Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(21), P. 5504 - 5520
Published: Jan. 1, 2024
A
zwitterionic
granular
hydrogel
with
tunable
porosity
and
microgel
stiffness
is
used
for
cartilage
tissue
engineering.
This
chemically-defined
biomaterial
provides
a
versatile
platform
investigation
optimization
of
scaffold
parameters.
Small,
Journal Year:
2023,
Volume and Issue:
20(5)
Published: Sept. 26, 2023
Abstract
Microbial
infections
based
on
drug‐resistant
pathogenic
organisms
following
surgery
or
trauma
and
uncontrolled
bleeding
are
the
main
causes
of
increased
mortality
from
worldwide.
The
prevalence
pathogens
has
led
to
a
significant
increase
in
medical
costs
poses
great
threat
normal
life
people.
This
is
an
important
issue
field
biomedicine,
emergence
new
antimicrobial
materials
hydrogels
holds
promise
for
solving
this
problem.
Hydrogel
material
with
good
biocompatibility,
water
absorption,
oxygen
permeability,
adhesion,
degradation,
self‐healing,
corrosion
resistance,
controlled
release
drugs
as
well
structural
diversity.
Bacteria‐disturbing
have
applications
direction
surgical
treatment,
wound
dressing,
device
coating,
tissue
engineering.
paper
reviews
classification
hydrogels,
current
status
research,
potential
one
application
analyzes
research
biomedical
five
aspects:
metal‐loaded
drug‐loaded
carbon‐material‐loaded
fixed
activity
biological
provides
outlook
high
activity,
biodegradability,
injectability,
clinical
applicability
future
development
prospects
field.
Gels,
Journal Year:
2024,
Volume and Issue:
10(4), P. 216 - 216
Published: March 22, 2024
Hydrogels,
being
hydrophilic
polymer
networks
capable
of
absorbing
and
retaining
aqueous
fluids,
hold
significant
promise
in
biomedical
applications
owing
to
their
high
water
content,
permeability,
structural
similarity
the
extracellular
matrix.
Recent
chemical
advancements
have
bolstered
versatility,
facilitating
integration
molecules
guiding
cellular
activities
enabling
controlled
activation
under
time
constraints.
However,
conventional
synthetic
hydrogels
suffer
from
inherent
weaknesses
such
as
heterogeneity
network
imperfections,
which
adversely
affect
mechanical
properties,
diffusion
rates,
biological
activity.
In
response
these
challenges,
hybrid
emerged,
aiming
enhance
strength,
drug
release
efficiency,
therapeutic
effectiveness.
These
hydrogels,
featuring
improved
formulations,
are
tailored
for
tissue
regeneration
across
both
soft
hard
tissues.
The
scientific
community
has
increasingly
recognized
versatile
characteristics
particularly
sector.
This
comprehensive
review
delves
into
recent
hydrogel
systems,
covering
diverse
types,
modification
strategies,
nano/microstructures.
discussion
includes
innovative
fabrication
techniques
click
reactions,
3D
printing,
photopatterning
alongside
elucidation
mechanisms
bioactive
molecules.
By
addressing
underscores
envisages
a
promising
future
various
domains
field.
Biofabrication,
Journal Year:
2024,
Volume and Issue:
16(2), P. 025004 - 025004
Published: Jan. 4, 2024
Abstract
Foreign
body
response
(FBR)
is
a
pervasive
problem
for
biomaterials
used
in
tissue
engineering.
Zwitterionic
hydrogels
have
emerged
as
an
effective
solution
to
this
problem,
due
their
ultra-low
fouling
properties,
which
enable
them
effectively
inhibit
FBR
vivo
.
However,
no
versatile
zwitterionic
bioink
that
allows
high
resolution
extrusion
bioprinting
of
implants
has
thus
far
been
reported.
In
work,
we
introduce
simple,
novel
method
producing
microgel
bioink,
using
alginate
methacrylate
(AlgMA)
crosslinker
and
mechanical
fragmentation
fabrication
method.
Photocrosslinked
made
carboxybetaine
acrylamide
(CBAA)
sulfobetaine
(SBMA)
are
mechanically
fragmented
through
meshes
with
aperture
diameters
50
90
µ
m
produce
bioink.
The
bioinks
both
sizes
showed
excellent
rheological
properties
were
high-resolution
printing
objects
overhanging
features
without
requiring
support
structure
or
bath.
AlgMA
dual
role,
allowing
primary
photocrosslinking
the
bulk
hydrogel
well
secondary
ionic
crosslinking
produced
microgels,
quickly
stabilize
printed
construct
calcium
bath
microporous
scaffold.
Scaffolds
∼20%
porosity,
they
supported
viability
chondrogenesis
encapsulated
human
chondrocytes.
Finally,
meniscus
model
was
bioprinted,
demonstrate
bioink’s
versatility
at
large,
cell-laden
constructs
stable
further
vitro
culture
promote
cartilaginous
production.
This
easy
scalable
strategy
direct
cell
encapsulation
scaffold
potential
biocompatibility
nature
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: June 17, 2024
Abstract
Microgels
prepared
from
natural
or
synthetic
hydrogel
materials
have
aroused
extensive
attention
as
multifunctional
cells
drug
carriers,
that
are
promising
for
tissue
engineering
and
regenerative
medicine.
can
also
be
aggregated
into
microporous
scaffolds,
promoting
cell
infiltration
proliferation
repair.
This
review
gives
an
overview
of
recent
developments
in
the
fabrication
techniques
applications
microgels.
A
series
conventional
novel
strategies
including
emulsification,
microfluidic,
lithography,
electrospray,
centrifugation,
gas-shearing,
three-dimensional
bioprinting,
etc.
discussed
depth.
The
characteristics
microgels
microgel-based
scaffolds
culture
delivery
elaborated
with
emphasis
on
advantages
these
carriers
therapy.
Additionally,
we
expound
ongoing
foreseeable
current
limitations
their
aggregate
field
biomedical
engineering.
Through
stimulating
innovative
ideas,
present
paves
new
avenues
expanding
application
techniques.
Biofabrication,
Journal Year:
2025,
Volume and Issue:
17(1), P. 015044 - 015044
Published: Jan. 1, 2025
Tissue-engineered
grafts
that
mimic
articular
cartilage
show
promise
for
treating
injuries.
However,
engineering
cell-based
therapies
to
match
zonal
architecture
and
biochemical
composition
remains
challenging.
Decellularized
extracellular
matrix
(dECM)
has
gained
attention
its
chondro-inductive
properties,
yet
dECM-based
bioinks
have
limitations
in
mechanical
stability
printability.
This
study
proposes
a
rapid
light-based
bioprinting
method
using
tyrosine-based
crosslinking
mechanism,
which
does
not
require
chemical
modifications
of
dECM
thereby
preserves
structure
bioactivity.
Combining
this
resin
with
Filamented
Light
(FLight)
biofabrication
enables
the
creation
cellular,
porous,
anisotropic
scaffolds
composed
aligned
microfilaments.
Specifically,
we
focus
on
effects
various
biopolymer
compositions
(i.e.
hyaluronic
acid,
collagen
I,
dECM)
inner
bulk
light
vs
FLight)
immune
response
cell
morphology,
investigate
their
influence
nascent
ECM
production
long-term
tissue
maturation.
Our
findings
highlight
importance
FLight
directing
deposition
resembling
promoting
construct
maturation,
they
emphasize
superiority
biological-rich
over
single-component
materials
cartilage,
offering
new
avenues
development
effective
strategies.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Abstract
Granular
hydrogel
scaffolds
(GHS),
composed
of
jammed
microparticles
(microgels),
have
emerged
to
overcome
the
structural
limitations
nonporous
(bulk)
hydrogels.
Microscale
void
spaces
among
microgels
in
GHS
promote
cell
infiltration
and
host
tissue
integration;
however,
prevalent
use
spherical
limits
fraction
that
random
close
packing.
To
address
this
persistent
challenge,
a
new
class
gelatin
methacryloyl
(GelMA)
comprising
porous
microgels,
fabricated
via
thermally
induced
polymer
phase
separation
within
composite
is
developed.
These
novel
not
only
attain
hierarchical
porosity
across
inter‐
intramicrogel
length
scales,
but
also
up
≈
170%
increase
compared
with
microgel‐based
counterpart.
Such
while
maintaining
stability,
best
our
knowledge,
highest
reported
literature.
Compared
which
cells
cannot
readily
infiltrate,
vitro
significantly
higher
microgels.
Furthermore,
distribution
more
uniform
made
In
vivo
subcutaneous
implantation
mice
shows
undergo
infiltration.
Up
78%
into
yielded
using
from
This
work
lays
foundation
engineering
GelMA
porosity,
superior
infiltration,
enhanced
integration,
may
open
opportunities
for
developing
next‐generation
granular
biomaterials
accelerating
repair.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(48)
Published: Sept. 28, 2023
Realization
of
interactive
human-machine
interfaces
(iHMI)
is
improved
with
development
soft
tissue-like
strain
sensors
beyond
hard
robotic
exosuits,
potentially
allowing
cognitive
behavior
therapy
and
physical
rehabilitation
for
patients
brain
disorders.
Here,
this
study
reports
on
a
strain-sensitive
granular
adhesive
inspired
by
the
core-shell
architectures
natural
basil
seeds
iHMI
as
well
human-metaverse
interfacing.
The
sensor
consists
easily
fragmented
hydropellets
core
tissue-adhesive
catecholamine
layers
shell,
satisfying
great
on-skin
injectability,
ionic-electrical
conductivity,
sensitive
resistance
changes
through
reversible
yet
robust
cohesion
among
hydropellets.
Particularly,
it
found
that
self-doping
shell
hydrosurfaces
leads
to
compact
ion
density
materials.
Based
these
electrical
properties
sensor,
demonstrated
successful
integration
robot
arm
in
both
real
virtual
environments
enables
control
finger
gesture
haptic
feedback.
This
expresses
benefits
using
hydrogel-based
implementing
writable
bioelectronics
their
bridging
into
metaverse
world.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 8, 2024
Abstract
Skeletal
muscle
injuries
including
volumetric
loss
(VML)
lead
to
excessive
tissue
scarring
and
permanent
functional
disability.
Despite
its
high
prevalence,
there
is
currently
no
effective
treatment
for
VML.
Bioengineering
interventions
such
as
biomaterials
that
fill
the
VML
defect
support
cell
growth
are
a
promising
therapeutic
strategy.
However,
traditional
developed
this
purpose
lack
pore
features
needed
infiltration.
The
present
study
investigates
first
time,
impact
of
granular
hydrogels
on
repair
–
hypothesizing
their
flowability
will
permit
conformable
filling
site
inherent
porosity
invasion
native
myogenic
cells,
leading
repair.
Small
large
microparticle
fragments
prepared
from
photocurable
hyaluronic
acid
polymer
via
extrusion
fragmentation
facile
size
sorting.
In
assembled
hydrogels,
particle
degree
packing
significantly
influence
features,
rheological
behavior,
injectability.
Using
mouse
model
VML,
it
demonstrated
that,
in
contrast
bulk
early‐stage
(satellite
invasion)
late‐stage
(myofiber
regeneration)
processes.
Together,
these
results
highlight
potential
injectable
porous
supporting
endogenous
after
severe
injury.