Soft Materials by Design: Unconventional Polymer Networks Give Extreme Properties

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(8), P. 4309 - 4372

Published: April 12, 2021

Hydrogels are polymer networks infiltrated with water. Many biological hydrogels in animal bodies such as muscles, heart valves, cartilages, and tendons possess extreme mechanical properties including being extremely tough, strong, resilient, adhesive, fatigue-resistant. These also critical for hydrogels' diverse applications ranging from drug delivery, tissue engineering, medical implants, wound dressings, contact lenses to sensors, actuators, electronic devices, optical batteries, water harvesters, soft robots. Whereas numerous have been developed over the last few decades, a set of general principles that can rationally guide design using different materials fabrication methods various remain central need field materials. This review is aimed at synergistically reporting: (i) achieve physical properties, (ii) implementation strategies unconventional networks, (iii) future directions orthogonal multiple combined mechanical, physical, chemical, properties. Because these based on generic they applicable other elastomers organogels. Overall, will not only provide comprehensive systematic guidelines rational materials, but provoke interdisciplinary discussions fundamental question: why does nature select constitute major parts bodies?

Language: Английский

---

A guide to the composition and functions of the extracellular matrix

FEBS Journal, Journal Year: 2021, Volume and Issue: 288(24), P. 6850 - 6912

Published: Feb. 21, 2021

Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that provides structural support for the cells and tissues. Accumulated knowledge clearly demonstrated over last decade ECM plays key regulatory roles since it orchestrates cell signaling, functions, properties morphology. Extracellularly secreted as well cell‐bound factors are among major members family. Proteins/glycoproteins, such collagens, elastin, laminins tenascins, proteoglycans glycosaminoglycans, hyaluronan, their receptors CD44 integrins, responsible adhesion, comprise well‐organized functional with significant in health disease. On other hand, enzymes metalloproteinases specific glycosidases including heparanase hyaluronidases contribute to remodeling affect human health. Several processes them proliferation survival, migration, differentiation, autophagy, angiogenesis, immunity regulation affected by certain components. Structural alterations have been also associated disease progression. This guide on composition functions gives broad overview matrisome, macromolecules, interaction networks within surface, summarizes main features tissue organization emphasizes importance constituents development progression advances molecular targeting design new therapeutic strategies.

Language: Английский

---

Collagen in Wound Healing

Bioengineering, Journal Year: 2021, Volume and Issue: 8(5), P. 63 - 63

Published: May 11, 2021

Normal wound healing progresses through inflammatory, proliferative and remodeling phases in response to tissue injury. Collagen, a key component of the extracellular matrix, plays critical roles regulation either its native, fibrillar conformation or as soluble components milieu. Impairments any these stall chronic, non-healing state that typically requires some form intervention guide process back completion. Key factors hostile environment chronic are persistent inflammation, increased destruction ECM caused by elevated metalloproteinases other enzymes improper activation mediators process. being central several processes, has been utilized an adjunct therapy promote healing. In this work significance collagen different biological processes relevant reviewed summary current literature on use collagen-based products care is provided.

Language: Английский

---

Hydrolyzed Collagen—Sources and Applications

Molecules, Journal Year: 2019, Volume and Issue: 24(22), P. 4031 - 4031

Published: Nov. 7, 2019

Hydrolyzed collagen (HC) is a group of peptides with low molecular weight (3–6 KDa) that can be obtained by enzymatic action in acid or alkaline media at specific incubation temperature. HC extracted from different sources such as bovine porcine. These have presented health limitations the last years. Recently research has shown good properties found skin, scale, and bones marine sources. Type source extraction are main factors affect properties, peptide chain, solubility, functional activity. widely used several industries including food, pharmaceutical, cosmetic, biomedical, leather industries. The present review presents types HC, extraction, their applications biomaterial.

Language: Английский

---

The extracellular matrix as a multitasking player in disease

FEBS Journal, Journal Year: 2019, Volume and Issue: 286(15), P. 2830 - 2869

Published: March 25, 2019

Extracellular matrices (ECMs) are highly specialized and dynamic three-dimensional (3D) scaffolds into which cells reside in tissues. ECM is composed of a variety fibrillar components, such as collagens, fibronectin, elastin, non-fibrillar molecules proteoglycans, hyaluronan, glycoproteins including matricellular proteins. These macromolecular components interconnected forming complex networks that actively communicate with through binding to cell surface receptors and/or matrix effectors. ECMs exert diverse roles, either providing tissues structural integrity mechanical properties essential for tissue functions or regulating phenotype maintain homeostasis. molecular composition structure vary among tissues, markedly modified during normal repair well the progression various diseases. Actually, abnormal remodeling occurring pathologic circumstances drives disease by cell-matrix interactions. The importance also highlighted mutations genes give rise genetic disorders clinical phenotypes. In this review, we present critical emerging issues related assembly multitasking roles diseases osteoarthritis, fibrosis, cancer, mechanisms underlying matrix-based discussed. Research focused on 3D will help discover matrix-related causative abnormalities novel diagnostic tools therapeutic targets.

Language: Английский

---

Natural composite dressings based on collagen, gelatin and plant bioactive compounds for wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2019, Volume and Issue: 138, P. 854 - 865

Published: July 25, 2019

Language: Английский

---

Collagen‐based biomaterials for biomedical applications

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2021, Volume and Issue: 109(12), P. 1986 - 1999

Published: May 24, 2021

Collagen is an insoluble fibrous protein that composes the extracellular matrix in animals. Although collagen has been used as a biomaterial since 1881, properties and complex structure of are still extensive study subjects worldwide. In this article, several topics importance for understanding research reviewed starting from its historical milestones, followed by description superfamily structures, with focus on type I collagen. Subsequently, some superior collagen-based biomaterials, such biocompatibility, biodegradability, mechanical properties, cell activities, pinpointed. These make applicable biomedicine, wound healing, tissue engineering, surface coating medical devices, skin supplementation. Moreover, antimicrobial strategies general host responses regarding presented. Finally, current status clinical application three-dimensional (3D) printing techniques fabrication scaffolds reconstruction human heart's constituents, capillary structures or even entire organ, discussed. Besides, overall outlook future unique provided.

Language: Английский

---

Collagen: quantification, biomechanics and role of minor subtypes in cartilage

Nature Reviews Materials, Journal Year: 2020, Volume and Issue: 5(10), P. 730 - 747

Published: July 20, 2020

Language: Английский

---

The fibrogenic niche in kidney fibrosis: components and mechanisms

Nature Reviews Nephrology, Journal Year: 2022, Volume and Issue: 18(9), P. 545 - 557

Published: July 4, 2022

Language: Английский

---

Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: March 19, 2021

Biomaterials have had an increasingly important role in recent decades, biomedical device design and the development of tissue engineering solutions for cell delivery, drug integration, replacement, more. There is increasing trend to use natural substrates, such as macromolecules native plants animals improve biocompatibility biodegradability delivered materials. At same time, these materials favourable mechanical properties often considered be biologically inert. More importantly, possess innate functions due their unique chemical composition structure, which increase bioactivity therapeutic potential a wide range applications. While much focus has been on integrating into devices via spectrum cross-linking mechanisms, little attention drawn residual that hampered during isolation, purification, production processes. Herein, we discuss methods initial material characterisation determine bioactivity, means processing including cross-linking, decellularisation, purification techniques finally, biological assessment retained final product. This review aims address considerations biomaterials from polymers, through optimisation preservation bioactive components maximise inherent potency substrate promote regeneration.

Language: Английский

---