Recent progress of porphyrin metal-organic frameworks for combined photodynamic therapy and hypoxia-activated chemotherapy DOI
Qiuyun Zhang, Xiaohui Wang, Jiayi Chen

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(93), P. 13641 - 13652

Published: Jan. 1, 2024

Hypoxia limits the phototherapeutic efficacy of porphyrin-based nMOFs; loading with hypoxia-activated drug TPZ enhances combined PDT and chemotherapy effects.

Language: Английский

Nanoparticles as carriers of photosensitizers to improve photodynamic therapy in cancer DOI
Duy Hieu Truong, Thi Thu Phuong Tran, Tuan Hiep Tran

et al.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: 29(3), P. 221 - 235

Published: Feb. 26, 2024

Photodynamic therapy (PDT) has emerged as a promising non invasive therapeutic approach for cancer treatment, offering unique advantages over conventional treatments. The combination of light activation and photosensitizing agents allows targeted localized destruction cells, reducing damage to surrounding healthy tissues. In recent years, the integration nanoparticles with PDT garnered significant attention due their potential enhance outcomes. This review article aims provide comprehensive overview current state-of-the-art in utilizing photodynamic treatment. We summarized various nanoparticle-based approaches, properties, implications optimizing efficacy, discussed challenges prospects field.

Language: Английский

Citations

5
Aggregation-Induced Emission CN-Based Nanoparticles to Alleviate Hypoxic Liver Fibrosis via Triggering HSC Ferroptosis and Enhancing Photodynamic Therapy DOI
Mingxuan Liu, Yuting Cai, Ruojia Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(26), P. 33021 - 33037

Published: June 18, 2024

Hypoxia can lead to liver fibrosis and severely limits the efficacy of photodynamic therapy (PDT). Herein, carbon nitride (CN)-based hybrid nanoparticles (NPs) VPSGCNs@TSI for light-driven water splitting were utilized solve this problem. CNs doped with selenide glucose (Se-glu) enhance their red/NIR region absorption. Then, vitamin A-poly(ethylene glycol) (VA-PEG) fragments aggregation-induced emission (AIE) photosensitizers TSI introduced into Se-glu-doped CN NPs (VPSGCNs) construct NPs. The introduction VA-PEG enhanced targeting activated hepatic stellate cells (HSCs) reduced toxicity ordinary cells. VPSGCN units could trigger generate O2 under 660 nm laser irradiation, improve hypoxic environment site, downregulate HIF-1α expression, activate HSC ferroptosis via HIF-1α/SLC7A11 pathway. In addition, generated also increase reactive oxygen species (ROS) production in a environment, thereby completely reversing hypoxia-triggered PDT resistance effect. combination water-splitting materials showed 1 + > 2 effect increasing levels fibrosis, promoting HSCs caused by hypoxia.

Language: Английский

Citations

5
Research progress of sorafenib drug delivery system in the treatment of hepatocellular carcinoma: An update DOI Open Access

Qiang-qiang Fan,

Huan Tian,

Jiangxue Cheng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117118 - 117118

Published: July 14, 2024

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors in contemporary era, representing a significant global health concern. Early HCC patients have mild symptoms or are asymptomatic, which promotes onset and progression disease. Moreover, advanced insensitive to chemotherapy, making traditional clinical treatment unable block cancer development. Sorafenib (SFB) first-line targeted drug for with anti-angiogenesis anti-tumor cell proliferation effects. However, efficacy SFB constrained by its off-target distribution, rapid metabolism, multi-drug resistance. In recent years, nanoparticles based on variety materials been demonstrated enhance targeting therapeutic against HCC. Concurrently, advent joint delivery systems has furnished crucial empirical evidence reversing This review will summarize application nanotechnology field over past five years. It focus research progress combined multiple modalities treatment.

Language: Английский

Citations

5
Long-wavelength triggered iridium(iii) complex nanoparticles for photodynamic therapy against hypoxic cancer DOI Creative Commons
Sheng-Nan Liu, Ziwei Wang,

Zihan Wu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(73), P. 9938 - 9941

Published: Jan. 1, 2024

Nanoparticles incorporating an Ir( iii ) complex are photosensitisers that generate types I and II reactive oxygen species upon 655 nm laser irradiation achieve photodynamic therapy in hypoxic cancer cells by targeting mitochondria.

Language: Английский

Citations

5
Recent progress of porphyrin metal-organic frameworks for combined photodynamic therapy and hypoxia-activated chemotherapy DOI
Qiuyun Zhang, Xiaohui Wang, Jiayi Chen

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(93), P. 13641 - 13652

Published: Jan. 1, 2024

Hypoxia limits the phototherapeutic efficacy of porphyrin-based nMOFs; loading with hypoxia-activated drug TPZ enhances combined PDT and chemotherapy effects.

Language: Английский

Citations

5