The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review DOI Creative Commons
Ahmed Imran,

Aqsa Gulzar,

Muhammad Rehman Gulzar

et al.

Developmental medico-life-sciences, Journal Year: 2024, Volume and Issue: 1(10), P. 4 - 22

Published: Dec. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Language: Английский

Synthesis and characterization methods of graphene oxide nanomaterial for biomedical and toxicity applications: A comprehensive review DOI
L. Syam Sundar, Muhammad Waqar Ashraf

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 113936 - 113936

Published: Jan. 1, 2025

Language: Английский

Citations

2
Chemical Functionalization Meets Enhanced Electrical Conductivity in Iron Oxide Nanoparticles DOI Open Access
Neha Singh, Anurag Pritam, Jonas Fransson

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract An excellent combination of either oxides or metallic nanoparticles (NPs) and functional π‐electron rich conjugated molecules can originate a variety intriguing phenomena convenient for technological applications. Functional π‐conjugated aromatic hold the potential to control size, shape, morphology, optoelectronic properties through formation covalent interfaces. Interfacial charge transfer at nanoparticles−molecules interfaces plays vital roles in modulating photophysical electrical conductivity properties, which found enormous applications catalysis, electrical, magnetism. This work illustrates iron oxide (Fe 3 O 4 NPs) capped with situ generated aryl radicals tuning properties. Organic different groups are covalently attached surface Fe NPs radical formation. insulating pristine turns into semiconductor behavior upon functionalization, is due synergistic efficient intermolecular between mixed valence metal ions 2+ , d 6 electronic system, 3+ 5 system) (donor–acceptor interactions). A theoretical framework strongly supports experimental findings. These findings on using small molecule provide promising avenue wide range

Language: Английский

Citations

2
Ultrasound‐Controllable Release of Carbon Monoxide in Multifunctional Polymer Coating for Synergetic Treatment of Catheter‐Related Infections DOI Open Access

Ziqing Liang,

Rui Sun, Xu Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Medical catheters are susceptible to biological contamination and pathogen invasion, leading infection inflammatory complications. The development of antimicrobial coatings for medical devices has emerged as a promising strategy. However, limited functionality the incompatibility between bactericidal properties biosafety remain great challenges. Herein, multifunctional polymer coating (CPB-Ac) is created, incorporating an ultrasonic-responsive carbon monoxide release unit (CORM-Ac) antifouling treat catheter-related As-synthesized CPB-Ac can be stably anchored various with arbitrary shapes compositions via facile UV treatment. Both in vivo vitro experiments demonstrated that this multi-functional exhibits anti-fouling, anti-inflammatory, broad-spectrum antibacterial activities well good biosafety. During initial implantation phase, units effectively inhibit attachment contaminants, significantly reducing risk thrombosis bacterial infection. Once occurs, ultrasonic irradiation activate CO much higher amount 55.3 µm than non-ultrasound controls, therefore rapidly eliminating bacteria alleviating response. It believed work may provide effective method next-generation intelligent against

Language: Английский

Citations

0
Advanced Carriers for Precise Delivery and Therapeutic Mechanisms of Traditional Chinese Medicines: Integrating Spatial Multi‐Omics and Delivery Visualization DOI Open Access
Yusheng Zhang, Zhiguo Lü, Jing Guo

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract The complex composition of traditional Chinese medicines (TCMs) has posed challenges for in‐depth study and global application, despite their abundance bioactive compounds that make them valuable resources disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise This involves elucidating the structure‐activity relationships within compositions, ensuring accurate in vivo delivery, monitoring delivery process. review discusses research progress precision treatment from three perspectives: spatial multi‐omics technology therapeutic activity, carrier systems medical imaging visualizing aim establish a novel paradigm advances therapy TCMs.

Language: Английский

Citations

0
Magnetically driven wireless implantable interface polarization-enhanced triboelectric nanogenerator for promoting neural cell differentiation DOI
Pengfan Wu, Yang Liu,

Fayang Wang

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110703 - 110703

Published: Jan. 1, 2025

Language: Английский

Citations

0
Harnessing Ultrasonic Technologies to Treat Staphylococcus Aureus Skin Infections DOI Creative Commons
John Hulme

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 512 - 512

Published: Jan. 23, 2025

The rise of antibiotic-resistant Staphylococcus aureus strains, particularly MRSA, complicates the management skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat S. aureus-driven infections prevent progression biofilm formation chronic wounds. Low- high-frequency ultrasound (LFU HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, promoting repair through cavitation microbubble activity. These approaches integrate frequencies with microbubbles therapeutics, such antibiotics affimers, minimize resistance improve healing. Tailoring bioeffects on structures localized delivery technologies, including microneedle patches piezoelectric systems, presents promising solutions for early intervention structure (SSSIs).

Language: Английский

Citations

0
Recent advancements in layered double hydroxides as an electrode material for high-performance asymmetric supercapacitors DOI

Reetika Karwasra,

Poonam Siwatch,

Yamini Gupta

et al.

Journal of Solid State Electrochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

Citations

0
Emerging elastic micro-nano materials for diagnosis and treatment of thrombosis DOI Creative Commons
Chenxin Lu, Chunjian Li, Ning Gu

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Thrombus is a blood clot that forms in vessel at the point of flaking. Thrombosis closely associated with cardiovascular diseases caused by different sources and factors. However, current clinical methods thrombus diagnosis treatment still have problems targeting, permeability, stability, biosafety. Therefore, recent years, based on development micro/nano technology, researchers tried to develop some new strategies for thrombosis. Due unique structural characteristics, micro-nano materials physiological environments show excellent transport delivery properties such as better vivo circulation, longer life span, targeting ability, controllable cellular internalization. Especially, elasticity stiffness are inherent mechanical well-designed materials, which can make them adapted needs thrombosis treatment. Herein, this review first introduces thrombotic microenvironment characterize process. Then, fine-tune pathological occurrence thrombosis, role elastic summarized. The properties, preparation methods, biological fate these been discussed detail. Following, applications biomedical imaging, drug delivery, therapy highlighted. Last, shortcomings future design discussed. This will provide ideas use nanotechnology future.

Language: Английский

Citations

0
Dual‐Defect Regulated G‐C3N4 for Piezoelectric Catalytic Tumor Therapy with Enhanced Efficacy DOI Open Access
Zhuang Yang, Meng Yuan, Bin Liu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Piezoelectric catalysis for tumor treatment is an emerging method generating reactive oxygen species (ROS). However, the development and optimization of piezoelectric catalytic nanomaterials remain major challenge. Herein, by regulating internal surface defects graphene phase carbon nitride (defect‐engineered g‐C 3 N 4 ), its piezoelectricity sonocatalytic performance enhanced, thus achieving efficient treatment. By reducing bulk defects, charges excited ultrasound (US) within defect‐engineered can migrate more rapidly to material surface, thereby enhancing their participation in redox reactions. Increasing not only introduce active sites on but also enhance asymmetry structure, resulting excellent properties. This nanosheet effectively generate ROS cells induce cell apoptosis under US stimulation. work introduces a expands potential application materials

Language: Английский

Citations

0
Catalytic Hybrid Lipid Nanoparticles Potentiate Circle RNA-Based Cytokine Immunotherapy DOI

Yongcan Li,

John Kevin Gan,

Jiaqi Lei

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Cytokine therapeutics in cancer immunotherapy are greatly limited by their short half-time, serious toxicity, and frequent administration, which can possibly be addressed ribonucleic acid (RNA) technology through the expression of targeting cytokines situ. However, intracellular translation RNA remains restricted due to generation excessive reactive oxygen species (ROS) overconsumption adenosine triphosphate (ATP) within transfected cells. Herein, hybrid lipid nanoparticles (Mn-LNPs) developed incorporating small-sized trimanganese tetraoxide conventional nanoparticles, showing ability generate oxygen, eliminate ROS, boost ATP, thus enhancing efficiency. This platform is employed encapsulate interleukin 12 (IL-12)-encoding circular (Mn-LNPs@RNAIL-12) for tumor immunotherapy, exhibiting unparalleled advantages proliferation cytotoxic T cells stimulation antitumor immunity. Moreover, efficacy Mn-LNPs@RNAIL-12 further strengthened synergizing with immune checkpoint blockade therapy achieve durable potent performances.

Language: Английский

Citations

0