Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Two-dimensional metal–organic framework nanosheets: synthesis and applications

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 47(16), P. 6267 - 6295

Published: Jan. 1, 2018

Two-dimensional (2D) metal-organic framework (MOF) nanosheets are attracting increasing research attention due to their unique properties originating from ultrathin thickness, large surface area and high surface-to-volume atom ratios. Many great advances have been made in the synthesis application of 2D MOF over past few years. In this review, we summarize recent by using top-down methods, e.g. sonication exfoliation, mechanical Li-intercalation exfoliation chemical bottom-up i.e. interfacial synthesis, three-layer surfactant-assisted modulated synthesis. addition, progress nanosheet-based nanocomposites is also briefly introduced. The potential applications gas separation, energy conversion storage, catalysis, sensors biomedicine discussed. Finally, give our personal insights into challenges opportunities for future composites.

Language: Английский

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Tailoring the photoluminescence of atomically precise nanoclusters

Chemical Society Reviews, Journal Year: 2019, Volume and Issue: 48(8), P. 2422 - 2457

Published: Jan. 1, 2019

Fluorescent nanoclusters are an emerging class of modular nanomaterials. This review highlights recent developments in tailoring the photo-luminescence nanoclusters.

Language: Английский

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Metal–Organic Frameworks for Biomedical Applications

Small, Journal Year: 2020, Volume and Issue: 16(10)

Published: Feb. 6, 2020

Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes functional organic ligands through bonds, have attracted extensive research interest during the past decades. Due to unique features diverse compositions, facile synthesis, easy surface functionalization, high areas, adjustable porosity, tunable biocompatibility, MOFs been widely used in hydrogen/methane storage, catalysis, biological imaging sensing, drug delivery, desalination, gas separation, magnetic electronic devices, nonlinear optics, water vapor capture, etc. Notably, with rapid development synthetic methods functionalization strategies, smart MOF-based nanocomposites advanced bio-related properties designed fabricated meet growing demands MOF materials for biomedical applications. This work outlines synthesis recent advances fields, including cargo (drugs, nucleic acids, proteins, dyes) delivery cancer therapy, bioimaging, antimicrobial, biosensing, biocatalysis. The prospects challenges field also discussed.

Language: Английский

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Electromagnetic microwave absorption theory and recent achievements in microwave absorbers

Carbon, Journal Year: 2020, Volume and Issue: 168, P. 606 - 623

Published: July 17, 2020

Language: Английский

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Metal–Organic Framework‐Based Stimuli‐Responsive Systems for Drug Delivery

Advanced Science, Journal Year: 2018, Volume and Issue: 6(1)

Published: Nov. 20, 2018

Abstract With the rapid development of nanotechnology, stimuli‐responsive nanomaterials have provided an alternative for designing controllable drug delivery systems due to their spatiotemporally properties. As a new type porous material, metal–organic frameworks (MOFs) been widely used in biomedical applications, especially systems, owing tunable pore size, high surface area and volume, easy modification. Here, recent progress MOF‐based is presented, including pH‐, magnetic‐, ion‐, temperature‐, pressure‐, light‐, humidity‐, redox‐, multiple anticancer drugs. The remaining challenges suggestions future directions rational design nanomedicines are also discussed.

Language: Английский

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Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

Nano-Micro Letters, Journal Year: 2020, Volume and Issue: 12(1)

Published: May 2, 2020

Abstract Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted much attention in recent years. MOFs are regarded as a promising class nanocarriers drug delivery owing to well-defined structure, ultrahigh surface area and porosity, tunable pore size, easy chemical functionalization. In this review, the unique properties their advantages were discussed first section. Then, state-of-the-art strategies functionalize with therapeutic agents summarized, including adsorption, encapsulation, covalent binding, functional molecules building blocks. third section, most biological intracellular drugs, proteins, nucleic acids, especially aptamers, presented. Finally, challenges prospects comprehensively provide context future development efficient systems.

Language: Английский

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Nanocatalysts and other nanomaterials for water remediation from organic pollutants

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 408, P. 213180 - 213180

Published: Jan. 24, 2020

Language: Английский

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Metal–Organic Framework-Based Enzyme Biocomposites

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(3), P. 1077 - 1129

Published: Jan. 13, 2021

Because of their efficiency, selectivity, and environmental sustainability, there are significant opportunities for enzymes in chemical synthesis biotechnology. However, as the three-dimensional active structure is predominantly maintained by weaker noncovalent interactions, thermal, pH, stressors can modify or eliminate activity. Metal–organic frameworks (MOFs), which extended porous network materials assembled a bottom-up building block approach from metal-based nodes organic linkers, be used to afford protection enzymes. The self-assembled structures MOFs encase an enzyme process called encapsulation when MOF synthesized presence biomolecule. Alternatively, infiltrated into mesoporous surface bound via covalent processes. Integration this way affords allows maintain activity challenge conditions (e.g., denaturing agents, elevated temperature, non-native solvents). In addition forming simple enzyme/MOF biocomposites, other introduced composites improve recovery facilitate advanced applications sensing fuel cell technology. This review canvasses encapsulation, pore infiltration, adsorption summarizes strategies form multicomponent composites. Also, given that biocomposites straddle chemistry enzymology, provides assessment characterization methodologies MOF-immobilized identifies some key parameters development field.

Language: Английский

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Two-Dimensional Metal–Organic Framework/Enzyme Hybrid Nanocatalyst as a Benign and Self-Activated Cascade Reagent for in Vivo Wound Healing

ACS Nano, Journal Year: 2019, Volume and Issue: 13(5), P. 5222 - 5230

Published: April 19, 2019

Metal–organic frameworks (MOFs)-based peroxidase mimics have been seldom applied in the biomedical field, especially vivo. One of main reasons is their optimum reactions occur strong acidic environments with a pH 3–4, severely limiting applications living systems where neutral usually required. Other types also suffer such fatal defect. Additionally, direct introduction relatively high concentrated and toxic reaction reagent H2O2 would induce undesired damage to normal tissues. Herein, MOF-based hybrid nanocatalyst as benign self-activated cascade has constructed. Owing better catalytic performance compared three-dimensional bulk MOF, an ultrathin two-dimensional (2D) MOF (2D Cu-TCPP(Fe)) nanosheet chosen model mimic physically adsorb glucose oxidase (GOx) for fabricating nanocatalyst. Nontoxic can be continuously converted into abundant gluconic acid by GOx, avoiding use minimizing harmful side effects. The generated decrease value from 7 dramatically activating peroxidase-like activity 2D Cu-TCPP(Fe) nanosheets. Meanwhile, produced used subsequent catalysis activated nanosheets, leading efficient generation extremely hydroxyl radial antibacterial capacity. In vitro vivo results illustrate designed possesses robust effect negligible biotoxicity.

Language: Английский

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