Nano TransMed,
Journal Year:
2024,
Volume and Issue:
3, P. 100030 - 100030
Published: Jan. 6, 2024
Delayed
wound
healing
brings
additional
physical,
mental,
and
financial
burdens.
Microneedles
(MNs)
are
a
novel
dressing
form
can
incorporate
drug
delivery
systems.
Quercetin
is
known
for
its
remarkable
antioxidant
capacity
may
have
distinctive
effect
on
healing.
We
designed
constructed
gelatin
methacryloyl
(GelMa)
MNs
carrying
(Q-MNs).
In
vitro,
the
physical
properties,
cell
safety,
migration,
angiogenesis,
collagen
formation,
oxidative
stress
levels,
were
performed
to
characterize
Q-MNs.
vivo,
full-thickness
skin
models
established
evaluate
re-epithelialization
impact
of
control,
MN,
Q-MN
groups.
The
Q-MNs
mechanically
strong
enough
penetrate
sustained
possessed
good
biocompatibility.
Moreover,
evidently
facilitated
both
in
vitro
promoted
formation
neo-angiogenesis,
reduction
levels.
could
motivate
with
enhanced
vascularization
decreased
thus
providing
feasible
strategy
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(5), P. 2099 - 2126
Published: Jan. 1, 2024
Exosomes,
which
are
small
vesicles
enclosed
by
a
lipid
bilayer
and
released
many
cell
types,
widely
dispersed
have
garnered
increased
attention
in
the
field
of
regenerative
medicine
due
to
their
ability
serve
as
indicators
diseases
agents
with
therapeutic
potential.
Exosomes
play
crucial
role
mediating
intercellular
communication
through
transfer
biomolecules,
including
proteins,
lipids,
RNA,
other
molecular
constituents,
between
cells.
The
targeted
transport
proteins
nucleic
acids
specific
cells
has
potential
enhance
or
impair
biological
functions.
applications,
they
can
be
used
alone
combination
approaches.
examination
unique
attributes
functions
these
factors
emerged
prominent
study
realm
biomedical
research.
This
manuscript
summarizes
origins
properties
exosomes,
structural,
biological,
physical,
chemical
aspects.
paper
offers
complete
recent
progress
tissue
repair
medicine,
emphasizing
possible
implications
methods
forthcoming
regeneration
attempts.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(2), P. 921 - 931
Published: Jan. 30, 2024
Methotrexate
(MTX),
a
primary
treatment
for
moderate
to
severe
psoriasis,
is
limited
in
clinical
use
due
suboptimal
results
and
side
effects
from
subcutaneous
(SC)
injection
oral
administration.
Microneedles
offer
promising
alternative
direct
MTX
delivery
targeted
skin
lesions,
but
issues
such
as
drug
wastage,
dosage
inaccuracy,
residence
time
the
lesions
remain.
This
study
introduces
tip-swellable
microneedle
array
patch
(TSMAP)
using
photo-cross-linked
methacrylated
hyaluronic
acid
(MeHA)
biocompatible
resin
effective
loading
sustained
delivery.
A
two-cast
micromolding
with
vacuum
drying
employed
concentrate
cross-linked
MeHA
about
30%
of
needle's
height
at
tip,
thereby
ensuring
that
only
TSMAP
tip
swells.
Efficient
into
tips
achieved
through
30
s
solution
immersion
10
min
drying,
potentially
minimizing
waste
incomplete
insertion
elasticity.
The
MTX-loaded
effectively
penetrates
both
porcine
psoriasis-like
mouse
its
detaching
substrate
embedding
deeply
tissue,
functioning
release
reservoir.
significantly
prolongs
retention
compared
SC
dissolvable
microneedles.
vivo
demonstrates
TSMAP-mediated
substantially
enhances
therapeutic
outcomes
alleviating
psoriasis
symptoms
downregulating
psoriasis-associated
cytokines,
outperforming
administration,
injection,
Thus,
could
an
efficient
user-friendly
administration
various
diseases.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(4), P. 042008 - 042008
Published: May 20, 2024
Gelatin
methacryloyl
(GelMA)
hydrogels
have
gained
significant
recognition
as
versatile
biomaterials
in
the
biomedical
domain.
GelMA
emulate
vital
characteristics
of
innate
extracellular
matrix
by
integrating
cell-adhering
and
metalloproteinase-responsive
peptide
motifs.
These
features
enable
cellular
proliferation
spreading
within
GelMA-based
hydrogel
scaffolds.
Moreover,
displays
flexibility
processing,
it
experiences
crosslinking
when
exposed
to
light
irradiation,
supporting
development
with
adjustable
mechanical
characteristics.
The
drug
delivery
landscape
has
been
reshaped
hydrogels,
offering
a
favorable
platform
for
controlled
sustained
release
therapeutic
actives.
tunable
physicochemical
precise
modulation
kinetics
release,
ensuring
optimal
effectiveness.
In
tissue
engineering,
perform
an
essential
role
design
scaffold,
providing
biomimetic
environment
conducive
cell
adhesion,
proliferation,
differentiation.
Incorporating
three-dimensional
printing
further
improves
its
applicability
developing
complicated
constructs
spatial
precision.
Wound
healing
applications
showcase
bioactive
dressings,
fostering
microenvironment
regeneration.
inherent
biocompatibility
provide
efficiency
closure
wounds
repair.
stand
at
forefront
innovation,
addressing
diverse
challenges
delivery,
wound
healing.
This
review
provides
comprehensive
overview,
in-depth
understanding
hydrogel's
potential
impact
on
progressing
sciences.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Abstract
Photothermal
therapy
(PTT)
is
widely
used
in
wound
healing
because
it
produces
heat
under
near‐infrared
irradiation,
eliminating
bacterial
infections.
However,
excessive
production
of
reactive
oxygen
species
(ROS)
occurs
during
PTT,
which
causes
oxidative
stress
damage.
In
this
study,
a
nanozyme,
PDA‐MnO
2
(PM),
synthesized
and
encapsulated
the
needle
tip
layer
bi‐layer
GelMA
microneedle
patch
(PbMP),
has
excellent
mechanical
properties
can
easily
penetrate
skin.
study
involving
an
SD
rat
model
infected
with
S.
aureus
,
PbMP
significantly
accelerated
process
bacterially
challenged
wounds,
resulting
better
blood
vessel
growth,
cell
proliferation,
collagen
biosynthesis
than
other
dressings.
The
experiment
shows
that
PM
nanoparticles
improve
photothermal
conversion
efficiency
activate
SOD
CAT,
efficient
cascade
enzyme
reaction
system
to
eliminate
ROS
PTT
process.
This
describes
highly
effective
nanozyme
hydrogel
platform
synergistic
antibacterial
effects
on
healing.
