Recent Progress in Ferroptosis Inducers for Cancer Therapy

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(51)

Published: Oct. 8, 2019

Abstract Ferroptosis is a newly discovered form of regulated cell death that the nexus between metabolism, redox biology, and human health. Emerging evidence shows potential triggering ferroptosis for cancer therapy, particularly eradicating aggressive malignancies are resistant to traditional therapies. Recently, there has been great deal effort design develop anticancer drugs based on induction. Recent advances ferroptosis‐inducing agents at intersection chemistry, materials science, biology presented. The basis summarized first highlight feasibility characteristics therapy. A literature review inducers (including small molecules nanomaterials) then presented delineate their design, action mechanisms, applications. Finally, some considerations research spotlighted, followed by discussion challenges future development directions this burgeoning field.

Language: Английский

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The Metabolic Underpinnings of Ferroptosis

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(6), P. 920 - 937

Published: Nov. 20, 2020

Language: Английский

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Biomedicine Meets Fenton Chemistry

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(4), P. 1981 - 2019

Published: Jan. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Language: Английский

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An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: April 8, 2020

Abstract The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H 2 O ) chemodynamic (CDT). Here, we report a H /O self-supplying nanoagent, (MSNs@CaO -ICG)@LA, which consists manganese silicate (MSN)-supported calcium (CaO indocyanine green (ICG) with further surface modification phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet emits heat to melt the LA. exposed CaO reacts water produce for hypoxia-relieved ICG-mediated PDT -supplying MSN-based CDT, acting an open source strategy ROS production. Additionally, MSNs-induced glutathione depletion protects from scavenging, termed reduce expenditure. This expenditure effective inhibiting tumor growth both vitro vivo, improves generation efficiency multi-level ROS-involved therapies.

Language: Английский

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Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 19, 2021

Abstract Polyphenols, the phenolic hydroxyl group‐containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol‐containing nanoparticles attracted extensive research attention due to their antioxidation property, anticancer activity, universal adherent affinity, thus great promise preparation, stabilization, modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, other biomedical applications. Additionally, metal−polyphenol networks, formed by coordination interactions between polyphenols metal ions, been used prepare an important class surface modification, drug disease treatments. By focusing different materials (e.g., inorganic materials, polymers, proteins, nucleic acids), a comprehensive review synthesis properties is provided. Moreover, remarkable versatility applications, including biodetection, multimodal protein gene bone repair, antibiosis, cancer theranostics also demonstrated. Finally, challenges faced future regarding discussed.

Language: Английский

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Platelet Membrane‐Camouflaged Magnetic Nanoparticles for Ferroptosis‐Enhanced Cancer Immunotherapy

Small, Journal Year: 2020, Volume and Issue: 16(22)

Published: April 27, 2020

Abstract Although cancer immunotherapy has emerged as a tremendously promising therapy method, it remains effective only for several cancers. Photoimmunotherapy (e.g., photodynamic/photothermal therapy) could synergistically enhance the immune response of immunotherapy. However, excessively generated immunogenicity will cause serious inflammatory syndrome. Herein, biomimetic magnetic nanoparticles, Fe 3 O 4 ‐SAS @ PLT, are reported novel approach to sensitize ferroptosis and generate mild immunogenicity, enhancing rate non‐inflamed tumors ‐SAS@PLT built from sulfasalazine (SAS)‐loaded mesoporous nanoparticles (Fe ) platelet (PLT) membrane camouflage triggered ferroptotic cell death via inhibiting glutamate‐cystine antiporter system X c − pathway. PLT‐mediated significantly improves efficacy programmed 1 checkpoint blockade achieves continuous tumor elimination in mouse model 4T1 metastatic tumors. Proteomics studies reveal that not induce tumor‐specific but also efficiently repolarize macrophages immunosuppressive M2 phenotype antitumor M1 phenotype. Therefore, concomitant with expected provide great potential clinical treatment metastasis.

Language: Английский

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Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

Nano Letters, Journal Year: 2019, Volume and Issue: 19(11), P. 7866 - 7876

Published: Oct. 9, 2019

Nanoscale photodynamic therapy (PDT) is an appealing antitumor modality for which apoptosis the major mechanism of toxicity induction. It was postulated that highly reactive singlet oxygen in PDT could deplete glutathione (GSH) and activate ferroptosis, extent to be further manipulated by a redox-responsive nanocarrier. To validate this, disulfide-bearing imidazole ligand coordinated with zinc form all-active metal organic framework (MOF) nanocarrier where photosensitizer (chlorin e6/Ce6) encapsulated. Regardless light irradiation, Ce6-loaded caused depletion intracellular GSH via disulfide–thiol exchange reaction murine mammary carcinoma cell line (4T1). The inactivation peroxide 4 (GPX4) enhancement cytotoxicity alleviated ferroptosis inhibitors. superior vivo efficacy corroborated 4T1 tumor-bearing mice model regarding tumor growth suppression animal survival rate. coadministration iron chelator weakened potency due inhibition, supported fact upsurge recovered GPX4 activity. current work highlights contribution ferroptotic machinery activatable, adaptable, MOF

Language: Английский

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Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy

ACS Nano, Journal Year: 2020, Volume and Issue: 14(3), P. 3414 - 3425

Published: March 10, 2020

Photodynamic therapy (PDT) combined with oxygenating strategies is widely employed in cancer treatment; however, oxygen-boosted PDT has failed to achieve an ideal effect due the complexity, heterogeneity, and irreversible hypoxic environment generated by tumor tissues. With emergence of Fe-dependent ferroptosis boasting reactive oxygen species (ROS) cytotoxicity as well, such a chemodynamic approach drawn extensive attention. In this study, hemoglobin (Hb) connected photosensitizer chlorin e6 (Ce6) construct 2-in-1 nanoplatform (SRF@Hb-Ce6) Sorafenib (SRF, promotor) loaded, combining potent ferroptosis. Benefiting from intrinsic presence Fe capable binding oxygen, concurrently furnishes for oxygen-dependent Furthermore, amphiphilic MMP2-responsive peptide incorporated into skeleton ensure drug-release specificity safety improvement. Correlative measurements demonstrate potentiation SRF@Hb-Ce6. More importantly, strengthens recruiting immune cells secrete IFN-γ, which can sensitize our findings. The therapeutic synergistic treatment SRF@Hb-Ce6 vitro vivo was proven significant, revealing promising prospects nanoplatform.

Language: Английский

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Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(26), P. 10633 - 10638

Published: March 24, 2020

Abstract This study reports the development of iron‐chelated semiconducting polycomplex nanoparticles (SPFeN) for photoacoustic (PA) imaging‐guided photothermal ferrotherapy cancer. The hybrid polymeric nanoagent comprises a ferroptosis initiator (Fe 3+ ) and an amphiphilic (SP C serving as both nanotransducer iron ion chelator. By virtue poly(ethylene glycol) (PEG) grafting its small size, SPFeN accumulates in tumor living mice after systemic administration, which can be monitored by PA imaging. In acidic microenvironment, generates hydroxyl radicals, leading to ferroptosis; meanwhile, under NIR laser irradiation, it localized heat not only accelerate Fenton reaction but also implement therapy. Such combined ferrotherapeutic effect leads minimized dosage compared previous studies effectively inhibits growth mice, is possible controls.

Language: Английский

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Metal Ion-Directed Functional Metal–Phenolic Materials

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(13), P. 11432 - 11473

Published: May 10, 2022

Metal ions are ubiquitous in nature and play significant roles assembling functional materials fields spanning chemistry, biology, science. Metal-phenolic assembled from phenolic components the presence of metal through formation metal-organic complexes. Alkali, alkali-earth, transition, noble as well metalloids interacting with building blocks have been widely exploited to generate diverse hybrid materials. Despite extensive studies on synthesis metal-phenolic materials, a comprehensive summary how guide assembly compounds is lacking. A fundamental understanding engineering will facilitate specific properties. In this review, we focus diversity function material emerging applications. Specifically, discuss range underlying interactions, including (i) cation-π, (ii) coordination, (iii) redox, (iv) dynamic covalent highlight wide properties resulting these interactions. Applications (e.g., biological, catalytic, environmental) perspectives also highlighted.

Language: Английский

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