Antimicrobial Hydrogels: Potential Materials for Medical Application

Small, Journal Year: 2023, Volume and Issue: 20(5)

Published: Sept. 26, 2023

Abstract Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from worldwide. The prevalence pathogens has led to a significant increase in medical costs poses great threat normal life people. This is an important issue field biomedicine, emergence new antimicrobial materials hydrogels holds promise for solving this problem. Hydrogel material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, controlled release drugs as well structural diversity. Bacteria‐disturbing have applications direction surgical treatment, wound dressing, device coating, tissue engineering. paper reviews classification hydrogels, current status research, potential one application analyzes research biomedical five aspects: metal‐loaded drug‐loaded carbon‐material‐loaded fixed activity biological provides outlook high activity, biodegradability, injectability, clinical applicability future development prospects field.

Language: Английский

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Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 216 - 216

Published: March 22, 2024

Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, structural similarity the extracellular matrix. Recent chemical advancements have bolstered versatility, facilitating integration molecules guiding cellular activities enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity network imperfections, which adversely affect mechanical properties, diffusion rates, biological activity. In response these challenges, hybrid emerged, aiming enhance strength, drug release efficiency, therapeutic effectiveness. These hydrogels, featuring improved formulations, are tailored for tissue regeneration across both soft hard tissues. The scientific community has increasingly recognized versatile characteristics particularly sector. This comprehensive review delves into recent hydrogel systems, covering diverse types, modification strategies, nano/microstructures. discussion includes innovative fabrication techniques click reactions, 3D printing, photopatterning alongside elucidation mechanisms bioactive molecules. By addressing underscores envisages a promising future various domains field.

Language: Английский

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Ionically annealed zwitterionic microgels for bioprinting of cartilaginous constructs

Biofabrication, Journal Year: 2024, Volume and Issue: 16(2), P. 025004 - 025004

Published: Jan. 4, 2024

Abstract Foreign body response (FBR) is a pervasive problem for biomaterials used in tissue engineering. Zwitterionic hydrogels have emerged as an effective solution to this problem, due their ultra-low fouling properties, which enable them effectively inhibit FBR vivo . However, no versatile zwitterionic bioink that allows high resolution extrusion bioprinting of implants has thus far been reported. In work, we introduce simple, novel method producing microgel bioink, using alginate methacrylate (AlgMA) crosslinker and mechanical fragmentation fabrication method. Photocrosslinked made carboxybetaine acrylamide (CBAA) sulfobetaine (SBMA) are mechanically fragmented through meshes with aperture diameters 50 90 µ m produce bioink. The bioinks both sizes showed excellent rheological properties were high-resolution printing objects overhanging features without requiring support structure or bath. AlgMA dual role, allowing primary photocrosslinking the bulk hydrogel well secondary ionic crosslinking produced microgels, quickly stabilize printed construct calcium bath microporous scaffold. Scaffolds ∼20% porosity, they supported viability chondrogenesis encapsulated human chondrocytes. Finally, meniscus model was bioprinted, demonstrate bioink’s versatility at large, cell-laden constructs stable further vitro culture promote cartilaginous production. This easy scalable strategy direct cell encapsulation scaffold potential biocompatibility nature

Language: Английский

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Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 17, 2024

Abstract Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells drug carriers, that are promising for tissue engineering and regenerative medicine. can also be aggregated into microporous scaffolds, promoting cell infiltration proliferation repair. This review gives an overview of recent developments in the fabrication techniques applications microgels. A series conventional novel strategies including emulsification, microfluidic, lithography, electrospray, centrifugation, gas-shearing, three-dimensional bioprinting, etc. discussed depth. The characteristics microgels microgel-based scaffolds culture delivery elaborated with emphasis on advantages these carriers therapy. Additionally, we expound ongoing foreseeable current limitations their aggregate field biomedical engineering. Through stimulating innovative ideas, present paves new avenues expanding application techniques.

Language: Английский

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Biofabrication of anisotropic articular cartilage based on decellularized extracellular matrix

Biofabrication, Journal Year: 2025, Volume and Issue: 17(1), P. 015044 - 015044

Published: Jan. 1, 2025

Tissue-engineered grafts that mimic articular cartilage show promise for treating injuries. However, engineering cell-based therapies to match zonal architecture and biochemical composition remains challenging. Decellularized extracellular matrix (dECM) has gained attention its chondro-inductive properties, yet dECM-based bioinks have limitations in mechanical stability printability. This study proposes a rapid light-based bioprinting method using tyrosine-based crosslinking mechanism, which does not require chemical modifications of dECM thereby preserves structure bioactivity. Combining this resin with Filamented Light (FLight) biofabrication enables the creation cellular, porous, anisotropic scaffolds composed aligned microfilaments. Specifically, we focus on effects various biopolymer compositions (i.e. hyaluronic acid, collagen I, dECM) inner bulk light vs FLight) immune response cell morphology, investigate their influence nascent ECM production long-term tissue maturation. Our findings highlight importance FLight directing deposition resembling promoting construct maturation, they emphasize superiority biological-rich over single-component materials cartilage, offering new avenues development effective strategies.

Language: Английский

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Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Granular hydrogel scaffolds (GHS), composed of jammed microparticles (microgels), have emerged to overcome the structural limitations nonporous (bulk) hydrogels. Microscale void spaces among microgels in GHS promote cell infiltration and host tissue integration; however, prevalent use spherical limits fraction that random close packing. To address this persistent challenge, a new class gelatin methacryloyl (GelMA) comprising porous microgels, fabricated via thermally induced polymer phase separation within composite is developed. These novel not only attain hierarchical porosity across inter‐ intramicrogel length scales, but also up ≈ 170% increase compared with microgel‐based counterpart. Such while maintaining stability, best our knowledge, highest reported literature. Compared which cells cannot readily infiltrate, vitro significantly higher microgels. Furthermore, distribution more uniform made In vivo subcutaneous implantation mice shows undergo infiltration. Up 78% into yielded using from This work lays foundation engineering GelMA porosity, superior infiltration, enhanced integration, may open opportunities for developing next‐generation granular biomaterials accelerating repair.

Language: Английский

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Injection‐on‐Skin Granular Adhesive for Interactive Human–Machine Interface

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Sept. 28, 2023

Realization of interactive human-machine interfaces (iHMI) is improved with development soft tissue-like strain sensors beyond hard robotic exosuits, potentially allowing cognitive behavior therapy and physical rehabilitation for patients brain disorders. Here, this study reports on a strain-sensitive granular adhesive inspired by the core-shell architectures natural basil seeds iHMI as well human-metaverse interfacing. The sensor consists easily fragmented hydropellets core tissue-adhesive catecholamine layers shell, satisfying great on-skin injectability, ionic-electrical conductivity, sensitive resistance changes through reversible yet robust cohesion among hydropellets. Particularly, it found that self-doping shell hydrosurfaces leads to compact ion density materials. Based these electrical properties sensor, demonstrated successful integration robot arm in both real virtual environments enables control finger gesture haptic feedback. This expresses benefits using hydrogel-based implementing writable bioelectronics their bridging into metaverse world.

Language: Английский

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Recent advances in zwitterionic polymers-based non-fouling coating strategies for biomedical applications

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102232 - 102232

Published: July 31, 2024

Language: Английский

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Fabrication of reversible bacteria-killing and bacteria-releasing cotton fabrics with anti-bacteria adhesion capacity for potential application in reusable medical materials

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129510 - 129510

Published: Jan. 21, 2024

Language: Английский

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Granular Hydrogels Improve Myogenic Invasion and Repair after Volumetric Muscle Loss

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 8, 2024

Abstract Skeletal muscle injuries including volumetric loss (VML) lead to excessive tissue scarring and permanent functional disability. Despite its high prevalence, there is currently no effective treatment for VML. Bioengineering interventions such as biomaterials that fill the VML defect support cell growth are a promising therapeutic strategy. However, traditional developed this purpose lack pore features needed infiltration. The present study investigates first time, impact of granular hydrogels on repair – hypothesizing their flowability will permit conformable filling site inherent porosity invasion native myogenic cells, leading repair. Small large microparticle fragments prepared from photocurable hyaluronic acid polymer via extrusion fragmentation facile size sorting. In assembled hydrogels, particle degree packing significantly influence features, rheological behavior, injectability. Using mouse model VML, it demonstrated that, in contrast bulk early‐stage (satellite invasion) late‐stage (myofiber regeneration) processes. Together, these results highlight potential injectable porous supporting endogenous after severe injury.

Language: Английский

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