Journal of the American Chemical Society,
Journal Year:
2019,
Volume and Issue:
141(16), P. 6601 - 6608
Published: April 3, 2019
We
report
an
ultrasound-driven
gold-nanoshell-functionalized
polymer
multilayer
tubular
nanoswimmer
that
can
photomechanically
perforate
the
membrane
of
a
cancer
cell
by
assistance
near-infrared
(NIR)
light.
The
nanoswimmers
were
constructed
template-assisted
layer-by-layer
technique
and
subsequent
functionalization
Au
nanoshells
inside
big
opening.
exhibit
efficient
controllable
movement
toward
target
cells
through
manipulation
acoustic
field.
Next,
with
end-on
attachment
onto
HeLa
achieve
poration
within
0.1
s
under
irradiation
NIR
experimental
theoretical
results
suggest
instantaneous
photothermal
effect
provides
enough
photomechanical
force
to
open
membrane.
Such
NIR-light-assisted
nanoswimmers-enabled
possesses
various
advantages
including
active
targeting,
short
time,
precision
in
single
conventional
chemical
physical
techniques
could
not
and,
thus,
considerable
promise
variety
biomedical
applications
such
as
gene
delivery
artificial
insemination.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(8), P. 4999 - 5041
Published: March 31, 2021
Manipulation
and
navigation
of
micro
nanoswimmers
in
different
fluid
environments
can
be
achieved
by
chemicals,
external
fields,
or
even
motile
cells.
Many
researchers
have
selected
magnetic
fields
as
the
active
actuation
source
based
on
advantageous
features
this
strategy
such
remote
spatiotemporal
control,
fuel-free,
high
degree
reconfigurability,
programmability,
recyclability,
versatility.
This
review
introduces
fundamental
concepts
advantages
micro/nanorobots
(termed
here
"MagRobots")
well
basic
knowledge
materials,
setups
for
manipulation,
field
configurations,
symmetry-breaking
strategies
effective
movement.
These
are
discussed
to
describe
interactions
between
fields.
Actuation
mechanisms
flagella-inspired
MagRobots
(i.e.,
corkscrew-like
motion
traveling-wave
locomotion/ciliary
stroke
motion)
surface
walkers
surface-assisted
motion),
applications
other
propulsion
approaches,
stimulation
beyond
provided
followed
fabrication
techniques
(quasi-)spherical,
helical,
flexible,
wire-like,
biohybrid
MagRobots.
Applications
targeted
drug/gene
delivery,
cell
minimally
invasive
surgery,
biopsy,
biofilm
disruption/eradication,
imaging-guided
delivery/therapy/surgery,
pollution
removal
environmental
remediation,
(bio)sensing
also
reviewed.
Finally,
current
challenges
future
perspectives
development
magnetically
powered
miniaturized
motors
discussed.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
33(4)
Published: Dec. 4, 2020
Abstract
Micro‐/nanorobots
(m‐bots)
have
attracted
significant
interest
due
to
their
suitability
for
applications
in
biomedical
engineering
and
environmental
remediation.
Particularly,
vivo
diagnosis
intervention
been
the
focus
of
extensive
research
recent
years
with
various
clinical
imaging
techniques
being
applied
localization
tracking.
The
successful
integration
well‐designed
m‐bots
surface
functionalization,
remote
actuation
systems,
becomes
crucial
step
toward
applications,
especially
uses.
This
review
thus
addresses
four
different
aspects
m‐bots:
design/fabrication,
actuation,
localization.
diagnosis,
sensing,
microsurgery,
targeted
drug/cell
delivery,
thrombus
ablation,
wound
healing
are
reviewed
from
these
viewpoints.
developed
m‐bot
systems
comprehensively
compared
evaluated
based
on
characteristics.
current
challenges
directions
future
this
field
summarized.
Advanced Functional Materials,
Journal Year:
2018,
Volume and Issue:
28(25)
Published: April 14, 2018
After
the
tremendous
advances
over
past
two
decades,
micro-/nanorobots
can
effectively
convert
other
forms
of
energy
into
propulsion
and
movement,
as
well
be
navigated
to
targeted
locations
under
physiological
conditions
environments.
They
have
been
demonstrated
potential
load,
transport,
deliver
therapeutic
payloads
directly
disease
sites,
thereby
improving
efficacy
reducing
systemic
side
effects
highly
toxic
drugs.
In
this
feature
article,
various
modalities
ranging
from
chemical/biochemical
reactions
external
fields,
motile
microorganisms
are
summarized
commented
in
terms
driving
forces
required
by
automotive
motion
biological
media,
biocompatibility,
corresponding
advantages
limitations
biomedical
applications.
Then,
latest
developments
vitro
vivo
active
drug
delivery
based
on
discussed
detail.
The
challenges
future
prospects
also
highlighted
end.
With
ever
booming
research
enthusiasm
field
increasing
multidisciplinary
cooperation,
with
intelligence
multifunctions
will
emerge
near
future,
which
would
a
profound
impact
treatment
diseases.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(21)
Published: Oct. 4, 2020
Advances
in
medical
robots
promise
to
improve
modern
medicine
and
the
quality
of
life.
Miniaturization
these
robotic
platforms
has
led
numerous
applications
that
leverages
precision
medicine.
In
this
review,
current
trends
micro
nanorobotics
for
therapy,
surgery,
diagnosis,
imaging
are
discussed.
The
use
nanorobots
still
faces
technical,
regulatory,
market
challenges
their
widespread
clinical
settings.
Nevertheless,
recent
translations
from
proof
concept
vivo
studies
demonstrate
potential
toward
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(5), P. 5365 - 5403
Published: Feb. 1, 2021
Over
the
past
15
years,
field
of
microrobotics
has
exploded
with
many
research
groups
from
around
globe
contributing
to
numerous
innovations
that
have
led
exciting
new
capabilities
and
important
applications,
ranging
in
vivo
drug
delivery,
intracellular
biosensing,
environmental
remediation,
nanoscale
fabrication.
Smart
responsive
materials
had
a
profound
impact
on
imparted
small-scale
robots
functionalities
distinct
capabilities.
We
identified
four
large
categories
where
majority
future
efforts
must
be
allocated
push
frontiers
microrobots
smart
can
major
such
advances.
These
areas
are
propulsion
biocompatibility
microrobots,
cooperation
between
individual
units
human
operators,
finally,
intelligence
microrobots.
In
this
Review,
we
look
critically
at
latest
developments
these
discuss
how
contribute
progress
will
set
stage
for
next
generation
intelligent
programmable
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
33(6)
Published: June 24, 2020
Abstract
Self‐propelled
micro‐
and
nanomotors
(MNMs)
have
shown
great
potential
for
applications
in
the
biomedical
field,
such
as
active
targeted
delivery,
detoxification,
minimally
invasive
diagnostics,
nanosurgery,
owing
to
their
tiny
size,
autonomous
motion,
navigation
capacities.
To
enter
clinic,
MNMs
request
biodegradability
of
manufacturing
materials,
biocompatibility
chemical
fuels
or
externally
physical
fields,
capability
overcoming
various
biological
barriers
(e.g.,
biofouling,
blood
flow,
blood–brain
barrier,
cell
membrane),
vivo
visual
positioning
navigation.
Herein,
recent
advances
synthetic
motion‐tracking
imaging
techniques
are
highlighted.
The
challenges
future
research
priorities
also
addressed.
With
continued
attention
innovation,
it
is
believed
that,
future,
will
pave
way
improve
drug
delivery
efficiency.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(22), P. 8088 - 8112
Published: Jan. 1, 2020
This
article
introduces
how
various
complex
media
impact
the
propulsion
of
micro/nanorobotics
and
highlights
emerging
technological
approaches
to
enhance
locomotion
in
environments
toward
practical
medical
applicationsin
vivo.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(15)
Published: Feb. 14, 2018
Abstract
Micro‐
and
nanorobots
have
shown
great
potential
for
applications
in
various
fields,
including
minimally
invasive
surgery,
targeted
therapy,
cell
manipulation,
environmental
monitoring,
water
remediation.
Recent
progress
the
design,
fabrication,
operation
of
these
miniaturized
devices
has
greatly
enhanced
their
versatility.
In
this
report,
most
recent
on
manipulation
small‐scale
robots
based
power
sources,
such
as
magnetic
light,
acoustic
waves,
electric
thermal
energy,
or
combinations
these,
is
surveyed.
The
design
propulsion
mechanism
micro‐
are
focus
article.
Their
fabrication
also
briefly
discussed.