The Unprecedented Biodegradable Polyzwitterion: A Removal‐Free Patch for Accelerating Infected Diabetic Wound Healing

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 12, 2024

Zwitterionic polymers have emerged as an important class of biomaterials to construct wound dressings and antifouling coatings over the past decade due their excellent hydrophilicity. However, all reported zwitterionic are nondegradable because noncleavable carbon─carbon bonding backbones, must be removed periodically after treatment avoid hypoxia in wound, thus leading potential secondary injury. In this work, a biodegradable polyzwitterion patch is fabricated for first time by ring-opening polymerization carboxybetaine dithiolane (CBDS), which self-crosslinked via inter-amide hydrogen bonds dipole-dipole interactions on side chains. The unprecedented polyCBDS (PCBDS) demonstrates enough ductility owing intermolecular physical fully cover irregular wounds, also showing biodegradability performance resulted from existence disulfide groups. Besides, PCBDS degradation-induced released CBDS owns potent antioxidant antibacterial activities. This used diabetic dressing, inhibiting bacterial adhesion external surface, its degradation products can exactly kill bacteria scavenge excessive reactive oxygen species (ROS) at site regulate local microenvironment, including regulation cytokine express macrophage polarization, accelerating infected repair, avoiding

Language: Английский

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Intrinsic antimicrobial resistance: Molecular biomaterials to combat microbial biofilms and bacterial persisters

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122690 - 122690

Published: June 28, 2024

Language: Английский

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Self-absorbing multilayer skin-like composite with Phyllostachys nigra polysaccharides promotes wound healing

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(6)

Published: Nov. 6, 2024

Language: Английский

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Self-healing, injectable chitosan-based hydrogels: Structure, properties and biological applications

Materials Advances, Journal Year: 2024, Volume and Issue: 5(13), P. 5365 - 5393

Published: Jan. 1, 2024

Conventional biomaterials suffer from mechanical stresses and biochemical degradation, compromising performance structural integrity.

Language: Английский

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Double-network hydrogel dressing regulated by cationic polymer-grafted bacterial cellulose for promote rapid healing of infected wounds

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123257 - 123257

Published: Jan. 20, 2025

Language: Английский

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Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154517 - 154517

Published: Aug. 3, 2024

Language: Английский

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Recent advances on thermosensitive hydrogels-mediated precision therapy

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(3), P. 100911 - 100911

Published: April 14, 2024

Precision therapy has become the preferred choice attributed to optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over past few years, sprayable or injectable thermosensitive hydrogels have exhibited high potential. These can be applied as cell-growing scaffolds drug-releasing reservoirs by simply mixing a free-flowing sol phase at room temperature. Inspired their unique properties, been widely delivery treatment platforms for precision medicine. In this review, state-of-the-art developments are investigated, which covers from thermo-gelling mechanisms main components biomedical applications, including wound healing, anti-tumor activity, osteogenesis, periodontal, sinonasal ophthalmic diseases. The most promising applications trends of also discussed light features.

Language: Английский

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Copper selenide nanosheets with photothermal therapy-related properties and multienzyme activity for highly effective eradication of drug resistance

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 666, P. 434 - 446

Published: March 30, 2024

Language: Английский

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Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101113 - 101113

Published: June 1, 2024

Burns represent a prevalent global health concern and are particularly susceptible to bacterial infections. Severe infections may lead serious complications, posing life-threatening risk. Near-infrared (NIR)-assisted photothermal antibacterial combined with antioxidant hydrogel has shown significant potential in the healing of infected wounds. However, existing agents typically metal-based, complicated synthesize, or pose biosafety hazards. In this study, we utilized plant-derived blackcurrant extract (B) as natural source for both properties. By incorporating B into G-O crosslinked through Schiff base reaction between gelatin (G) oxidized pullulan (O), resulting G-

Language: Английский

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Green synthesis-inspired antibacterial, antioxidant and adhesive hydrogels with ultra-fast gelation and hemostasis for promoting infected skin wound healing

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 184, P. 156 - 170

Published: June 17, 2024

Language: Английский

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