Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Language: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868

Published: July 18, 2024

Language: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(19)

Published: Jan. 18, 2024

Abstract Hydrogen sulfide (H 2 S) is being progressively integrated as an emerging inhibitor of the electron transport chain in energy interference‐based tumor therapy. However, metabolic reprogramming cancer cells causes both oxidative phosphorylation (OXPHOS) and glycolysis to occur simultaneously, which contributes ineffective therapeutic effect blocking a single pathway. To achieve complete suppression production, inorganic H S donor ZnS@ZIF‐8@CaP nanoparticle (ZSZC NP) carrying Ca Zn constructed for achieving simultaneous interference OXPHOS glycolysis. The core–shell ZSZC nanoparticles can break down microenvironment. This leads sustained release calcium overload disrupt normal functioning mitochondria by inhibiting expression cytochrome c causing damage mitochondrial membrane potential. Meanwhile, presence 2+ hinders typical process impeding lactate dehydrogenase glyceraldehyde‐3‐phosphate dehydrogenase. synchronous hampers supply cells. Additionally, expedite necrosis vivo inducing cellular acidification calcification. Therefore, this energy‐blocking strategy will completely deplete reserves provide new insights exploring bioenergetic inhibition treatment approach.

Language: Английский

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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

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Nanozyme: a rising star for cancer therapy

Nanoscale, Journal Year: 2023, Volume and Issue: 15(30), P. 12455 - 12463

Published: Jan. 1, 2023

Tumor therapy by nanozymes.

Language: Английский

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Nanozymes‐Mediated Cascade Reaction System for Tumor‐Specific Diagnosis and Targeted Therapy

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

Abstract Cascade reactions are described as efficient and versatile tools, organized catalytic cascades can significantly improve the efficiency of chemical interworking between nanozymes. They have attracted great interest in many fields such chromogenic detection, biosensing, tumor diagnosis, therapy. However, how to selectively kill cells by enzymatic without harming normal cells, well exploring two or more enzyme‐engineered nanoreactors for cascading reactions, remain challenges field targeted specific cancer diagnostics The latest research advances nanozyme‐catalyzed cascade processes diagnosis therapy this article. Here, various sensing strategies summarized, tumor‐specific diagnostics. Targeting mechanisms treatment using nanozymes classified analyzed, “elements” “dimensions” nanozymes, types, designs structure, assembly modes highly active a variety new targeting based on reaction Finally, integrated application systems tumor‐targeted diagnostic is which will lay foundation design rational, efficient, therapeutic modalities future.

Language: Английский

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A multimodal therapy for infected diabetic wounds based on glucose-responsive nanocomposite-integrated microneedles

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(4), P. 1007 - 1021

Published: Jan. 1, 2024

Antibacterial nanocomposite-integrated microneedles were designed for infected diabetic wound therapy. The nanocomposite could be destroyed by high glucose and exerted a powerful synergistic antibacterial effect against bacterial infections.

Language: Английский

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Nanoparticles (NPs)-mediated targeted regulation of redox homeostasis for effective cancer therapy

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(2), P. 291 - 320

Published: March 24, 2024

Language: Английский

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Recent Advances on NIR‐II Light‐Enhanced Chemodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(10)

Published: Nov. 21, 2023

Abstract Chemodynamic therapy (CDT) is a particular oncological therapeutic strategy by generates the highly toxic hydroxyl radical (•OH) from dismutation of endogenous hydrogen peroxide (H 2 O ) via Fenton or Fenton‐like reactions. However, single CDT therapies have been limited unsatisfactory efficacy. Enhanced chemodynamic (ECDT) triggered near‐infrared (NIR) novel modality based on light energy to improve efficiency penetration and imaging capability visible (400–650 nm) traditional NIR‐I region (650–900 light‐amplified restrict prospects for its clinical application. Combined with high penetration/high precision characteristics second (NIR‐II,) nanoplatform, it expected kill deep tumors efficiently while treatment process in real‐time, more notably, NIR‐II radiation wavelengths above 1000 nm can minimize irradiation damage normal tissues. Such ECDT nanoplatforms greatly improved effectiveness demonstrated extraordinary potential applications. Accordingly, various strategies explored past years CDT. In this review, mechanisms used performance NIR‐II‐enhanced are outlined.

Language: Английский

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