Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113580 - 113580
Published: Feb. 28, 2025
Language: Английский
Food Chemistry, Journal Year: 2024, Volume and Issue: 444, P. 138639 - 138639
Published: Feb. 3, 2024
Language: Английский
Citations
7
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152265 - 152265
Published: May 15, 2024
Language: Английский
Citations
6
Medicine Plus, Journal Year: 2024, Volume and Issue: 1(1), P. 100002 - 100002
Published: Jan. 12, 2024
Language: Английский
Citations
5
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)
Published: June 11, 2024
Abstract Calcium overload can lead to tumor cell death. However, because of the powerful calcium channel excretory system within cells, simplistic overloads do not allow for an effective antitumor therapy. Hence, nanoparticles are created with polyethylene glycol (PEG) donor‐modified phosphate (CaP)‐coated, manganese‐doped hollow mesopores Prussian blue (MMPB) encapsulating glucose oxidase (GOx), called GOx@MMPB@CaP‐PEG (GMCP). GMCP a three‐mode enhancement intratumor reactive oxygen species (ROS) levels is designed increase efficiency intracellular in cells enhance its anticancer efficacy. The released exogenous Ca 2+ and production cytotoxic ROS resulting from perfect circulation outbreak generation that Fenton/Fenton‐like reaction consumption glutathione Fe /Fe 3+ Mn /Mn circle, amelioration hypoxia MMPB‐guided GOx‐mediated starvation Photothermal efficacy‐induced heat owing MMPB accelerates above reactions. Furthermore, abundant contribute damage mitochondria, channels efflux inhibited, overload. further increases promotes apoptosis achieve excellent
Language: Английский
Citations
5
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: June 25, 2024
Abstract The poor prognosis of triple‐negative breast cancer (TNBC) results from its high metastasis, whereas inflammation accompanied by excessive reactive oxygen species (ROS) is prone to aggravate tumor metastasis. Although photothermal therapy (PTT) has extremely therapeutic efficiency, the crafty cells allow an increase in expression heat shock proteins (HSPs) limit effect, and PTT‐induced also thought be a potential trigger for Herein, myricetin, iron ions, polyvinylpyrrolidone were utilized develop nanomedicines self‐assembly strategy treatment metastatic TNBC. with marvelous water solubility dispersion can inhibit glucose transporter 1 interfere mitochondrial function block energy supply cells, achieving starvation on TNBC cells. Nanomedicines excellent conversion properties down‐regulating HSPs enhance effect PTT. Interestingly, broad spectrum ROS scavenging ability successfully attenuates as well influences hypoxia‐inducible factors‐1α/3‐phosphoinositide‐dependent protein kinase related pathway through glycometabolism inhibition reduce cell Moreover, have negligible side effects good clinical application prospects, which provides valuable paradigm interference, anti‐inflammation, starvation, synergistic therapy.
Language: Английский
Citations
5
Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4
Published: Jan. 31, 2025
Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
Anxiety is highly prevalent among cancer patients, significantly impacting their prognosis. Current therapies typically lack anxiolytic properties and may even exacerbate anxiety. Here, a gasotransmitter-nanodonors (GND) system presented that exerts dual anti-tumor effects via "tumor-brain axis" strategy. The GND, synthesized by co-embedding Fe2⁺ S2⁻ ions along with glucose oxidase (GOx) within bovine serum albumin (BSA) nanoparticles (FSG@AB), enables the controlled release of gasotransmitter hydrogen sulfide (H₂S) in acidic tumor microenvironment. H₂S GOx synergistically deplete energy sources, resulting robust effects. Meanwhile, generated at site transported through bloodstream to anterior cingulate cortex (ACC) brain, where it modulates neuronal activity. Specifically, ACC, upregulates glutamate transporter 1 (GLT-1), which reduces extracellular levels attenuates hyperactivity glutamatergic neurons, thereby alleviating anxiety-like behavior. This study proposes GND targets both oncological psychiatric dimensions strategy, improved therapeutic outcomes.
Language: Английский
Citations
0
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(41), P. 9798 - 9839
Published: Jan. 1, 2023
Nanomaterial-based cancer therapy faces significant limitations due to the complex nature of tumor microenvironment (TME).
Language: Английский
Citations
11
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)
Published: June 1, 2024
Abstract Despite advancements in breast cancer treatment, bone metastases remain a significant concern for advanced patients. Current theranostics strategies face challenges integrating tumor and formation. Herein, this work develops an activatable targeted nanomedicine AuMnCO@BSA‐N 3 (AMCBN) to enable novel collaborative integration of second near‐infrared (NIR‐II) fluorescence imaging guided precise osteogenic microenvironment remolding. This strategy employs chemical coordination between noble metal complex carbonyl (MnCO), with surface modification azide groups enhance affinity through passive active targeting. The initiated respondent behavior AMCBN by accelerate the degradation coordinated MnCO, resulting rapid release multifunctional agents efficient chemodynamic therapy (CDT)/gas synergistic therapy. Meanwhile, exceptional bone‐binding properties controlled Mn 2+ ions carbon monoxide (CO) microenvironment, thereby facilitating expression osteogenesis‐related proteins establishing synchronous process tumor‐bone repair.
Language: Английский
Citations
4
Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 564 - 578
Published: Oct. 14, 2024
Language: Английский
Citations
4