Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

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Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: July 19, 2019

Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes the fused cells (FCs) derived from dendritic (DCs) as tumor vaccines. The fusion immunologically interrelated two types results strong expression whole antigen complexes immunological co-stimulatory molecules on (FMs), allowing nanoparticle-supported FM (NP@FM) to function like presenting (APCs) for T cell immunoactivation. Moreover, tumor-antigen bearing NP@FM can be bio-recognized by DCs induce DC-mediated combination these immunoactivation pathways offers powerful antitumor immunoresponse. Through mimicking both APCs this cytomembrane vaccine strategy develop various toward multiple provide chances accommodating diverse functions originating supporters.

Language: Английский

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Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4432 - 4483

Published: Jan. 1, 2021

Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties widespread industrial use. In recent decades, accessibility, versatile reactivity, relative biocompatibility catalysed phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which been a major benefactor this emergence, as largely demonstrated by polydopamine polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms synthetic strategies PEN state-of-the-art provide timely comprehensive summary. review, we will focus on principles involved summarize use toolkit particle engineering bottom-up synthesis nanohybrid materials. Specifically, discuss attractive forces between phenolics complementary structural motifs confined systems synthesize high-quality products with controllable size, shape, composition, well surface chemistry function. Additionally, phenolic's numerous biosensing, bioimaging, disease treatment be highlighted. This review aims guidelines new scientists field serve an up-to-date compilation what has achieved area, while offering expert perspectives PEN's translational research.

Language: Английский

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Ferroptosis Promotes Photodynamic Therapy: Supramolecular Photosensitizer-Inducer Nanodrug for Enhanced Cancer Treatment

Theranostics, Journal Year: 2019, Volume and Issue: 9(11), P. 3293 - 3307

Published: Jan. 1, 2019

The noninvasive nature of photodynamic therapy (PDT) enables the preservation organ function in cancer patients.However, PDT is impeded by hypoxia tumor microenvironment (TME) caused high intracellular oxygen (O 2 ) consumption and distorted blood vessels.Therefore, increasing generation TME would be a promising methodology for enhancing PDT.Herein, we proposed concept ferroptosis-promoted based on biochemical characteristics cellular ferroptosis, which improved efficacy significantly producing reactive species (ROS) supplying O sustainably through Fenton reaction.In contrast to traditional strategies that increase decomposition limited concentration hydrogen peroxide (H ), our could maintain H reaction.Methods: For its association with sensitivity solute carrier family 7 member 11 (SLC7A11) expression was characterized bioinformatics analysis immunohistochemistry oral tongue squamous cell carcinoma (OTSCC) specimens.Afterwards, photosensitizer chlorin e6 (Ce6) ferroptosis inducer erastin were self-assembled into novel supramolecular Ce6-erastin nanodrug bonding π-π stacking.Then, obtained extensively anti-tumor towards OTSCC evaluated both vitro vivo.Results: SLC7A11 found upregulated OTSCC, potential target ferroptosis-mediated treatment.Ce6-erastin nanoparticles exhibited low cytotoxicity normal tissues.More significantly, over-accumulated ROS, increased inhibited lead enhanced toxicity CAL-27 cells satisfactory antitumor effects xenograft tumour mouse model upon irradiation.Conclusion: Our promoted approach markedly enhances anticancer actions relieving promoting ROS production, thereby work provides new overcoming hypoxia-associated resistance treatment.

Language: Английский

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Cancer Cell Membrane-Coated Nanoparticles for Cancer Management

Cancers, Journal Year: 2019, Volume and Issue: 11(12), P. 1836 - 1836

Published: Nov. 21, 2019

Cancer is a global health problem in need of transformative treatment solutions for improved patient outcomes. Many conventional treatments prove ineffective and produce undesirable side effects because they are incapable targeting only cancer cells within tumors metastases post administration. There desperate targeted therapies that can maximize success minimize toxicity. Nanoparticles (NPs) with tunable physicochemical properties have potential to meet the high precision therapies. At forefront nanomedicine biomimetic nanotechnology, which hides NPs from immune system provides superior capabilities by cloaking cell-derived membranes. cell membranes expressing “markers self” “self-recognition molecules” be removed wrapped around variety NPs, providing homotypic circumventing challenge synthetically replicating natural surfaces. Compared unwrapped membrane-wrapped (CCNPs) provide reduced accumulation healthy tissues higher metastases. The unique biointerfacing CCNPs enable their use as nanovehicles enhanced drug delivery, localized phototherapy, intensified imaging, or more potent immunotherapy. This review summarizes state-of-the-art CCNP technology insight path forward clinical implementation.

Language: Английский

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Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4162 - 4174

Published: March 1, 2022

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, 2TPEVDPP, with different number rotors were prepared. Experimental results showed that compounds excellent PSs, corresponding 2TPEVDPP nanoparticles (NPs) most possessed highest PCE. The photophysical properties NPs are particularly suitable for in vivo fluorescence imaging-guided synergistic PDT/PTT therapy. helpful exploiting phototherapeutic reagents high efficacy PDT PTT.

Language: Английский

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Bacteria-Responsive Biomimetic Selenium Nanosystem for Multidrug-Resistant Bacterial Infection Detection and Inhibition

ACS Nano, Journal Year: 2019, Volume and Issue: 13(12), P. 13965 - 13984

Published: Nov. 15, 2019

Multidrug-resistant (MDR) bacterial infections are a severe threat to public health owing their high risk of fatality. Noticeably, the premature degradation and undeveloped imaging ability antibiotics still remain challenging. Herein, selenium nanosystem in response bacteria-infected microenvironment is proposed as an antibiotic substitute detect inhibit methicillin-resistant Staphylococcus aureus (MRSA) with combined strategy. Using natural red blood cell membrane (RBCM) bacteria-responsive gelatin nanoparticles (GNPs), Ru–Se@GNP-RBCM was constructed for effective delivery Ru-complex-modified (Ru–Se NPs). Taking advantage RBCM, immune system clearance reduced exotoxins were neutralized efficiently. GNPs could be degraded by gelatinase pathogen-infected areas situ; therefore, Ru–Se NPs released destroy bacteria cells. intense fluorescence capability accurately monitor infection treatment process. Moreover, excellent vivo elimination facilitated wound healing process confirmed two kinds MRSA-infected mice models. Overall, above advantages proved that prepared promising alternative combat ever-threatening multidrug-resistant bacteria.

Language: Английский

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Recent advances in photonanomedicines for enhanced cancer photodynamic therapy

Progress in Materials Science, Journal Year: 2020, Volume and Issue: 114, P. 100685 - 100685

Published: May 26, 2020

Language: Английский

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Artificially Reprogrammed Macrophages as Tumor‐Tropic Immunosuppression‐Resistant Biologics to Realize Therapeutics Production and Immune Activation

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(15)

Published: Feb. 25, 2019

To engineer patient-derived cells into therapy-purposed biologics is a promising solution to realize personalized treatments. Without using gene-editing technology, live cell-typed therapeutic engineered for tumor treatment by artificially reprogramming macrophages with hyaluronic acid-decorated superparamagnetic iron oxide nanoparticles (HIONs). This nanoparticle-assisted cell-reprogramming strategy demonstrates profound advantages, due the combined contributions from biological regulation of HIONs and intrinsic nature macrophages. Firstly, reprogrammed present substantial improvement in their innate capabilities, such as more effective targeting efficient generation bioactive components (e.g., reactive oxygen species, cytokines) suppress growth. Furthermore, this cell exhibits cytostatic/proapoptotic effects specific cancer cells. Secondly, enable resistant intratumoral immunosuppressive environment. Thirdly, are endowed strong ability prime situ protumoral M2 antitumor M1 phenotype paracrine-like manner. Consequently, synergistic tumor-inhibition effect achieved. study shows that engineering nanomaterial-reprogrammed may be preferable option commonly used approaches where nanomaterials administrated induce bioresponse certain vivo.

Language: Английский

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Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(39)

Published: Aug. 9, 2020

Abstract Surface modification of nanomaterials is essential for their biomedical applications owing to passive immune clearance and damage reticuloendothelial systems. Recently, a cell membrane‐coating technology has been proposed as an ideal approach modify its facile functionalized process good biocompatibility improving performances synthetic nanomaterials. Here, recent advances membrane‐coated are reviewed based on the main biological functions membrane in living cells. An overview introduced understand potential applications. Then, summarized, including physical barrier with selective permeability cellular communication via information transmission reception processes. Finally, perspectives challenges about discussed.

Language: Английский

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