DNA-Based Hydrogels for Bone Regeneration: A Promising Tool for Bone Organoids

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101502 - 101502

Published: Jan. 19, 2025

DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These facilitate the formation of spatial structures through bulk hydrogel fabricating, microsphere formatting, 3D printing. Furthermore, microenvironment can be finely tuned by leveraging degradation products, nanostructure, targeting, delivery capabilities inherent materials. In this review, we underscore advantages hydrogels, detailing composition, gelation techniques, structure optimization. We then delineate three critical elements in promotion using hydrogels: (i) osteogenesis driven phosphate ions, plasmids, oligodeoxynucleotides (ODNs) that enhance mineralization promote gene protein expression; (ii) vascularization facilitated tetrahedral DNA nanostructures (TDNs) aptamers, which boosts expression targeted release; (iii) immunomodulation achieved loaded factors, TDNs, bound ions stimulate macrophage polarization exhibit antibacterial properties. With these properties, used construct organoids, providing an innovative tool disease modeling therapeutic applications tissue engineering. Finally, discuss current challenges future prospects, emphasizing potential impacts regenerative medicine.

Language: Английский

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Rational Design of DNA Hydrogels Based on Molecular Dynamics of Polymers

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(7)

Published: Oct. 11, 2023

Abstract In recent years, DNA has emerged as a fascinating building material to engineer hydrogel due its excellent programmability, which gained considerable attention in biomedical applications. Understanding the structure–property relationship and underlying molecular determinants of is essential precisely tailor macroscopic properties at level. this review, rational design principles networks based on dynamics polymers temporal scale, can be engineered via backbone rigidity crosslinking kinetics, are highlighted. By elucidating mechanisms theories, it aimed provide comprehensive overview how tunable kinetics lead desirable hydrogels, including mechanical properties, diffusive permeability, swelling behaviors, dynamic features. Furthermore, also discussed make hydrogels promising candidates for applications, such cell culture, tissue engineering, bio‐sensing, drug delivery.

Language: Английский

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Self-Healing and Freeze-Resistant Boat-Fruited Sterculia Seed Polysaccharide/Silk Fiber Hydrogel for Wearable Strain Sensors

ACS Sustainable Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 11(37), P. 13756 - 13764

Published: Sept. 7, 2023

This study introduces a sustainable bio-based hydrogel crafted from boat-fruited Sterculia seed polysaccharide (BF), silk fiber (SF), calcium chloride (CaCl2), and borax. The inherent hydrophilic groups natural network structure of BF are conducive to the formation with high water content porous structure. SF serves dual role, providing structural support acting as an antifreezing agent. unique this is characterized by reversible dynamic cross-links, including hydrogen, borate ester, Ca2+/–COOH coordination bonds, which endow it excellent self-healing, mechanical, thermoreversible, freeze-resistant properties. successfully adheres various surfaces, skin, provides stable, repeatable electrical signals for monitoring diverse human movements (e.g., elbow wrist movement) subtle facial expressions. Moreover, exhibits stability reusability. Our thus convenient environmentally friendly strategy fabricating self-healing hydrogels promising applications in healthcare or human–computer interactions.

Language: Английский

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Hydrogels: a promising therapeutic platform for inflammatory skin diseases treatment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(33), P. 8007 - 8032

Published: Jan. 1, 2024

Inflammatory skin diseases, such as psoriasis and atopic dermatitis, pose significant health challenges due to their long-lasting nature, potential for serious complications, risks, which requires treatments that are both effective exhibit minimal side effects. Hydrogels offer an innovative solution biocompatibility, tunability, controlled drug delivery capabilities, enhanced treatment adherence minimized effects risk. This review explores the mechanisms guide design of hydrogel therapeutic platforms from multiple perspectives, focusing on components hydrogels, adjustable physical chemical properties, interactions with cells drugs underscore clinical potential. We also examine various agents dermatitis can be integrated into including traditional drugs, novel compounds targeting oxidative stress, small molecule biologics, emerging therapies, offering insights advantages. Additionally, we trial data evaluate effectiveness safety hydrogel-based in managing under complex disease conditions. Lastly, discuss current future opportunities therapeutics treating improving barrier penetration developing multifunctional highlight enhance long-term stability.

Language: Английский

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Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2599 - 2599

Published: Sept. 14, 2024

This article provides insights into hydrogels of the most promising biodegradable natural polymers and their mechanisms degradation, highlighting different possibilities controlling hydrogel degradation rates. Since can be designed as scaffolding materials to mimic physical biochemical properties tissues, these have found widespread application in field tissue engineering controlled release. In same manner, potential water reservoirs, macro- microelement carriers, or matrixes for selective adsorption pollutants make them excellent candidates sustainable soil amendment solutions. Accordingly, this summarizes recent advances fields engineering, release, remediation, emphasizing new opportunities that degradability its tunability offer design applicability hydrogels.

Language: Английский

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Molecular modulation of aggregation-induced luminescence for improving response sensing of DNA hydrogels

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 276, P. 117254 - 117254

Published: Feb. 12, 2025

Language: Английский

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When nanocellulose meets hydrogels: the exciting story of nanocellulose hydrogels taking flight

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(21), P. 8349 - 8384

Published: Jan. 1, 2023

By revealing the intrinsic link between inherent advantages of nanocellulose and hydrogels, we highlight applications hydrogels in medical treatment, electricity, sensor, environmental governance, food, agriculture.

Language: Английский

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Advances in Injectable Hydrogels Based on Diverse Gelation Methods for Biomedical Imaging

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Abstract The injectable hydrogels can deliver the loads directly to predetermined sites and form reservoirs increase enrichment retention of in target areas. preparation injection involve sol–gel transformation hydrogels, which is affected by factors such as temperature, ions, enzymes, light, mechanics (self‐healing property), pH. However, tracing injection, degradation, drug release from based on different ways gelation a major concern. To solve this problem, contrast agents are introduced into enabling be imaged under techniques fluorescence imaging, photoacoustic magnetic resonance radionuclide imaging. This review details methods for causing imageable hydrogels; discusses application containing various imaging techniques, finally explores potential challenges modes gelation.

Language: Английский

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Hydrogel-Based Biosensors for Effective Therapeutics

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 545 - 545

Published: July 4, 2023

Nanotechnology and polymer engineering are navigating toward new developments to control overcome complex problems. In the last few decades, has received researchers’ attention similarly, polymeric network-engineered structures have been vastly studied. Prior therapeutic application, early rapid detection analyses critical. Therefore, developing hydrogel-based sensors manage acute expression of diseases malignancies devise approaches demands advanced nanoengineering. However, nano-therapeutics emerged as an alternative approach tackling strenuous diseases. Similarly, sensing applications for multiple kinds analytes in water-based environments other media gaining wide interest. It also observed that these functional roles can be used a range biomolecules pathogenic proteins. Moreover, hydrogels three-dimensional (3D) network consists hydrophilic natural or synthetic polymers with multidimensional dynamics. The resemblance tissue structure makes them more unique study inquisitively. Preceding studies shown vast spectrum field biotechnology molecular diagnostics. This review explores recent on engineered biosensors their multipurpose diagnostics therapeutics. We latest hydrogel-engineered biosensors, exclusively DNA-based DNA hydrogel-fabricated biosensors.

Language: Английский

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Force‐Triggered Self‐Destructive Hydrogels

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(52)

Published: Sept. 19, 2023

Abstract Self‐destructive polymers (SDPs) are defined as a class of smart that autonomously degrade upon experiencing an external trigger, such chemical cue or optical excitation. Because SDPs release the materials trapped inside network degradation, they have potential applications in drug delivery and analytical sensing. However, no known respond to mechanical forces been reported, it is fundamentally challenging create mechano‐sensitivity general especially so for force levels below those required classical force‐induced bond scission. To address this challenge, development force‐triggered composed DNA crosslinked hydrogels doped with nucleases described here. Externally applied piconewton selectively expose enzymatic cleavage sites within crosslinks, resulting rapid polymer self‐degradation. The synthesis characterization hydrogels, well kinetics hydrolysis, described. As proof‐of‐concept, time‐dependent rheological changes encapsulated nanoparticle demonstrated. Finally, self‐destruction shown be tuned function nuclease concentration, incubation time, thermodynamic stability crosslinkers.

Language: Английский

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