Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
137(1)
Published: Aug. 22, 2024
Abstract
Single‐atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)‐mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single‐atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi‐enzyme
mimetic
MoCu
dual‐atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme‐like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near‐infrared
II
bio‐window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high‐efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Aug. 22, 2024
Single-atom
nanozymes
(SAzymes)
with
ultrahigh
atom
utilization
efficiency
have
been
extensively
applied
in
reactive
oxygen
species
(ROS)-mediated
cancer
therapy.
However,
the
high
energy
barriers
of
reaction
intermediates
on
single-atom
sites
and
overexpressed
antioxidants
tumor
microenvironment
restrict
amplification
oxidative
stress,
resulting
unsatisfactory
therapeutic
efficacy.
Herein,
we
report
a
multi-enzyme
mimetic
MoCu
dual-atom
nanozyme
(MoCu
DAzyme)
various
catalytic
active
sites,
which
exhibits
peroxidase,
oxidase,
glutathione
(GSH)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
mimicking
activities.
Compared
Mo
SAzyme,
introduction
Cu
atoms,
formation
synergetic
effects
among
enhance
substrate
adsorption
reduce
barrier,
thereby
endowing
DAzyme
stronger
Benefiting
from
above
enzyme-like
activities,
can
not
only
generate
multiple
ROS,
but
also
deplete
GSH
block
its
regeneration
to
trigger
cascade
stress.
Additionally,
strong
optical
absorption
near-infrared
II
bio-window
endows
remarkable
photothermal
conversion
performance.
Consequently,
achieves
high-efficiency
synergistic
treatment
incorporating
collaborative
therapy
This
work
will
advance
applications
DAzymes
provide
valuable
insights
for
nanocatalytic
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 24, 2024
Abstract
Oxidative
stress
and
inflammation
are
at
the
root
of
a
multitude
diseases.
Treatment
these
conditions
is
often
necessary
but
current
standard
therapies
to
fight
excessive
reactive
oxygen
species
(ROS)
ineffective
or
complicated
by
substantial
safety
concerns.
Nanozymes
emerging
nanomaterials
with
intrinsic
enzyme‐like
properties
that
hold
great
promise
for
effective
cancer
treatment,
bacterial
elimination,
anti‐inflammatory/anti‐oxidant
therapy.
While
there
rapid
progress
in
tailoring
their
catalytic
activities
as
evidenced
recent
integration
single‐atom
catalysts
(SACs)
create
next‐generation
nanozymes
superior
activity,
selectivity,
stability,
better
understanding
tuning
profile
imperative
successful
clinical
translation.
This
review
outlines
applied
assessment
approaches
provides
comprehensive
summary
knowledge
therapeutic
nanozymes.
Overall,
so
far
show
good
vitro
vivo
biocompatibility
despite
considerable
differences
composition
enzymatic
activities.
However,
investigations
mostly
cover
limited
set
basic
toxicological
endpoints,
which
do
not
allow
thorough
deep
assessment.
Ultimately,
remaining
research
gaps
should
be
carefully
addressed
future
studies
highlighted,
optimize
early
pre‐clinical
development.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 2, 2024
Abstract
Small
molecule‐based
photothermal
agents
(PTAs)
hold
promising
future
for
therapy;
however,
unexpected
inactivation
exerts
negative
impacts
on
their
application
clinically.
Herein,
a
self‐regenerating
PTA
strategy
is
proposed
by
integrating
2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic
acid)
radical
cation
(ABTS
•+
)
with
thermodynamic
agent
(TDA)
2,2′‐azobis[2‐(2‐imidazolin‐2‐yl)
propane]
dihydrochloride
(AIPH).
Under
NIR
laser,
the
effect
of
ABTS
accelerates
production
alkyl
radicals
AIPH,
which
activates
regeneration
,
thus
creating
continuous
positive
feedback
loop
between
and
effects.
The
combination
leads
to
tandem
tumor
therapy.
In
vitro
in
vivo
experiments
confirm
that
synergistic
action
thermal
ablation,
damage,
oxidative
stress
effectively
realizes
suppression.
This
work
offers
approach
address
unwanted
PTAs
provides
valuable
insights
optimizing
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
30, P. 101447 - 101447
Published: Jan. 5, 2025
Chemodynamic
therapy
(CDT)
is
an
emerging
antitumor
strategy
utilizing
iron-initiated
Fenton
reaction
to
destroy
tumor
cells
by
converting
endogenous
H2O2
into
highly
toxic
hydroxyl
radical
(OH).
However,
the
intratumoral
overexpressed
glutathione
(GSH)
and
deficient
acid
greatly
reduce
CDT
efficacy
because
of
OH
scavenging
decreased
production
efficiency.
Even
worse,
various
physiological
barriers,
especially
in
glioma,
further
put
brakes
on
targeted
delivery
agents.
Herein,
exploring
thiol
potential
5,5'-dithiobis-2-nitrobenzoic
(DTNB),
we
have
constructed
a
tailored
biomimetic
nanoreactor
improve
glioma
through
synchronous
GSH
exhaustion
acidity
elevation.
The
was
fabricated
employing
DTNB
drive
nano-assembly
BSA
molecules,
followed
loading
carrier
onto
cell
surface
neutrophils
via
disulfide-thiol
exchange.
Upon
sensing
inflammatory
signal,
hijacked
efficiently
targets
site,
which
then
dually
depletes
disulfide
bond
stabilizing
nanostructure
following
liberated
Fe
(III).
In
particular,
simultaneously
released
can
not
only
consume
residual
GSH,
but
also
produce
5-thio-2-nitrobenzoic
(TNB)
promptly,
resulting
accelerated
reaction.
Through
vitro
vivo
experiments,
demonstrate
exhaustive
regulation
chemistry
could
potentially
serve
as
novel
for
glioma.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Chemodynamic
therapy
(CDT)
has
garnered
significant
attention
in
the
field
of
tumor
due
to
its
ability
convert
overexpressed
hydrogen
peroxide
(H
2
O
)
tumors
into
highly
toxic
hydroxyl
radicals
(•OH)
through
metal
ion‐mediated
catalysis.
However,
effectiveness
CDT
is
hindered
by
low
catalyst
efficiency,
insufficient
intra‐tumor
H
level,
and
excessive
glutathione
(GSH).
In
this
study,
a
pH/GSH
dual
responsive
bimetallic
nanocatalytic
system
(CuFeMOF@GOx@Mem)
developed
modifying
red
blood
cell
membranes
onto
glucose
oxidase
(GOx)‐loaded
Fe‐Cu
MOFs,
enhancing
efficacy
triple‐enhanced
way
self‐supply,
catalysts
self‐cycling,
GSH
self‐elimination.
Upon
accumulation
tissues
facilitated
membrane,
GOx
initiates
reaction
with
generate
gluconic
acid
situ.
Subsequently,
reduced
pH
triggers
release
Fe
3+
Cu
2+
from
CuFeMOF@GOx@Mem,
which
immediately
turned
+
GSH,
activating
‐mediated
Fenton
reaction.
More
importantly,
can
also
act
as
an
accelerator
/Fe
conversion,
meanwhile,
generated
be
further
GSH.
Consequently,
sustained
well
elimination
are
achieved
simultaneously,
providing
unique
approach
for
improving
anti‐tumor
CDT.
