NH2-MIL-88B@TP-TA@CuS for Photothermal Catalytic Synergistic Antibacterial Activity DOI

Congcong Lou,

Liqin Zhu, Fei Yang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 242, P. 114094 - 114094

Published: July 14, 2024

Language: Английский

Multifunctional self-healing and pH-responsive hydrogel dressing based on cationic guar gum and hyaluronic acid for on-demand drug release DOI
Yan Wang, Chao Yang, Weigang Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140326 - 140326

Published: Jan. 1, 2025

Language: Английский

Citations

1
Quaternized chitosan-based biomimetic nanozyme hydrogels with ROS scavenging, oxygen generating, and antibacterial capabilities for diabetic wound repair DOI
Ye Wang, Chong Chen, Changyuan He

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122865 - 122865

Published: Oct. 18, 2024

Language: Английский

Citations

8
Synergistic Effects of Shed-Derived Exosomes, Cu2+, and an Injectable Hyaluronic Acid Hydrogel on Antibacterial, Anti-inflammatory, and Osteogenic Activity for Periodontal Bone Regeneration DOI
Yiqiang Yu, Xuejing Li, Ying Qiao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(26), P. 33053 - 33069

Published: June 20, 2024

The primary pathology of periodontitis involves the gradual deterioration periodontal tissues resulting from inflammatory reaction triggered by bacterial infection. In this study, a novel drug for pocket injection, known as Shed-Cu-HA hydrogel, was developed incorporating copper ions (Cu2+) and Shed-derived exosomes (Shed-exo) inside hyaluronic acid (HA) hydrogel. Suitable concentrations Cu2+ Shed-exo released enhanced cell viability proliferation human ligament stem cells. Additionally, demonstrated remarkable antibacterial effects against key pathogen (Aa) owing to synergistic effect HA. Furthermore, material effectively suppressed macrophage response via IL-6/JAK2/STAT3 pathway. Moreover, Shed-Cu-HA, combining inflammation-regulating properties HA with osteogenic activity Cu2+, upregulated expression genes proteins associated differentiation. experimental findings mouse model that administration reduced extent infiltration infections in gingival facilitated regeneration bone collagen after 2 4 weeks injection. Consequently, it holds significant prospects future applications treatment.

Language: Английский

Citations

6
Recent Progress in antibacterial hydrogel coatings for targeting biofilm to prevent orthopedic implant-associated infections DOI Creative Commons

Mengxuan Wang,

Yawen Zheng,

Chuqiang Yin

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 22, 2023

The application of orthopedic implants for bone tissue reconstruction and functional restoration is crucial patients with severe fractures defects. However, the abiotic nature allows bacterial adhesion colonization, leading to formation biofilms on implant surface. This can result in failure complications such as osteomyelitis septic arthritis. emergence antibiotic-resistant bacteria limited efficacy drugs against have increased risk implant-associated infections (OIAI), necessitating development alternative therapeutics. In this regard, antibacterial hydrogels based repelling, contact killing, drug delivery, or external assistance strategies been extensively investigated coating through surface modification, offering a promising approach target biofilm prevent OIAI. review provides an overview recent advancements hydrogel coatings preventing OIAI by targeting formation. topics covered include: (1) mechanisms underlying occurrence role exacerbating development; (2) current impart anti-biofilm properties involved treating article aims summarize progress prevention, providing valuable insights facilitating prognostic markers design effective implants.

Language: Английский

Citations

13
Sprayable, thermosensitive hydrogels for promoting wound healing based on hollow, porous and pH-sensitive ZnO microspheres DOI

Wei Zhang,

Hongshu Jing,

Qiang Niu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(31), P. 7519 - 7531

Published: Jan. 1, 2024

A solvothermal method and the subsequent heat treatment process were developed to fabricate hollow ZnO particles with hierarchical pores on a large scale. The as-obtained hollow, porous microspheres tunable sizes, high specific surface areas, pH sensitivity, antibacterial properties, adsorption capacities showed significant advantages for drug delivery. Sprayable hydrogels containing curcumin nanoparticles (CNPs) prepared accelerate wound healing. water-dispersed CNPs promoted both migration of fibroblasts angiogenesis an aqueous solution Pluronic F127 (a temperature-sensitive phase-change hydrogel material) was shown be effective choice medical dressings. experimental data suggest that can loaded additional achieve continuous long-term therapeutic effects.

Language: Английский

Citations

4
Metal-based antimicrobial agents in wound Dressings: Infection management and the challenge of antibiotic resistance DOI

Haihong Peng,

Derong Dong, Sizhou Feng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160726 - 160726

Published: Feb. 1, 2025

Language: Английский

Citations

0
Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis DOI Open Access
Zhenyu Guo, Xinzhou Wang,

Jing Sun

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron‐dependent form cell death, identified as critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential gallic acid (GA)‐derived PGA‐Cu nanoparticles, enhanced with functional octapeptide (Cys‐Lys‐His‐Gly‐ d ‐Arg‐ ‐Tyr‐Lys‐Phe, SS08) to build mitochondria‐targeted nanoparticles (PGA‐Cu@SS08), embedded within hydrogel matrix nanocomposite hydrogel, explored. The show targeted localization mitochondria, effectively scavenging reactive oxygen species preserving function. abundant phenolic hydroxyl groups present on nanoparticle surface, along histidine residue SS08 peptide, endow these entities capacity chelate iron. Through RNA sequencing analysis, it discovered that PGA‐Cu@SS08 activates NRF2 signaling pathway, mitigating ferroptosis. It also reduces iron overload by inhibiting autophagy storage proteins. hydrogels exhibit excellent biocompatibility biodegradability, mechanical properties improve intervertebral (IVD) performance. continuously released from hydrogels, restoring IVD height maintaining tissue hydration levels, thus facilitating future applications for alleviating IVDD.

Language: Английский

Citations

0
Versatile spiky spindle-shaped copper-based nanocomposites: A SERS substrate for discrimination, quantification and inactivation of multiple bacteria DOI

Zhengyu Gu,

Tingting Chen,

Duntao Zu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137448 - 137448

Published: March 1, 2025

Language: Английский

Citations

0
Bioinspired glycocalyx-mimetic hydrogel enabling photothermal-amplified therapeutic cascade for chronic wound healing DOI

Zongyan Quan,

Fangdie Ye,

Han Yu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 694, P. 137669 - 137669

Published: April 24, 2025

Language: Английский

Citations

0
Synergistic Antibacterial Effects of Selenium-Doped Gold Nanosheets with Notable Near Infrared-II Photothermal Conversion Against Multidrug-Resistant Bacteria DOI
Li‐Juan Han, Qi He, Ying Wang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: unknown, P. 135394 - 135394

Published: Sept. 1, 2024

Language: Английский

Citations

3