Ultrasound‐Controllable Release of Carbon Monoxide in Multifunctional Polymer Coating for Synergetic Treatment of Catheter‐Related Infections

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Medical catheters are susceptible to biological contamination and pathogen invasion, leading infection inflammatory complications. The development of antimicrobial coatings for medical devices has emerged as a promising strategy. However, limited functionality the incompatibility between bactericidal properties biosafety remain great challenges. Herein, multifunctional polymer coating (CPB-Ac) is created, incorporating an ultrasonic-responsive carbon monoxide release unit (CORM-Ac) antifouling treat catheter-related As-synthesized CPB-Ac can be stably anchored various with arbitrary shapes compositions via facile UV treatment. Both in vivo vitro experiments demonstrated that this multi-functional exhibits anti-fouling, anti-inflammatory, broad-spectrum antibacterial activities well good biosafety. During initial implantation phase, units effectively inhibit attachment contaminants, significantly reducing risk thrombosis bacterial infection. Once occurs, ultrasonic irradiation activate CO much higher amount 55.3 µm than non-ultrasound controls, therefore rapidly eliminating bacteria alleviating response. It believed work may provide effective method next-generation intelligent against

Language: Английский

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Synthesis and characterization methods of graphene oxide nanomaterial for biomedical and toxicity applications: A comprehensive review

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 113936 - 113936

Published: Jan. 1, 2025

Language: Английский

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Chemical Functionalization Meets Enhanced Electrical Conductivity in Iron Oxide Nanoparticles

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract An excellent combination of either oxides or metallic nanoparticles (NPs) and functional π‐electron rich conjugated molecules can originate a variety intriguing phenomena convenient for technological applications. Functional π‐conjugated aromatic hold the potential to control size, shape, morphology, optoelectronic properties through formation covalent interfaces. Interfacial charge transfer at nanoparticles−molecules interfaces plays vital roles in modulating photophysical electrical conductivity properties, which found enormous applications catalysis, electrical, magnetism. This work illustrates iron oxide (Fe 3 O 4 NPs) capped with situ generated aryl radicals tuning properties. Organic different groups are covalently attached surface Fe NPs radical formation. insulating pristine turns into semiconductor behavior upon functionalization, is due synergistic efficient intermolecular between mixed valence metal ions 2+ , d 6 electronic system, 3+ 5 system) (donor–acceptor interactions). A theoretical framework strongly supports experimental findings. These findings on using small molecule provide promising avenue wide range

Language: Английский

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Precision diagnosis of burn injuries using imaging and predictive modeling for clinical applications

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Burns represents a serious clinical problem because the diagnosis and assessment are very complex. This paper proposes methodology that combines use of advanced medical imaging with predictive modeling for improvement burn injury assessment. The proposed framework makes Adaptive Complex Independent Components Analysis (ACICA) Reference Region (TBSA) methods in conjunction deep learning techniques precise estimation depth Total Body Surface Area analysis. It also allows burns high accuracy, calculation TBSA, non-invasive analysis 96.7% accuracy using an RNN model. Extensive experimentation on DCE-LUV samples validates enhanced diagnostic precision detailed texture These technologies provide nuanced insights into severity, improving treatment planning. Our results demonstrate potential these to revolutionize care optimize patient outcomes.

Language: Английский

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Ultrasound-activated mechanochemical reactions for controllable biomedical applications

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Advanced Carriers for Precise Delivery and Therapeutic Mechanisms of Traditional Chinese Medicines: Integrating Spatial Multi‐Omics and Delivery Visualization

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract The complex composition of traditional Chinese medicines (TCMs) has posed challenges for in‐depth study and global application, despite their abundance bioactive compounds that make them valuable resources disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise This involves elucidating the structure‐activity relationships within compositions, ensuring accurate in vivo delivery, monitoring delivery process. review discusses research progress precision treatment from three perspectives: spatial multi‐omics technology therapeutic activity, carrier systems medical imaging visualizing aim establish a novel paradigm advances therapy TCMs.

Language: Английский

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Harnessing Ultrasonic Technologies to Treat Staphylococcus Aureus Skin Infections

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 512 - 512

Published: Jan. 23, 2025

The rise of antibiotic-resistant Staphylococcus aureus strains, particularly MRSA, complicates the management skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat S. aureus-driven infections prevent progression biofilm formation chronic wounds. Low- high-frequency ultrasound (LFU HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, promoting repair through cavitation microbubble activity. These approaches integrate frequencies with microbubbles therapeutics, such antibiotics affimers, minimize resistance improve healing. Tailoring bioeffects on structures localized delivery technologies, including microneedle patches piezoelectric systems, presents promising solutions for early intervention structure (SSSIs).

Language: Английский

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Recent advancements in layered double hydroxides as an electrode material for high-performance asymmetric supercapacitors

Journal of Solid State Electrochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

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Dual‐Defect Regulated G‐C₃N₄ for Piezoelectric Catalytic Tumor Therapy with Enhanced Efficacy

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Piezoelectric catalysis for tumor treatment is an emerging method generating reactive oxygen species (ROS). However, the development and optimization of piezoelectric catalytic nanomaterials remain major challenge. Herein, by regulating internal surface defects graphene phase carbon nitride (defect‐engineered g‐C 3 N 4 ), its piezoelectricity sonocatalytic performance enhanced, thus achieving efficient treatment. By reducing bulk defects, charges excited ultrasound (US) within defect‐engineered can migrate more rapidly to material surface, thereby enhancing their participation in redox reactions. Increasing not only introduce active sites on but also enhance asymmetry structure, resulting excellent properties. This nanosheet effectively generate ROS cells induce cell apoptosis under US stimulation. work introduces a expands potential application materials

Language: Английский

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Catalytic Hybrid Lipid Nanoparticles Potentiate Circle RNA-Based Cytokine Immunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Cytokine therapeutics in cancer immunotherapy are greatly limited by their short half-time, serious toxicity, and frequent administration, which can possibly be addressed ribonucleic acid (RNA) technology through the expression of targeting cytokines situ. However, intracellular translation RNA remains restricted due to generation excessive reactive oxygen species (ROS) overconsumption adenosine triphosphate (ATP) within transfected cells. Herein, hybrid lipid nanoparticles (Mn-LNPs) developed incorporating small-sized trimanganese tetraoxide conventional nanoparticles, showing ability generate oxygen, eliminate ROS, boost ATP, thus enhancing efficiency. This platform is employed encapsulate interleukin 12 (IL-12)-encoding circular (Mn-LNPs@RNAIL-12) for tumor immunotherapy, exhibiting unparalleled advantages proliferation cytotoxic T cells stimulation antitumor immunity. Moreover, efficacy Mn-LNPs@RNAIL-12 further strengthened synergizing with immune checkpoint blockade therapy achieve durable potent performances.

Language: Английский

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