Bridging Bio–Nano Science and Cancer Nanomedicine

ACS Nano, Journal Year: 2017, Volume and Issue: 11(10), P. 9594 - 9613

Published: Sept. 19, 2017

The interface of bio–nano science and cancer medicine is an area experiencing much progress but also beset with controversy. Core concepts the field—e.g., enhanced permeability retention (EPR) effect, tumor targeting accumulation, even purpose "nano" in medicine—are hotly debated. In parallel, considerable advances neighboring fields are occurring rapidly, including recent "immuno-oncology" fundamental impact it having on our understanding clinical treatment group diseases collectively known as cancer. Herein, we (i) revisit how commonly treated clinic this relates to nanomedicine; (ii) examine ongoing debate relevance EPR effect targeting; (iii) highlight ways improve next-generation nanomedicines; (iv) discuss emerging concept working (and not against) biology. While discussing these controversies, challenges, concepts, opportunities, explore new directions for field nanomedicine.

Language: Английский

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A melanin-mediated cancer immunotherapy patch

Science Immunology, Journal Year: 2017, Volume and Issue: 2(17)

Published: Nov. 11, 2017

Transdermal microneedle patch integrated with whole tumor lysate containing melanin facilitates cancer immunotherapy upon near-infrared light irradiation.

Language: Английский

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Immunomodulatory Nanosystems

Advanced Science, Journal Year: 2019, Volume and Issue: 6(17)

Published: June 21, 2019

Abstract Immunotherapy has emerged as an effective strategy for the prevention and treatment of a variety diseases, including cancer, infectious inflammatory autoimmune diseases. Immunomodulatory nanosystems can readily improve therapeutic effects simultaneously overcome many obstacles facing method, such inadequate immune stimulation, off‐target side effects, bioactivity loss agents during circulation. In recent years, researchers have continuously developed nanomaterials with new structures, properties, functions. This Review provides most advances nanotechnology immunostimulation immunosuppression. cancer immunotherapy, play essential role in cell activation tumor microenvironment modulation, well combination other antitumor approaches. encouraging outcomes from using nanomaterial vaccines against viral bacterial infections been reported. addition, nanoparticles also potentiate immunosuppressive cells Finally, challenges prospects applying to modulate immunotherapy are discussed.

Language: Английский

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Neutrophil-Based Drug Delivery Systems

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(22)

Published: March 26, 2018

Abstract White blood cells (WBCs) are a major component of immunity in response to pathogen invasion. Neutrophils the most abundant WBCs humans, playing central role acute inflammation induced by pathogens. Adhesion vasculature and tissue infiltration neutrophils key processes inflammation. Many inflammatory/autoimmune disorders cancer therapies have been found be involved activation neutrophils. A promising strategy develop novel targeted drug delivery systems is targeting exploitation activated Herein, new platform based on reviewed. There two types systems: as carriers neutrophil‐membrane‐derived nanovesicles. It discussed how nanoparticles hijack vivo deliver therapeutics across vessel barriers nanovesicles target inflamed vasculature. Finally, potential applications neutrophil‐based treating cancers presented.

Language: Английский

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Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy

Science Advances, Journal Year: 2019, Volume and Issue: 5(10)

Published: Oct. 11, 2019

Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen system based on the nanoerythrosomes derived from RBCs, inspired by splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto fusing tumor membrane-associated with nanoerythrosomes. This antigen-loaded (nano-Ag@erythrosome) elicited responses in vivo and, combination anti-programmed death ligand 1 (PD-L1) blockade, inhibited growth B16F10 and 4T1 models. We also generated model showing that "personalized nano-Ag@erythrosomes" could be achieved RBCs surgically removed tumors, which effectively reduced recurrence metastasis after surgery.

Language: Английский

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NIR‐Triggered Phototherapy and Immunotherapy via an Antigen‐Capturing Nanoplatform for Metastatic Cancer Treatment

Advanced Science, Journal Year: 2019, Volume and Issue: 6(10)

Published: March 13, 2019

Combined phototherapy and immunotherapy demonstrates strong potential in the treatment of metastatic cancers. An upconversion nanoparticle (UCNP) based antigen-capturing nanoplatform is designed to synergize phototherapies immunotherapy. In particular, this constructed via self-assembly DSPE-PEG-maleimide indocyanine green (ICG) onto UCNPs, followed by loading photosensitizer rose bengal (RB). ICG significantly enhances RB-based photodynamic therapy efficiency UCNP/ICG/RB-mal upon activation a near-infrared (NIR) laser, simultaneously achieving selective photothermal therapy. Most importantly, tumor-derived protein antigens, arising from phototherapy-treated tumor cells, can be captured retained situ, due functionality maleimide, which further enhance antigen uptake presentation antigen-presenting cells. The synergized photothermal, photodynamic, immunological effects using light-activated induces tumor-specific immune response. experiments, intratumoral administration UCNP/ICG/RB-mal, noninvasive irradiation with an NIR destroys primary tumors inhibits untreated distant tumors, poorly immunogenic, highly 4T1 mammary model. With simultaneous use anti-CTLA-4, about 84% treated tumor-bearing mice achieve long-term survival 34% develop immunity. Overall, provides promising approach for

Language: Английский

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Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

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Tailoring Nanomaterials for Targeting Tumor‐Associated Macrophages

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(19)

Published: March 18, 2019

Abstract Advances in the field of nanotechnology together with an increase understanding tumor immunology have paved way for development more personalized cancer immuno‐nanomedicines. Nanovehicles, due to their specific physicochemical properties, are emerging as key translational moieties tackling tumor‐promoting, M2‐like tumor‐associated macrophages (TAMs). Cancer immuno‐nanomedicines target TAMs primarily by blocking TAM survival or affecting signaling cascades, restricting macrophage recruitment tumors and re‐educating tumor‐promoting tumoricidal, M1‐like phenotype. Here, effector mechanisms strategies targeting summarized, followed a focus on mechanistic considerations novel Furthermore, imaging nanoparticles so forecast patient's clinical outcome, describing treatment options, observing therapy responses is also discussed. At present, that being investigated not only at basic research level but early trials. The significance TAM‐targeting biomaterials highlighted, goal facilitating future translation.

Language: Английский

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Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(34)

Published: Feb. 18, 2019

Cancer immunotherapies that harness the body's immune system to combat tumors have received extensive attention and become mainstream strategies for treating cancer. Despite promising results, some problems remain, such as limited patient response rate emergence of severe immune-related adverse effects. For most patients, therapeutic efficacy cancer immunotherapy is mainly by immunosuppressive tumor microenvironment (TME). To overcome obstacles in TME, immunomodulation factors cells (e.g., T antigen-presenting cells) should be carefully designed evaluated. Nanoengineered synthetic niches emerged highly customizable platforms with a potent capability reprogramming TME. Here, recent developments nano-biomaterials are rationally modulate TME spatiotemporal manner enhanced which highlighted.

Language: Английский

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Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(22), P. 5506 - 5526

Published: Jan. 1, 2019

Cancer immunotherapy by educating or stimulating patients' own immune systems to attack cancer cells has demonstrated promising therapeutic responses in the clinic. However, although number of approved immunotherapeutics is rapidly increasing, key challenges such as limited clinical response rate and significant autoimmunity-related adverse effects remain be resolved. Recently, it been discovered that a diverse range biomaterials-assisted local treatment methods including localized radiotherapy, chemotherapy phototherapy are able stimulate systems, often inducing immunogenic cell death (ICD). The triggered tumor-specific immunological after treatments, especially combination with checkpoint blockade (ICB) therapy, can achieve abscopal effect whole-body spreading metastatic cells, later on result memory inhibit tumor recurrence. Moreover, delivery immunomodulatory therapeutics biomaterials also an alternative strategy improve reduce side immunotherapy. In this review, we would like summarize latest advances, opportunities utilizing strategies for enhancing anticancer immunity, discuss further prospects field together how may possibly translated into use.

Language: Английский

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