic acid groups form reversible bonds with sugars multivalent hydroxyl group has researched. hydrogel can be further developed act an extracellular matrix which cells preferably reside. proliferation differentiation encapsulated controlled changes properties response sugar. Another advantage is safely retrieved adding sugar dissociate hydrogel. These bioinspired serve for development new medical technologies, molecules, regulated culture environmental matrices, applications layered three-dimensional systems create organized tissue structures.

Language: Английский

Citations

0
Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix DOI Creative Commons
Bruno M. F. Ladeira, Maria C. Gomes, Kongchang Wei

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123270 - 123270

Published: March 22, 2025

Recapitulating the biophysical and biochemical complexity of extracellular matrix (ECM) remains a major challenge in tissue engineering. Hydrogels derived from decellularized ECM provide unique opportunity to replicate architecture bioactivity native ECM, however, they exhibit limited long-term stability mechanical integrity. In turn, materials assembled through supramolecular interactions have achieved considerable success replicating dynamic properties ECM. Here, we merge both methodologies by promoting assembly human amniotic membrane (hAM), mediated host-guest between hAM proteins acryloyl-β-cyclodextrin (AcβCD). Photopolymerization cyclodextrins results formation soft hydrogels that tunable stress relaxation strain-stiffening. Disaggregation bulk yields an injectable granular material self-reconstitutes into shape-adaptable hydrogels, supporting cell delivery neovascularization. Additionally, cells encapsulated within sense respond surrounding matrix, as early spreading is favored greater susceptibility applied stress, evidencing proper cell-matrix interplay. Thus, this system shown be promising substitute for repair modelling.

Language: Английский

Citations

0
Dynamic GelMA/DNA Dual‐Network Hydrogels Promote Woven Bone Organoid Formation and Enhance Bone Regeneration DOI Open Access
Mengchun Zhu, Hao Zhang,

Qirong Zhou

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract Bone organoids, in vitro models mimicking native bone structure and function, rely on 3D stem cell culture for self‐organization, differentiation, ECM secretion, biomineralization, ultimately forming mineralized collagen hierarchies. However, their development is often limited by the lack of suitable matrices with optimal mechanical properties sustained growth differentiation. To address this, a dynamic DNA/Gelatin methacryloyl (GelMA) hydrogel (CGDE) developed to recapitulate key biochemical features ECM, providing supportive microenvironment organoid formation. This dual‐network engineered through hydrogen bonding between DNA GelMA, combined GelMA network crosslinking, resulting appropriate strength enhanced viscoelasticity. During 21‐day culture, CGDE facilitates cellular migration promoting woven (WBO) formation via intramembranous ossification. These WBOs exhibit spatiotemporal architectures supporting mineralization tissue remodeling. In vivo studies demonstrate that CGDE‐derived self‐adaptive properties, enabling rapid osseointegration within 4 weeks. work highlights as robust scalable platform development, offering new insights into biology innovative strategies regeneration.

Language: Английский

Citations

0