ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(14), P. 10288 - 10301
Published: April 1, 2024
Insufficient
reactive
oxygen
species
(ROS)
production
and
radioresistance
have
consistently
contributed
to
the
failure
of
radiotherapy
(RT).
The
development
a
biomaterial
capable
activating
ROS-induced
apoptosis
ferroptosis
is
potential
strategy
enhance
RT
sensitivity.
To
achieve
precision
high-efficiency
RT,
theranostic
nanoplatform
Au/Cu
nanodots
(Au/CuNDs)
were
designed
for
dual-mode
imaging,
amplifying
ROS
generation,
inducing
apoptosis-ferroptosis
sensitize
RT.
A
large
amount
derived
from
three
aspects:
(1)
When
exposed
ionizing
radiation,
Au/CuNDs
effectively
absorb
photons
emit
various
electrons,
which
can
interact
with
water
produce
ROS.
(2)
act
as
catalase-like
abundant
through
Fenton
reaction
hydrogen
peroxide
overexpressed
tumor
cells.
(3)
deplete
glutathione,
causes
accumulation
Large
amounts
radiation
further
lead
by
increasing
DNA
damage,
enhancing
lipid
peroxidation,
significantly
improving
therapeutic
efficiency
Furthermore,
serve
an
excellent
nanoprobe
high-resolution
near-infrared
fluorescence
imaging
computed
tomography
tumors.
promising
performance
shows
their
application
in
clinical
cancer
detection
imaging-guided
minimizing
damage
adjacent
normal
tissues
during
In
summary,
our
developed
integrates
sensitizes
via
ROS-activated
apoptosis-ferroptosis,
offering
prospect
diagnosis
treatment.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
MedComm – Oncology,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: March 1, 2024
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(14), P. 10288 - 10301
Published: April 1, 2024
Insufficient
reactive
oxygen
species
(ROS)
production
and
radioresistance
have
consistently
contributed
to
the
failure
of
radiotherapy
(RT).
The
development
a
biomaterial
capable
activating
ROS-induced
apoptosis
ferroptosis
is
potential
strategy
enhance
RT
sensitivity.
To
achieve
precision
high-efficiency
RT,
theranostic
nanoplatform
Au/Cu
nanodots
(Au/CuNDs)
were
designed
for
dual-mode
imaging,
amplifying
ROS
generation,
inducing
apoptosis-ferroptosis
sensitize
RT.
A
large
amount
derived
from
three
aspects:
(1)
When
exposed
ionizing
radiation,
Au/CuNDs
effectively
absorb
photons
emit
various
electrons,
which
can
interact
with
water
produce
ROS.
(2)
act
as
catalase-like
abundant
through
Fenton
reaction
hydrogen
peroxide
overexpressed
tumor
cells.
(3)
deplete
glutathione,
causes
accumulation
Large
amounts
radiation
further
lead
by
increasing
DNA
damage,
enhancing
lipid
peroxidation,
significantly
improving
therapeutic
efficiency
Furthermore,
serve
an
excellent
nanoprobe
high-resolution
near-infrared
fluorescence
imaging
computed
tomography
tumors.
promising
performance
shows
their
application
in
clinical
cancer
detection
imaging-guided
minimizing
damage
adjacent
normal
tissues
during
In
summary,
our
developed
integrates
sensitizes
via
ROS-activated
apoptosis-ferroptosis,
offering
prospect
diagnosis
treatment.
