Multifunctional nano MOF drug delivery platform in combination therapy

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 261, P. 115884 - 115884

Published: Oct. 16, 2023

Language: Английский

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A hyaluronic acid modified copper-based metal-organic framework overcomes multidrug resistance via two-way redox dyshomeostasis under hypoxia

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140148 - 140148

Published: Jan. 1, 2025

Language: Английский

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Cascade-Catalyzed Nanogel for Amplifying Starvation Therapy by Nitric Oxide-Mediated Hypoxia Alleviation

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(14), P. 17313 - 17322

Published: March 27, 2024

Glucose oxidase (Gox)-mediated starvation therapy offers a prospective advantage for malignancy treatment by interrupting the glucose supply to neoplastic cells. However, negative charge of Gox surface hinders its enrichment in tumor tissues. Furthermore, Gox-mediated infiltrates large amounts hydrogen peroxide (H2O2) surround normal tissues and exacerbate intracellular hypoxia. In this study, cascade-catalyzed nanogel (A-NE) was developed boost antitumor effects consumption cascade reactive release nitric oxide (NO) relieve First, cross-linking structure A-NE can serve as bioimmobilization Gox, ensuring stability while improving encapsulation efficiency. Then, efficiently inhibited proliferation cells generating H2O2. addition, covalent l-arginine (l-Arg) consumed H2O2 derived from decomposition generate NO, which augmented on metastatic tumors alleviating Eventually, both vivo vitro studies indicated that nanogels remarkably situ growth hindered recurrence, offering an alternative possibility clinical intervention.

Language: Английский

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A double-gain theranostic nanoplatform based on self-supplying H2O2 nanocomposites for synergistic chemodynamic/gas therapy

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 654, P. 774 - 784

Published: Oct. 19, 2023

Language: Английский

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Nitric Oxide‐Based Nanomedicines for Conquering TME Fortress: Say “NO” to Insufficient Tumor Treatment

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(13)

Published: Dec. 21, 2023

Abstract Almost all cancer treatments are significantly limited by the strong tumor microenvironment (TME) fortress formed abnormal vasculature, dense extracellular matrix (ECM), multidrug resistance (MDR) system, and immune “cold” environment. In huge efforts of dismantling TME fortress, nitric oxide (NO)‐based nanomedicines increasingly occupying a central position have already been identified as super “strong polygonal warriors” to dismantle for efficient treatment, benefiting from NO's unique physicochemical properties extremely fascinating biological effects. However, there is paucity systematic review elaborate on progress fundamental mechanism NO‐based in oncology this aspect. Herein, key characteristics potential NO reprogramming delineated highlighted. The evolution donors advantages discussed subsequently. Moreover, latest solid tumors comprehensively reviewed, including normalizing overcoming ECM barrier, reversing MDR, reactivating immunosuppression TME. Lastly, prospects, limitations, future directions manipulation provide new insights into construction more applicable anticancer nanomedicines.

Language: Английский

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Recent advances in nanomedicine for metabolism-targeted cancer therapy

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(18), P. 2442 - 2461

Published: Jan. 1, 2024

Engineering nanomedicine targeting the unique cancer metabolism emerges as a powerful strategy for specific therapy. In this article, recent advances in nanomaterial-mediated regulation of cancer-related important metabolites are highlighted.

Language: Английский

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Charting a Path to Tumor Therapy: Mastery of Luminescent Metal–Organic Frameworks for Precise Spatiotemporal Control

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)

Published: July 11, 2024

Abstract The field of drug delivery has significantly advanced tumor therapy, yet challenges such as the predictability treatment outcomes and real‐time monitoring progression, recurrence or metastasis. Luminescent metal–organic frameworks (L‐MOFs) are a promising solution to overcome these issues. This review offers comprehensive exploration design synthesis L‐MOFs, presenting their crucial optical properties. highlights pivotal role L‐MOFs in enabling precision medicine for driven by performance. Through strategically harnessing light‐manipulated (MOFs), therapeutic precise spatiotemporal control can be achieved. Moreover, this meticulously examines influence photomanipulating MOFs on situ synthesis, introducing catalytic gas therapy. Additionally, gene therapy vectors that utilize light trigger expression responses is also comprehensively explored article, aiming highlight through concludes proposing an artificial intelligence (AI)‐mediated blueprint with pave way innovative approaches manipulation.

Language: Английский

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Focused starvation of tumor cells using glucose oxidase: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136444 - 136444

Published: Oct. 9, 2024

Language: Английский

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Gas immnuo-nanomedicines fight cancers

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117595 - 117595

Published: Oct. 31, 2024

Certain gas molecules, including hydrogen (H

Language: Английский

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Optimizing cancer therapy through metal organic frameworks-based nanozymes

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141409 - 141409

Published: Feb. 1, 2025

Language: Английский

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