Ferroptosis in Haematological Malignancies and Associated Therapeutic Nanotechnologies DOI Open Access
Rachel L. Mynott, Habib Ali, Giles Best

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7661 - 7661

Published: April 21, 2023

Haematological malignancies are heterogeneous groups of cancers the bone marrow, blood or lymph nodes, and while therapeutic advances have greatly improved lifespan quality life those afflicted, many these remain incurable. The iron-dependent, lipid oxidation-mediated form cell death, ferroptosis, has emerged as a promising pathway to induce cancer particularly in that resistant traditional apoptosis-inducing therapies. Although findings been published several solid haematological malignancies, major drawbacks ferroptosis-inducing therapies efficient drug delivery toxicities healthy tissue. development tumour-targeting precision medicines, when combined with nanotechnologies, holds potential way which overcome obstacles progress into clinic. Here, we review current state-of-play ferroptosis well encouraging discoveries field nanotechnologies. While research nanotechnologies is limited, its pre-clinical success tumours suggests this very feasible approach treat such multiple myeloma, lymphoma leukaemia.

Language: Английский

Engineered Living Materials for Advanced Diseases Therapy DOI Open Access
Dong Xue, Wei Wu, Pei Pan

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Language: Английский

Citations

52
Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy DOI Creative Commons

Xumeng Wu,

Ziqi Zhou, Kai Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

Citations

27
Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine DOI
Yanhong Su, Bing Liu, Binghan Wang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 14, 2024

Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.

Language: Английский

Citations

19
Understanding sorafenib-induced ferroptosis and resistance mechanisms: Implications for cancer therapy DOI
Qiuhong Li, Kexin Chen, Tianyi Zhang

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 955, P. 175913 - 175913

Published: July 17, 2023

Language: Английский

Citations

32
Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease DOI
Yutong Sui,

Xue Geng,

Ziwei Wang

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 157, P. 155953 - 155953

Published: June 15, 2024

Language: Английский

Citations

13
Lipid-based nanosystems: the next generation of cancer immune therapy DOI Creative Commons
Ziyun Cheng, Seth‐Frerich Fobian, Elena Gurrieri

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: July 19, 2024

Abstract Immunotherapy has become an important part of the oncotherapy arsenal. Its applicability in various cancer types is impressive, as well its use endogenous mechanisms to achieve desired ends. However, off-target or on-target-off-tumor toxicity, limited activity, lack control combination treatments and, especially for solid tumors, low local accumulation, have collectively clinical thereof. These limitations are partially alleviated by delivery systems. Lipid-based nanoparticles (NPs) emerged revolutionary carriers due favorable physicochemical characteristics, with specific applications and strengths particularly useful immunotherapeutic agent delivery. The aim this review highlight challenges faced immunotherapy how lipid-based NPs been, may be further utilized address such challenges. We discuss recent fundamental a range areas provide detailed discussion main obstacles immune checkpoint inhibition therapies, adoptive cellular cytokine therapies. nanosystems could these through either delivery, direct modulation system, targeting immunosuppressive tumor microenvironment. explore advanced emerging liposomal lipid nanoparticle (LNP) systems nucleic acid intrinsic extrinsic stimulus-responsive formulations, biomimetic immunotherapy. Finally, we key relating NP immunotherapies, suggesting future research directions near term realize potential innovative nanosystems, they crucial steppingstone towards necessary enhancement efficacy Graphical abstract

Language: Английский

Citations

13
Ferroptosis-Based Therapeutic Strategies toward Precision Medicine for Cancer DOI

Tianqi Shi,

Xiaofei Chen, Huihui Ti

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(4), P. 2238 - 2263

Published: Feb. 2, 2024

Ferroptosis is a type of iron-dependent programmed cell death characterized by the dysregulation iron metabolism and accumulation lipid peroxides. This nonapoptotic mode implicated in various physiological pathological processes. Recent findings have underscored its potential as an innovative strategy for cancer treatment, particularly against recalcitrant malignancies that are resistant to conventional therapies. article focuses on ferroptosis-based therapeutic strategies precision covering molecular mechanisms ferroptosis, four major types ferroptosis inducers their inhibitory effects diverse carcinomas, detection fluorescent probes, implementation image-guided therapy. These state-of-the-art tactics manifested enhanced selectivity efficacy malignant carcinomas. Given administration therapy still at burgeoning stage, some challenges future perspectives discussed clinical translation into treatment.

Language: Английский

Citations

12
From synergy to resistance: Navigating the complex relationship between sorafenib and ferroptosis in hepatocellular carcinoma DOI Creative Commons
Zijian Wang, Chunyang Zhou, Yiming Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116074 - 116074

Published: Dec. 25, 2023

Hepatocellular carcinoma (HCC) remains a major global health burden, and sorafenib, multi-kinase inhibitor, has shown effectiveness in the treatment of HCC is considered as first-line therapy for advanced HCC. However, response to sorafenib varies among patients, development drug resistance poses prevalent obstacle. Ferroptosis, newly characterized form cell death featured by iron-dependent lipid peroxidation, emerged critical player reaction The induction ferroptosis been augment anticancer benefits sorafenib. it also observed contribute resistance. This review presents comprehensive thorough analysis that elucidates intricate relationship between over recent years, aiming formulate effective therapeutic approaches liver cancer. Based on this exploration, we propose innovative strategies intended overcome via targeted modulation ferroptosis.

Language: Английский

Citations

22
Lipid Nanovesicle Platforms for Hepatocellular Carcinoma Precision Medicine Therapeutics: Progress and Perspectives DOI Creative Commons
Brandon M. Lehrich, Evan R. Delgado

Organogenesis, Journal Year: 2024, Volume and Issue: 20(1)

Published: Feb. 15, 2024

Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related mortality globally. HCC highly heterogenous with diverse etiologies to different driver mutations potentiating unique tumor immune microenvironments. Current therapeutic options, including checkpoint inhibitors and combinations, have achieved limited objective response rates for majority patients. Thus, a precision medicine approach needed tailor specific treatment options molecular subsets Lipid nanovesicle platforms, either liposome- (synthetic) or extracellular vesicle (natural)-derived present are improved drug delivery vehicles which may be modified contain cargos targeting sites, natural affinity liver toxicity. This mini-review provides updates on applications novel lipid nanovesicle-based therapeutics challenges associated translating this subclass from preclinical models clinic.

Language: Английский

Citations

7
Ferroptosis targeting natural compounds as a promising approach for developing potent liver cancer agents DOI Creative Commons
Pratibha Pandey,

Deena Elsori,

Rahul Kumar

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 26, 2024

Liver cancer is the second leading cause of cancer-related death worldwide. However, treatment options, including surgical resection, transplantation, and molecular drug therapies, are limited effectiveness. Recent studies have demonstrated that suppressing ferroptosis might be a pivotal signal for liver initiation, thus providing new way to combat cancer. Ferroptosis distinct form controlled cell differs from conventional routes like apoptosis, necrosis, pyroptosis. It results intracellular iron overload, which raises iron-dependent reactive oxygen species. This, in turn, leads accumulation lipid peroxides further result oxidative damage membranes, disrupt normal functioning, ultimately speed up phenomenon. regulation intricately linked cellular physiological processes, encompassing metabolism, equilibrium between oxygen-free radical reactions peroxidation. This review intends summarize natural compounds targeting offer therapeutic ideas Furthermore, it serves as foundation identifying applying chemical medicines chemicals target treat efficiently.

Language: Английский

Citations

7