The role of macrophages in the resolution of inflammation

Journal of Clinical Investigation, Journal Year: 2019, Volume and Issue: 129(7), P. 2619 - 2628

Published: May 19, 2019

Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum their ontogeny, the local environment in which they reside, type injuries pathogen to exposed. In this Review, we discuss role macrophages restoration after injury, highlighting important questions about how respond modify microenvironment restore homeostasis.

Language: Английский

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Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: May 29, 2021

Abstract In this article, we will describe the properties of albumin and its biological functions, types sources that can be used to produce nanoparticles, methods producing therapeutic applications importance nanoparticles in production pharmaceutical formulations. view increasing use Abraxane approval for treatment several cancer during final stages clinical trials other cancers, evaluate it compare effectiveness with conventional non formulations chemotherapy Paclitaxel is paid. examine role animal proteins Nano medicine various benefits these biomolecules preparation drug delivery carriers characteristics plant protein cages their potentials diagnosis treatment. Finally, advantages disadvantages are mentioned, as well

Language: Английский

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Harnessing tumor-associated macrophages as aids for cancer immunotherapy

Molecular Cancer, Journal Year: 2019, Volume and Issue: 18(1)

Published: Dec. 1, 2019

Abstract Cancer immunotherapies that engage immune cells to fight against tumors are proving be powerful weapons in combating cancer and becoming increasingly utilized the clinics. However, for majority of patients with solid tumors, little or no progress has been seen, presumably due lack adequate approaches can reprogram local immunosuppressive tumor milieu thus reinvigorate antitumor immunity. Tumor-associated macrophages (TAMs), which abundantly infiltrate most could contribute progression by stimulating proliferation, angiogenesis, metastasis, providing a barrier Initial TAMs-targeting strategies have shown efficacy across therapeutic modalities types both preclinical clinical studies. TAMs-targeted roughly divided into those deplete TAMs modulate activities. We here reviewed mechanisms become compromise TAMs-focused also summarized.

Language: Английский

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Tailoring Materials for Modulation of Macrophage Fate

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(12)

Published: Feb. 9, 2021

Human immune system acts as a pivotal role in the tissue homeostasis and disease progression. Immunomodulatory biomaterials that can manipulate innate immunity adaptive hold great promise for broad range of prophylactic therapeutic purposes. This review is focused on design strategies principles immunomodulatory from standpoint materials science to regulate macrophage fate, such activation, polarization, adhesion, migration, proliferation, secretion. It offers comprehensive survey discussion tunability material designs regarding physical, chemical, biological, dynamic cues modulating response. The tailorable encompasses surface properties, topography, mechanics, composition, dynamics. representative immunoengineering applications selected herein demonstrate how macrophage-immunomodulating are being exploited cancer immunotherapy, infection regeneration, inflammation resolution, vaccination. A perspective future research directions immunoregulatory also provided.

Language: Английский

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Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR‐II Light

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(48), P. 17425 - 17432

Published: Sept. 25, 2019

Abstract Current cancer therapy is seriously challenged by tumor metastasis and recurrence. One promising solution to these problems build antitumor immunity. However, immunotherapeutic efficacy highly impeded the immunosuppressive state of tumors. Here a new strategy presented, catalytic immunotherapy based on artificial enzymes. Cu 2− x Te nanoparticles exhibit tunable enzyme‐mimicking activity (including glutathione oxidase peroxidase) under near‐infrared‐II (NIR‐II) light. The cascade reactions catalyzed enzyme gradually elevates intratumor oxidative stress induce immunogenic cell death. Meanwhile, continuously generated reverses microenvironment, boosts immune responses eradicate both primary distant metastatic Moreover, immunological memory effect successfully acquired after treatment with suppress relapse.

Language: Английский

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Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: Feb. 19, 2022

Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent trials have produced suboptimal outcomes, with durable responses seen only in small number of patients. The tumor microenvironment (TME) been shown to be responsible for immune escape and therapy failure. vital component the TME is tumor-associated macrophages (TAMs), which are usually associated poor prognosis drug resistance, including immunotherapies, promising targets immunotherapy. Recently, nanoparticles, because their unique physicochemical characteristics, crucial translational moieties tackling tumor-promoting TAMs that amplify sensitize tumors immunotherapies safe effective manner. In this review, we mainly described current potential nanomaterial-based therapeutic strategies target TAMs, restricting survival, inhibiting recruitment functionally repolarizing tumor-supportive antitumor type. understanding origin polarization role progression prognostic significance was also discussed review. We highlighted evolution chimeric antigen receptor (CAR)-macrophage cell therapy.

Language: Английский

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CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling

Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(4)

Published: April 16, 2020

Abstract Prostate cancer stem cells (PCSCs) play a critical role in prostate progression and metastasis, which remains an obstacle for successful treatment. Tumor-associated macrophages (TAMs) are the most abundant immune cell population within tumor microenvironment (TME). Systematic investigation of interaction network signaling between PCSCs TAMs may help searching target to suppress metastasis. Herein, we demonstrated that TAMs-secreted CCL5 could significantly promote migration, invasion, epithelial–mesenchymal transition (EMT) as well self-renewal vitro. QPCR screening validated STAT3 significant response gene following RNA-sequencing mechanistic explorations further revealed metastasis via activating β-catenin/STAT3 signaling. Notably, knockdown not only suppressed xenografts growth bone but also inhibited tumorigenicity vivo. Finally, clinical investigations bioinformatic analysis suggested high expression was correlated with Gleason grade, poor prognosis, increased activity patients. Taken together, TAMs/CCL5 This study provides novel rationale developing potential molecular elimination metastatic prevention.

Language: Английский

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Activating Macrophage‐Mediated Cancer Immunotherapy by Genetically Edited Nanoparticles

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(47)

Published: Oct. 21, 2020

Immunomodulation of macrophages against cancer has emerged as an encouraging therapeutic strategy. However, there exist two major challenges in effectively activating for antitumor immunotherapy. First, ligation signal regulatory protein alpha (SIRPα) on to CD47, a "don't eat me" cells, prevents macrophage phagocytosis cells. Second, colony stimulating factors, secreted by polarize tumor-associated (TAMs) tumorigenic M2 phenotype. Here, it is reported that genetically engineered cell-membrane-coated magnetic nanoparticles (gCM-MNs) can disable both mechanisms. The gCM shell overexpressing SIRPα variants with remarkable affinity efficiently blocks the CD47-SIRPα pathway while MN core promotes TAM repolarization, synergistically triggering potent immune responses. Moreover, protects MNs from clearance; and turn, delivers gCMs into tumor tissues under navigation, promoting their systemic circulation accumulation. In melanoma breast models, shown gCM-MNs significantly prolong overall mouse survival controlling local growth distant metastasis. combination cell-membrane-coating nanotechnology genetic editing technique offers safe robust strategy body's responses

Language: Английский

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Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

Advanced Drug Delivery Reviews, Journal Year: 2019, Volume and Issue: 165-166, P. 15 - 40

Published: Dec. 6, 2019

Language: Английский

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Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Aug. 21, 2019

With the development of nanotechnology, significant progress has been made in design and manufacture nanoparticles (NPs) for use clinical treatments. Meanwhile, recent increases our understanding central role macrophages context inflammation cancer have reinvigorated interest as a drug target. Macrophages serve an integral maintaining steady state immune system are involved processes inflammation. Thus, tailored needed to accurately target potential transform disease treatment. Herein, we firstly present brief background information NPs carriers including but not limited types nanomaterial, their biological properties advantages application. Then macrophage effector mechanisms NP-based strategies aiming at targeting by eliminating or re-educating summarized. Additionally, nano-carriers diagnosis also discussed. Finally, significance macrophage-targeting nanomedicine is highlighted, with goal facilitating future translation.

Language: Английский

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