Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Language: Английский
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102359 - 102359
Published: May 29, 2024
Language: Английский
Citations
8
Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100951 - 100951
Published: Aug. 23, 2024
Metal-organic frameworks (MOFs) offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination metal ions and organic ligands. This review systematically examines structural properties principles MOFs, setting stage for application in delivery. It discusses various classes including those based on zirconium, iron, zinc, copper, titanium, aluminum, potassium, magnesium, assessing drug-loading capacities, biocompatibility, controlled release mechanisms. The effectiveness MOFs is illustrated case studies that highlight capabilities enhancing solubility, providing protection against harsh gastrointestinal environment, enabling precise release. addresses potential challenges, particularly toxicity concerns associated with calls further research into biocompatibility interactions biological systems. concludes by emphasizing revolutionizing delivery, highlighting critical need comprehensive harness full clinical applications.
Language: Английский
Citations
8
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(4), P. 2043 - 2049
Published: March 23, 2024
Extracellular vesicles, especially exosomes, have attracted attention in the last few decades as novel cancer biomarkers. Exosomal membrane proteins provide easy-to-reach targets and can be utilized information sources of their parent cells. In this study, a MagLev-based, highly sensitive, versatile biosensor platform for detecting minor differences density suspended objects is proposed exosome detection. The developed utilizes antibody-functionalized microspheres to capture exosomal (ExoMPs) EpCAM, CD81, CD151 markers cancerous non-small cell lung (NSCLC)-derived respectively. Initially, was protein detection quantification by targeting solubilized ExoMPs, dynamic range 1–100 nM, with LoD values 1.324, 0.638, 0.722 nM CD151, were observed, Then, sensor tested using isolates derived from NSCLC line A549 MRC5 healthy fibroblast line. It shown that able detect differentiate biomarkers non-cancerous lines. Overall, innovative, simple, rapid method shows great potential early diagnosis through biomarker
Language: Английский
Citations
7
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 18, 2024
Abstract Chimeric antigen receptor (CAR)-T cell adoptive immunotherapy is a promising cancer treatment that uses genetically engineered T cells to attack tumors. However, this therapy can have some adverse effects. CAR-T cell-derived exosomes are potential alternative may overcome limitations. Exosomes small vesicles released by and carry variety of molecules, including proteins, RNA, DNA. They play an important role in intercellular communication be used deliver therapeutic agents cells. The application could make more clinically controllable effective. cell-free, which means they less likely cause reactions than combination effective way treat either alone. where cannot reach. appropriate both cellular exosomal platforms practicable for cancer. This offer safe cancers.
Language: Английский
Citations
6
ACS Nano, Journal Year: 2024, Volume and Issue: 18(36), P. 24622 - 24649
Published: Aug. 26, 2024
Biobased therapy represents a promising strategy for myocardial repair. However, the limitations of using live cells, including risk immunogenicity allogeneic cells and inconsistent therapeutic efficacy autologous together with low stability, result in an unsatisfactory clinical outcomes. Therefore, cell-free strategies cardiac tissue repair have been proposed as alternative strategies. Cell-free strategies, primarily based on paracrine effects cellular therapy, demonstrated their potential to inhibit apoptosis, reduce inflammation, promote on-site cell migration proliferation, well angiogenesis, after infarction explored preclinically clinically. Among various modalities, bioderived nanoparticles, adeno-associated virus (AAV), extracellular vesicles, membrane-coated exosome-mimetic nanovesicles, emerged due improved biological function effect. The main focus this review is development existing nanoparticles fundamental working mechanisms, challenges opportunities. key processes requirements are summarized first. Various nanoparticle modalities further highlighted, advantages limitations. Finally, we discuss delivery approaches that offer pathways researchers clinicians translate into practice.
Language: Английский
Citations
6
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 201, P. 115054 - 115054
Published: Aug. 15, 2023
Language: Английский
Citations
16
Nano Letters, Journal Year: 2023, Volume and Issue: 24(1), P. 1 - 8
Published: Dec. 20, 2023
Extracellular vesicles and lipoproteins are lipid-based biological nanoparticles that play important roles in (patho)physiology. Recent evidence suggests extracellular can interact to form functional complexes. Such complexes have been observed biofluids from healthy human donors various vitro disease models such as breast cancer hepatitis C infection. Lipoprotein components also part of the biomolecular corona surrounds contributes identity. Potential mechanisms relevance vesicle–lipoprotein remain poorly understood. This Review addresses current knowledge interface while drawing on pre-existing liposome interactions with nanoparticles. There is an urgent need for further research lipoprotein–extracellular vesicle interface, which could return mechanistic, therapeutic, diagnostic findings.
Language: Английский
Citations
15
Journal of Extracellular Vesicles, Journal Year: 2023, Volume and Issue: 12(9)
Published: Sept. 1, 2023
The variable presence of contaminants in extracellular vesicle (EV) samples is one the major contributors to a lack inter-study reproducibility field. Well-known include protein aggregates, RNA-protein complexes and lipoproteins, which resemble EVs shape, size and/or density. On contrary, polysaccharides, such as hyaluronic acid (HA), have been overlooked EV contaminants. Here, it shown that low medium molecular weight HA polymers are unexpectedly retained some extent fractions using two common isolation methods known for high purity: size-exclusion chromatography tangential flow filtration. Although these techniques capable efficient removal non-EV-associated proteins, this not case polymers, partially weight-dependent manner, especially with chromatography. supramolecular structure hydrodynamic likely contribute filtration-based approaches. Conversely, were ultracentrifugation polymer-based precipitation methods, co-isolating other types has broad range immunomodulatory effects, similar those ascribed various sources EVs. Therefore, should be considered future studies avoid potential inaccurate attributions functional effects
Language: Английский
Citations
12
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1306 - 1306
Published: Oct. 7, 2024
Biomimetic nanoparticles (BMNPs) are innovative nanovehicles that replicate the properties of naturally occurring extracellular vesicles, facilitating highly efficient drug delivery across biological barriers to target organs and tissues while ensuring maximal biocompatibility minimal-to-no toxicity. BMNPs can be utilized for therapeutic payloads imparting novel other nanotechnologies based on organic inorganic materials. The application specifically modified membranes coating has potential enhance their efficacy biocompatibility, presenting a promising pathway advancement technologies. This manuscript is grounded in fundamentals biomimetic technologies, offering comprehensive overview analytical perspective preparation functionalization BMNPs, which include cell membrane-coated (CMCNPs), artificial cell-derived vesicles (ACDVs), fully synthetic (fSVs). review examines both "top-down" "bottom-up" approaches nanoparticle preparation, with particular focus techniques such as membrane coating, cargo loading, microfluidic fabrication. Additionally, it addresses technological challenges solutions associated large-scale production clinical related
Language: Английский
Citations
4
Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)
Published: Jan. 3, 2025
Abstract The biomolecular relevance of medium supplements is a key challenge affecting cell culture practice. composition commonly used differs from that physiological environment, the validity conclusions drawn in vitro studies. This article discusses advantages and disadvantages common supplements, including context-dependent considerations for supplement selection to improve relevance, especially nanomedicine extracellular vesicle research.
Language: Английский
Citations
0