RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(7), P. 5117 - 5123
Published: Jan. 1, 2025
Polyphenols
exhibit
strong
antioxidant,
and
anti-inflammatory
but
are
limited
by
chemical
instability
low
bioavailability.
To
address
these
challenges,
we
developed
polyphenol-amino
acid
conjugates
that
self-assemble
into
stable
nanospheres,
enhancing
their
stability
These
nanoparticles
demonstrate
significantly
improved
ROS
scavenging
efficiency
promote
cell
proliferation
in
vitro.
The
incorporation
of
amino
acids
enhances
biocompatibility
facilitates
effective
elimination.
offer
a
multifaceted
therapeutic
strategy
to
mitigate
oxidative
stress,
overcoming
traditional
antioxidant
limitations
through
advanced
nanotechnology.
This
approach
contributes
the
development
next-generation
wound
care
solutions
with
enhanced
efficacy
safety
profiles.
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
98, P. 102323 - 102323
Published: May 9, 2024
Oxidative
stress
is
one
of
the
main
driving
mechanisms
intervertebral
disc
degeneration(IDD).
has
been
associated
with
inflammation
in
disc,
cellular
senescence,
autophagy,
and
epigenetics
cells.
It
above
pathological
are
closely
linked
through
common
hub
reactive
oxygen
species(ROS),
promote
each
other
process
degeneration
development
disease.
This
reveals
important
role
oxidative
IDD,
importance
great
potential
IDD
therapy
targeting
stress.
The
efficacy
traditional
unstable
or
cannot
be
maintained.
In
recent
years,
due
to
rise
materials
science,
many
bioactive
functional
have
applied
treatment
combination
drugs,
satisfactory
achieved.
At
present,
research
review
antioxidant
not
complete.
Based
on
existing
studies,
mechanism
were
summarized
this
paper,
strategies
based
emerging
reviewed.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(2), P. 203 - 203
Published: Feb. 5, 2024
Antioxidant
peptides
are
currently
a
hotspot
in
food
science,
pharmaceuticals,
and
cosmetics.
In
different
fields,
the
screening,
activity
evaluation,
mechanisms,
applications
of
antioxidant
pivotal
areas
research.
Among
these
topics,
efficient
screening
stands
at
forefront
cutting-edge
To
this
end,
with
novel
technologies
has
significantly
accelerated
research
process,
gradually
replacing
traditional
approach.
After
screened
identified,
time-consuming
evaluation
is
another
indispensable
procedure,
especially
vivo
models.
Cellular
rodent
models
have
been
widely
used
for
whilst
non-rodent
provide
an
solution,
even
potential
high-throughput
screening.
Meanwhile,
further
molecular
mechanisms
can
elucidate
essence
underlying
activity,
which
related
to
several
signaling
pathways,
including
Keap1-Nrf2/ARE,
mitochondria-dependent
apoptosis,
TGF-β/SMAD,
AMPK/SIRT1/PGC-1α,
PI3K/Akt/mTOR,
NF-κB.
Last
but
not
least,
broad
manufacture,
therapy,
cosmetics
industry,
requires
systematic
review.
This
review
introduces
peptides,
categorized
new
vision.
A
wide
range
assays,
encompassing
cellular
models,
as
well
provided
comprehensive
manner.
addition,
recent
advances
analyzed
specific
cases.
Finally,
production,
systematically
reviewed.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(28)
Published: March 14, 2024
Abstract
Achieving
optimal
implant
restoration
hinges
on
both
robust
osseointegration
as
the
structural
foundation
and
favorable
osseoperception
for
advanced
masticatory
function.
The
significance
of
nerve
innervation
in
peri‐implant
environment
cornerstone
is
often
underestimated.
Despite
integral
role
endogenous
electric
fields
(EFs)
human
body,
particularly
electrosensitive
tissues
like
tissue,
current
approach
involving
external
electrical
stimulation
invasive
not
clinically
applicable.
present
study
introduces
a
conductive
hydrogel
designed
to
respond
EFs,
aiming
foster
regeneration
around
dental
implants
coordinate
osseoperception.
promotes
neurite
outgrowth
by
upregulating
intracellular
Ca
2+
concentration
activating
subsequent
pathways.
Furthermore,
enhanced
release
neuropeptides
from
neurocells
improves
osteogenesis
osteoblasts.
impact
also
thoroughly
investigated
vivo.
This
represents
unique
strategy
enhancing
within
EFs
environment.
advancement
opens
door
achieving
physiological
psychological
integration
implants.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116432 - 116432
Published: March 22, 2024
Oxidative
stress
results
from
a
persistent
imbalance
in
oxidation
levels
that
promotes
oxidants,
playing
crucial
role
the
early
and
sustained
phases
of
DNA
damage
genomic
epigenetic
instability,
both
which
are
intricately
linked
to
development
tumors.
The
molecular
pathways
contributing
carcinogenesis
this
context,
particularly
those
related
double-strand
single-strand
breaks
DNA,
serve
as
indicators
due
cancer
cases,
well
factors
instability
through
ectopic
expressions.
has
been
considered
therapeutic
target
for
many
years,
an
increasing
number
studies
have
highlighted
promising
effectiveness
natural
products
treatment.
In
regard,
we
present
significant
research
on
targeting
oxidative
using
molecules
underscore
essential
cancer.
consequences
stress,
especially
also
offer
prospects.
use
epi-drugs
capable
modulating
reorganizing
network
is
beginning
emerge
remarkably.
review,
emphasize
close
connections
between
tumor
transformation,
while
highlighting
substances
antioxidants
anti-tumoral
context.
Gels,
Journal Year:
2024,
Volume and Issue:
10(2), P. 125 - 125
Published: Feb. 3, 2024
In
recent
years,
the
incidence
of
chronic
pancreatitis
has
increased
significantly.
Pancreatic
calculi
obstruct
pancreatic
duct
and
induce
abdominal
pain
in
patients.
stenting
is
major
treatment
option
for
with
calculi.
this
study,
a
new
kind
drug-eluting
stent,
stent
coated
by
methacrylated
gelatin
(GelMA)
hydrogel
loaded
citric
acid
(CA),
was
designed
interventional
The
CA
loading
capacity
reached
up
to
0.7
g
CA/g
hydrogel-coated
stent.
GelMA
coating
higher
mechanical
strength
lower
swelling
performance
after
CA.
vitro
experiments
stents
exhibited
good
sustained
release
can
be
dissolved
almost
3
days.
also
showed
blood
compatibility
cell
compatibility.
This
research
important
clinical
value
