Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Abstract
Wound
management
has
always
been
a
challenge
in
the
clinical
treatment
of
diabetes.
In
this
study,
glucose
oxidase
(GOx)
is
grafted
onto
natural
pullulan
polysaccharides,
and
oxidization
carried
out
to
form
self‐healing
hydrogel
using
carboxymethyl
chitosan
by
means
reversible
Schiff
base
covalent
bonding.
The
smart‐response
drug
release
properties
are
demonstrated
diabetic
wounds
taking
advantage
two
key
factors,
namely
pH‐responsive
nature
bonding
fact
that
GOx
reduces
pH
wounds.
To
further
enhance
biological
functions
dressing,
exosomes
(Exos)
introduced
into
system.
present
system
improves
high‐glucose
microenvironment
wounds,
releasing
H
2
O
impart
antimicrobial
effects,
ensuring
realizes
function.
component
used
construct
plays
an
effective
antibacterial
role.
Moreover,
Exos
loaded
effectively
promotes
neovascularization
wound.
also
regulates
macrophage
polarization
levels
persistent
inflammation
These
results
suggest
smart
responsive,
multifunctional,
dressing
ideal
for
