Rare-Earth Doping in Nanostructured Inorganic Materials

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5519 - 5603

Published: Jan. 6, 2022

Impurity doping is a promising method to impart new properties various materials. Due their unique optical, magnetic, and electrical properties, rare-earth ions have been extensively explored as active dopants in inorganic crystal lattices since the 18th century. Rare-earth can alter crystallographic phase, morphology, size, leading tunable optical responses of doped nanomaterials. Moreover, control ultimate electronic catalytic performance nanomaterials scalable manner, enabling significant improvements energy harvesting conversion. A better understanding critical role prerequisite for development an extensive repertoire functional practical applications. In this review, we highlight recent advances associated applications many fields. This review covers key criteria doping, including basic structures, lattice environments, strategies, well fundamental design principles that enhance electrical, catalytic, magnetic material. We also discuss future research directions challenges controlling

Language: Английский

---

Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine

ACS Nano, Journal Year: 2023, Volume and Issue: 17(9), P. 7979 - 8003

Published: April 27, 2023

Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT PTT at the cellular, vascular tumor microenvironmental levels, as well translating both modalities clinic. Emerging evidence suggests that may synergize due their different mechanisms action, nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations gained momentum recent years development multimodal nanoplatforms simultaneously incorporate photodynamically- photothermally active agents. In this review, we discuss how combining can address limitations each modality alone enhance treatment safety efficacy. We provide an overview literature featuring dual nanoparticles analyze strengths various nanoparticle design strategies. also detail sequence dose affect cellular states, pathophysiology drug delivery, ultimately shaping response. Lastly, common experimental pitfalls complicate preclinical assessment propose rational guidelines elucidate underlying interactions.

Language: Английский

---

A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu₂MoS₄ for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(51)

Published: Nov. 4, 2019

The unique tumor microenvironment (TME) facilitates cancer proliferation and metastasis, it is hard to cure completely via monotherapy. Herein, a multifunctional cascade bioreactor based on hollow mesoporous Cu2 MoS4 (CMS) loaded with glucose oxidase (GOx) constructed for synergetic therapy by chemo-dynamic (CDT)/starvation therapy/phototherapy/immunotherapy. CMS harboring multivalent elements (Cu1+/2+ , Mo4+/6+ ) exhibit Fenton-like, glutathione (GSH) peroxidase-like catalase-like activity. Once internalized into the tumor, could generate ·OH CDT Fenton-like reaction deplete overexpressed GSH in TME alleviate antioxidant capability of tumors. Moreover, under hypoxia TME, react endogenous H2 O2 activating catalyzed oxidation GOx starvation accompanied regeneration . regenerated can devote realizing GOx-catalysis-enhanced CDT. Meanwhile, 1064 nm laser irradiation shows remarkable tumor-killing ability phototherapy due its excellent photothermal conversion efficiency (η = 63.3%) cytotoxic superoxide anion (·O2- generation performance. More importantly, PEGylated CMS@GOx-based synergistic combined checkpoint blockade elicit robust immune responses both effectively ablating primary tumors inhibiting metastasis.

Language: Английский

---

Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

---

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Language: Английский

---

Obstacles and opportunities in a forward vision for cancer nanomedicine

Nature Materials, Journal Year: 2021, Volume and Issue: 20(11), P. 1469 - 1479

Published: July 5, 2021

Language: Английский

---

NIR‐Triggered Phototherapy and Immunotherapy via an Antigen‐Capturing Nanoplatform for Metastatic Cancer Treatment

Advanced Science, Journal Year: 2019, Volume and Issue: 6(10)

Published: March 13, 2019

Combined phototherapy and immunotherapy demonstrates strong potential in the treatment of metastatic cancers. An upconversion nanoparticle (UCNP) based antigen-capturing nanoplatform is designed to synergize phototherapies immunotherapy. In particular, this constructed via self-assembly DSPE-PEG-maleimide indocyanine green (ICG) onto UCNPs, followed by loading photosensitizer rose bengal (RB). ICG significantly enhances RB-based photodynamic therapy efficiency UCNP/ICG/RB-mal upon activation a near-infrared (NIR) laser, simultaneously achieving selective photothermal therapy. Most importantly, tumor-derived protein antigens, arising from phototherapy-treated tumor cells, can be captured retained situ, due functionality maleimide, which further enhance antigen uptake presentation antigen-presenting cells. The synergized photothermal, photodynamic, immunological effects using light-activated induces tumor-specific immune response. experiments, intratumoral administration UCNP/ICG/RB-mal, noninvasive irradiation with an NIR destroys primary tumors inhibits untreated distant tumors, poorly immunogenic, highly 4T1 mammary model. With simultaneous use anti-CTLA-4, about 84% treated tumor-bearing mice achieve long-term survival 34% develop immunity. Overall, provides promising approach for

Language: Английский

---

Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(22), P. 5506 - 5526

Published: Jan. 1, 2019

Cancer immunotherapy by educating or stimulating patients' own immune systems to attack cancer cells has demonstrated promising therapeutic responses in the clinic. However, although number of approved immunotherapeutics is rapidly increasing, key challenges such as limited clinical response rate and significant autoimmunity-related adverse effects remain be resolved. Recently, it been discovered that a diverse range biomaterials-assisted local treatment methods including localized radiotherapy, chemotherapy phototherapy are able stimulate systems, often inducing immunogenic cell death (ICD). The triggered tumor-specific immunological after treatments, especially combination with checkpoint blockade (ICB) therapy, can achieve abscopal effect whole-body spreading metastatic cells, later on result memory inhibit tumor recurrence. Moreover, delivery immunomodulatory therapeutics biomaterials also an alternative strategy improve reduce side immunotherapy. In this review, we would like summarize latest advances, opportunities utilizing strategies for enhancing anticancer immunity, discuss further prospects field together how may possibly translated into use.

Language: Английский

---

Advanced bioactive nanomaterials for biomedical applications

Exploration, Journal Year: 2021, Volume and Issue: 1(3)

Published: Dec. 1, 2021

Bioactive materials are a kind of with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. came into spotlight in late 1960s when researchers found that such as bioglass could react surrounding bone tissue for regeneration. In following decades, advances nanotechnology brought new development opportunities to bioactive nanomaterials. nanomaterials not simple miniaturization macroscopic materials. They exhibit bioactivities due their nanoscale size effect, high specific surface area, precise nanostructure, significantly influence interactions systems. Nowadays, have represented an important exciting area research. Current future applications ensure academic clinical importance. This review summaries recent field nanomaterials, evaluate factors bioactivities. Then, range potential biomedical discussed. Furthermore, limitations, challenges, also

Language: Английский

---

Multifunctional phototheranostic nanomedicine for cancer imaging and treatment

Materials Today Bio, Journal Year: 2019, Volume and Issue: 5, P. 100035 - 100035

Published: Nov. 7, 2019

Cancer, as one of the most life-threatening diseases, shows a high fatality rate around world. When improving therapeutic efficacy conventional cancer treatments, researchers also conduct extensive studies into alternative approaches, which are safe, valid, and economical. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), tumor-ablative function-reserving oncologic interventions, showing strong potential in clinical treatment. During phototherapies, non-toxic phototherapeutic agents can be activated upon light irradiation to induce cell death without causing much damage normal tissues. Besides, with rapid development nanotechnology past decades, phototheranostic nanomedicine has attracted tremendous interests aiming continuously refine their performance. Herein, we reviewed recent progress for improved therapy. After brief introduction principles related PDT PTT, existing works on developing by mainly focusing categories applications, particularly phototherapy-synergized immunotherapy, comprehensively reviewed. More importantly, conclusion future challenges from our point view delivered last part this article.

Language: Английский

---