Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

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Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Language: Английский

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Copper‐Based Nanozymes: Potential Therapies for Infectious Wounds

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Bacterial infections are a significant obstacle to the healing of acute and chronic wounds, such as diabetic ulcers burn injuries. Traditional antibiotics primary treatment for bacterial infections, but they present issues antibiotic resistance, limited efficacy, potential side effects. This challenge leads exploration nanozymes alternative therapeutic agents. Nanozymes nanomaterials with enzyme‐like activities. Owing their low production costs, high stability, scalability, multifunctionality, have emerged prominent focus in antimicrobial research. Among various types nanozymes, metal‐based offer several benefits, including broad‐spectrum activity robust catalytic properties. Specifically, copper‐based (CuNZs) shown considerable promoting wound healing. They exhibit strong effects, reduce inflammation, enhance tissue regeneration, making them highly advantageous use care. review describes dual functions CuNZs combating infection facilitating repair. Recent advancements design synthesis CuNZs, evaluating promotion, biosafety both vitro vivo on basis core components, critically important.

Language: Английский

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Zinc Oxide‐Enhanced Copper Sulfide Nanozymes Promote the Healing of Infected Wounds by Activating Immune and Inflammatory Responses

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Bacterial infection and an excessive inflammatory response are two major factors that affect the healing of infected wounds. The zinc oxide/copper sulfide (ZnO-CuS) microspheres (MSs) developed in this work can kill bacteria resist inflammation. ZnO-CuS exhibits different enzyme-like activities depending on pH. In acidic environments, peroxidase-like (POD-like) activity convert hydrogen peroxide (H

Language: Английский

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Engineered extracellular vesicles for tissue repair and regeneration

Burns & Trauma, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Abstract Extracellular vesicles (EVs) are heterogeneous membrane-like secreted by living cells that involved in many physiological and pathological processes act as intermediaries of intercellular communication molecular transfer. Recent studies have shown EVs from specific sources regulate tissue repair regeneration delivering proteins, lipids, nucleic acids to target signaling molecules. Nanotechnology breakthroughs facilitated the development exploration engineered for repair. Enhancements through gene editing, surface modification, content modification further improved their therapeutic efficacy. This review summarizes potential regeneration, mechanisms action, research progress regenerative medicine. highlights design logic typical examples explores prospects The aim this is provide new insights into applications, thereby expanding use

Language: Английский

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ZnO‐CuS/F127 Hydrogels with Multienzyme Properties for Implant‐Related Infection Therapy by Inhibiting Bacterial Arginine Biosynthesis and Promoting Tissue Repair

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract Implant‐related infections are characterized by the formation of bacterial biofilms. Current treatments have various drawbacks. Nanozymes with enzyme‐like activity can produce highly toxic substances to kill bacteria and remove biofilms without inducing drug resistance. However, it is difficult for current monometallic nanozymes function well in complex biofilm environments. Therefore, development multimetallic efficient multienzyme activities crucial. In present study, bimetallic nanozyme, ZnO‐CuS nanoflowers peroxidase (POD), glutathione oxidase (GSH‐Px), catalase (CAT) successfully synthesized via calcination loaded into F127 hydrogels treatment implant‐related infections. The ability bind key antimicrobial activity. addition, H 2 O disrupt metabolism MRSA , including arginine synthesis, nucleotide excision repair, energy metabolism, protein synthesis. ZnO‐CuS/F127 hydrogel combination has been demonstrated be effective clearing infection facilitating switch M1 macrophages M2‐repairative phenotype implant mice. Furthermore, favorable biosafety, their toxicity negligible. provided a promising biomedical strategy healing infections, highlighting potential clinical applications.

Language: Английский

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“All-in-one” self-healing and injectable cationic guar gum hydrogel dressing functionalized by bioactive complexes composed of natural small molecules

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133517 - 133517

Published: July 1, 2024

Language: Английский

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A Highly Stable, Multifunctional Janus Dressing for Treating Infected Wounds

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: July 7, 2024

Abstract The limited and unstable absorption of excess exudate is a major challenge during the healing infected wounds. In this study, highly stable, multifunctional Janus dressing with unidirectional transfer capacity fabricated based on single poly(lactide caprolactone) (PLCL). success method relies an acid hydrolysis reaction that transforms PLCL fibers from hydrophobic to hydrophilic in situ. resulting interfacial affinity between hydrophilic/phobic endows structure excellent liquid high structural stability against repeated stretching, bending, twisting. Various other functions, including wound status detection, antibacterial, antioxidant, anti‐inflammatory properties, are also integrated into by incorporating phenol red epigallocatechin gallate. An vivo methicillin‐resistant Staphylococcus aureus ‐infected model confirms dressing, capability remove site, not only facilitates epithelialization collagen deposition, but ensures low inflammation angiogenesis, thus reaching ideal closure rate up 98.4% day 14. simple structure, multiple easy fabrication may offer promising strategy for treating chronic wounds, rooted challenges bacterial infection, excessive exudate, persistent inflammation.

Language: Английский

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Combinatorial therapeutic enzymes to combat multidrug resistance in bacteria

Life Sciences, Journal Year: 2024, Volume and Issue: 353, P. 122920 - 122920

Published: July 22, 2024

Language: Английский

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Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101495 - 101495

Published: Jan. 15, 2025

Language: Английский

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