International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139062 - 139062
Published: Dec. 1, 2024
Language: Английский
Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 284, P. 111653 - 111653
Published: July 2, 2024
Language: Английский
Citations
9
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155139 - 155139
Published: Aug. 24, 2024
Language: Английский
Citations
8
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Oral ulcer wounds are difficult to heal due bacterial infections, persistent inflammatory responses, and excessive reactive oxygen species (ROS). Therefore, the elimination of bacteria, removal ROS, reduction inflammation prerequisites for treatment mouth wounds. In this study, oligomeric proanthocyanidins (OPC) 3-(aminomethyl)phenylboronic acid-modified hyaluronic acid (HP) were used form polymer gels through dynamic covalent borate bonds. Minocycline hydrochloride (MH) was then loaded into gel, a multifunctional MH/OPC-HP microneedles (MNs) with ROS-responsive properties prepared using vacuum method. The MNs can rapidly release MH in diffusive manner sustainably OPC response ROS. gel-based extended retention oral ulcers, leading prolonged ROS scavenging effects. Cytocompatibility hemocompatibility tests showed that had good biocompatibility. Antibacterial experiments demonstrated exhibited excellent antibacterial vitro indicated could effectively clear reduce oxidative stress damage, inhibit M1-type macrophage polarization, induce M2-type polarization. Furthermore, vivo revealed pro-inflammatory cytokines, promote neovascularization, accelerate epithelial healing significantly rat model wound infection. summary, hold promise as therapeutic strategy enhancing
Language: Английский
Citations
1
Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 789 - 789
Published: June 28, 2024
Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair function of cells involved bone formation, posing a serious challenge for repair. Due to potent ROS scavenging ability, as well potential anti-inflammatory immunomodulatory activities, antioxidants play an indispensable role maintenance protection health have gained increasing attention recent years. This narrative review aims give overview main research directions on application antioxidant compounds repair over past decade. In addition, positive effects various their biomaterial delivery systems summarized provide new insights exploring antioxidant-based strategies
Language: Английский
Citations
4
Small Structures, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
The increasing demand of advanced biomedical materials for bone repair and regeneration has spurred significant research in recent years. While traditional hydrogels offer promising biocompatibility easy fabrication, their application reconstruction is often impeded by inadequate structural integrity biological functions. Graphene oxide (GO) emerged as a transformative additive, renowned its exceptional mechanical chemical properties, well ability to enhance the hydrogels. In this study, incorporation GO into chitosan (CS) investigated, achieving bioinspired with enhanced strength stability, which are crucial supporting regeneration. Additionally, self‐assembled synthetic peptide nanofibers (PNFs) employed facilitate biomimetic mineralization hydrogels, critical process effective remodeling. This innovative composite hydrogel not only achieves but also exhibits osteogenic, pro‐angiogenic, antioxidant properties essential repair. novel method takes advantage distinctive GO, PNFs, biomass providing robust material solution potential significantly advance field tissue engineering.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1254 - 1254
Published: Jan. 31, 2025
The increasing prevalence of bacterial infections and the rise in antibiotic resistance have prompted search for alternative therapeutic strategies. One promising approach involves combining plant-based bioactive substances with nanoparticles, which demonstrated improved antimicrobial activity compared to their free forms, both vitro, vivo, clinical studies. This not only improves stability but also enables targeted delivery cells, reducing side effects minimising risk development, leading more effective treatments. narrative review explores benefits plant compounds (berberine, catechin, chelerythrine, cinnamaldehyde, ellagic acid, proanthocyanidin, sanguinarine) nanoparticles treatment (caused by Staphylococcus aureus, Enterococcus spp., Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli, Serratia marcescens, Pseudomonas aeruginosa), highlighting potential this overcome limitations traditional therapies. Ultimately, strategy offers a fight against resistant strains, paving way development sustainable
Language: Английский
Citations
0
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 189, P. 232 - 253
Published: Oct. 11, 2024
Language: Английский
Citations
3
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)
Published: Nov. 27, 2024
Abstract Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics regeneration. However, the widespread application of bioactive is limited by their low accumulation and short half-lives in vivo. Hydrogels emerged as ideal carriers to address these challenges, offering potential prolong retention times at lesion sites, extend vivo mitigate side effects, avoid burst release, promote adsorption under physiological conditions. This review systematically summarizes recent advances development molecule-loaded hydrogels regeneration, encompassing applications cranial defect repair, femoral periodontal regeneration with underlying diseases. Additionally, this discusses current strategies aimed improving release profiles through stimuli-responsive delivery, carrier-assisted sequential delivery. Finally, elucidates existing challenges future directions hydrogel encapsulated field
Language: Английский
Citations
3
Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 108 - 126
Published: July 16, 2024
Language: Английский
Citations
2
Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 344 - 344
Published: Feb. 1, 2024
In orthopedics, the repair of bone defects remains challenging. previous research reports, magnesium phosphate cements (MPCs) were widely used because their excellent mechanical properties, which have been in field orthopedic medicine. We built a new k-struvite (MPC) cement obtained from zinc oxide (ZnO) and assessed its osteogenic properties. Zinc-doped (ZMPC) is novel material with good biocompatibility degradability. This article summarizes preparation method, physicochemical biological properties ZMPC through on this material. The results show that has same strength toughness (25.3 ± 1.73 MPa to 20.18 2.11 MPa), meet requirements repair. Furthermore, can gradually degrade (12.27% 1.11% 28 days) promote differentiation (relative protein expression level increased 2–3 times) rat marrow mesenchymal stem cells (rBMSCs) vitro. addition, vivo confirmation revealed regeneration calvarial defect model compared MPC alone. Therefore, broad application prospects expected be an important
Language: Английский
Citations
1