Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(45)
Published: July 19, 2023
Organic
phototheranostics
simultaneously
having
fluorescence
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window,
and
photothermal
photodynamic
functions
possess
great
prospects
tumor
diagnosis
therapy.
However,
such
generally
suffer
from
low
brightness
poor
performance
due
to
severe
solvatochromism.
Herein,
an
organic
NIR-II
fluorophore
AS1,
which
possesses
inverted
dependence
of
quantum
yield
on
polarity,
is
reported
serve
as
potent
for
After
encapsulation
AS1
into
nanostructures,
obtained
(AS1R
)
exhibit
high
extinction
coefficients
(e.g.,
68200
L
mol-1
cm-1
at
808
nm),
emission
with
up
4.7%
beyond
1000
nm,
conversion
efficiency
≈65%,
1
O2
4.1%.
The
characterization
photophysical
properties
demonstrates
that
AS1R
superior
other
types
brightness,
effect,
same
mass
concentration.
excellent
phototheranostic
enables
clear
visualization
complete
elimination
tumors
using
a
single
injection
dose.
This
study
merits
polarity
high-performance
agents
imaging
phototherapy
tumors.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14347 - 14405
Published: July 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(5), P. 2699 - 2804
Published: Feb. 29, 2024
The
ability
to
gain
spatiotemporal
information,
and
in
some
cases
achieve
control,
the
context
of
drug
delivery
makes
theranostic
fluorescent
probes
an
attractive
intensely
investigated
research
topic.
This
interest
is
reflected
steep
rise
publications
on
topic
that
have
appeared
over
past
decade.
Theranostic
probes,
their
various
incarnations,
generally
comprise
a
fluorophore
linked
masked
drug,
which
released
as
result
certain
stimuli,
with
both
intrinsic
extrinsic
stimuli
being
reported.
release
then
signaled
by
emergence
signal.
Importantly,
use
appropriate
fluorophores
has
enabled
not
only
this
emerging
fluorescence
marker
for
but
also
provided
modalities
useful
photodynamic,
photothermal,
sonodynamic
therapeutic
applications.
In
review
we
highlight
recent
work
particular
focus
are
activated
tumor
microenvironments.
We
summarize
efforts
develop
other
applications,
such
neurodegenerative
diseases
antibacterials.
celebrates
diversity
designs
reported
date,
from
discrete
small-molecule
systems
nanomaterials.
Our
aim
provide
insights
into
potential
clinical
impact
still-emerging
direction.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
35(3)
Published: Oct. 27, 2022
Phototheranostics
with
second
near-infrared
(NIR-II)
imaging
and
photothermal
effect
have
become
a
burgeoning
biotechnology
for
tumor
diagnosis
precise
treatment.
As
important
parameters
of
phototheranostic
agents
(PTAs),
fluorescence
quantum
yield
(QY)
conversion
efficiency
(PCE)
are
usually
considered
as
pair
contradictions
that
is
difficult
to
be
simultaneously
enhanced.
Herein,
fluorination
strategy
designing
A-D-A
type
PTAs
synchronously
improved
QY
PCE
proposed.
Experimental
results
show
the
molar
extinction
coefficient
(ε),
NIR-II
QY,
all
fluorinated
nanoparticles
(NPs)
definitely
compared
chlorinated
counterparts.
Theoretical
calculation
demonstrate
can
maximize
electrostatic
potential
difference
by
virtue
high
electronegativity
fluorine,
which
may
increase
intra/intermolecular
D-A
interactions,
tighten
molecule
packing,
further
promote
ε,
ultimately
leading
enhanced
PCE.
In
these
PTA
NPs,
FY6-NPs
display
emission
extended
1400
nm
highest
(4.2%)
(80%).
These
features
make
perform
well
in
high-resolution
vasculature
imaging-guided
therapy
(PTT)
tumors.
This
study
develops
valuable
guideline
constructing
organic
performance.
Aggregate,
Journal Year:
2023,
Volume and Issue:
4(5)
Published: May 6, 2023
Abstract
Cancer
is
one
of
the
most
fatal
diseases
for
decades.
Aggregation‐induced
emission
luminogens
(AIEgens)
have
been
recently
used
as
molecular
imaging
or
therapeutic
agents
in
cancers,
due
to
advantages
large
Stokes
shift,
high
quantum
yield,
great
biocompatibility,
and
strong
photostability.
AIEgens
can
specifically
target
different
types
cancer
via
diverse
targeting
strategies.
AIEgen‐based
fluorescence
imaging,
especially
near‐infrared
demonstrated
deep
penetration
suitable
signal‐to‐noise
ratio,
which
allows
reliable
vivo
imaging.
Combined
with
other
modalities,
multimodal
could
provide
multidimensional
hallmarks
from
perspectives.
In
addition,
phototherapy
be
photodynamic
therapy
photothermal
therapy,
facilitate
ablation
cells
good
biosafety
effects
vivo.
nanoparticles
fabricated
some
specific
chemicals,
drugs,
siRNA,
display
synergistic
cancers.
This
paper
comprehensively
describes
current
status
future
perspectives
AIEgens,
showed
a
potential
preclinical
clinical
translation
on
theranostics
cancer.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(1)
Published: Aug. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(25)
Published: April 20, 2023
NIR-II-emitting
photosensitizers
(PSs)
have
attracted
great
research
interest
due
to
their
promising
clinical
applications
in
imaging-guided
photodynamic
therapy
(PDT).
However,
it
is
still
challenging
realize
highly
efficient
PDT
on
NIR-II
PSs.
In
this
work,
we
develop
a
chlorination-mediated
π-π
organizing
strategy
improve
the
of
PS
with
conjugation-extended
A-D-A
architecture.
The
significant
dipole
moment
carbon-chlorine
bond
and
strong
intermolecular
interactions
chlorine
atoms
bring
compact
stacking
chlorine-substituted
PS,
which
facilitates
energy/charge
transfer
promotes
photochemical
reactions
PDT.
Consequently,
resultant
emitting
exhibits
leading
performance
yield
reactive
oxygen
species
higher
than
that
previously
reported
long-wavelength
These
findings
will
enlighten
future
design
PSs
enhanced
efficiency.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 21, 2024
Abstract
Photodynamic
therapy
(PDT)
is
a
promising
cancer
treatment
but
has
limitations
due
to
its
dependence
on
oxygen
and
high-power-density
photoexcitation.
Here,
we
report
polymer-based
organic
photosensitizers
(PSs)
through
rational
PS
skeleton
design
precise
side-chain
engineering
generate
•O
2
−
•OH
under
oxygen-free
conditions
using
ultralow-power
808
nm
photoexcitation
for
tumor-specific
photodynamic
ablation.
The
designed
skeletons
can
electron-hole
pairs
sensitize
H
O
into
with
photoexcitation,
achieving
NIR-photoexcited
oxygen-independent
production.
Further,
compared
commonly
used
alkyl
side
chains,
glycol
oligomer
as
the
chain
mitigates
recombination
offers
more
molecules
around
generated
from
hydrophobic
skeletons,
which
yield
4-fold
stronger
production,
thus
allowing
an
high
PDT
effect.
Finally,
feasibility
of
developing
activatable
PSs
in
female
mice
further
demonstrated
irradiation
15
mW
cm
−2
.
study
not
only
provides
insights
mechanism
also
general
guideline
develop
NIR
PDT.
